EN1

Gene Name		engrailed homeobox 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Anatomical Structure Morphogenesis Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Midbrain Development Hindbrain Development Midbrain-hindbrain Boundary Development Embryonic Forelimb Morphogenesis Multicellular Organism Growth Response To Cocaine Pigmentation Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Development
Pathways
Drugs
Diseases
GWAS		Multiple sclerosis ( 19010793)
Protein-protein Interactions		3 interactors: JUN PAX6 TLE1
Entrez ID		2019
HPRD ID		08835
Ensembl ID		ENSG00000163064
Uniprot IDs		Q05925
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Organ Morphogenesis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Pancreatic A Cell Development Forebrain-midbrain Boundary Formation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Somatic Motor Neuron Fate Commitment Cellular Response To Potassium Ion Starvation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Leading Edge Cell Differentiation Positive Regulation Of Glucagon Secretion Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Gene Expression Rhombomere Morphogenesis Regulation Of Epithelial Cell Proliferation Regulation Of Asymmetric Cell Division Regulation Of Transcription From RNA Polymerase II Promoter Involved In Spinal Cord Motor Neuron Fate Specification Positive Regulation Of Cell Fate Specification Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Ventral Spinal Cord Interneuron Specification Pancreatic A Cell Differentiation Somatic Motor Neuron Differentiation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Monocyte Differentiation Forebrain Anterior/posterior Pattern Specification Cerebral Cortex Regionalization Negative Regulation Of Phosphorylation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Forebrain Dorsal/ventral Pattern Formation Regulation Of Glucagon Secretion Transcription, DNA-templated Oligodendrocyte Cell Fate Specification Lacrimal Gland Development Iris Morphogenesis SMAD Protein Import Into Nucleus RNA Biosynthetic Process Anatomical Structure Morphogenesis Cornea Development In Camera-type Eye Rhombomere Development Positive Regulation By Host Of Viral Transcription Insulin Metabolic Process Gland Development Formation Of Anatomical Boundary Negative Regulation By Host Of Viral Transcription Response To Drug Protein Localization To Organelle
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