CLCA4 and SLC39A7

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CLCA4	SLC39A7
Name		chloride channel accessory 4	solute carrier family 39 member 7
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Apical Plasma Membrane	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane
	Molecular Function	Metalloendopeptidase Activity Intracellularly Calcium-gated Chloride Channel Activity Chloride Channel Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding	Zinc Ion Transmembrane Transporter Activity Protein Binding Metal Ion Transmembrane Transporter Activity
	Biological Process	Proteolysis Chloride Transport Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport	Monoatomic Ion Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Metal Ion Transport B Cell Differentiation Transmembrane Transport Zinc Ion Transmembrane Transport Skin Epidermis Development Regulation Of Ferroptosis
Pathways		Stimuli-sensing channels	Zinc influx into cells by the SLC39 gene family
GWAS		Fasting glucose ( 34074324 )	No GWAS studies recorded
Novel Interactors		None recorded	1 novel interactors: STARD3
Interacting Genes		23 interacting genes: AQP2 BDKRB2 ELOVL4 ERGIC3 FAM209A FCER1G FKBP7 GPR42 LMNA MCFD2 MGST3 PANX1 RETREG3 SCN3B SLC22A23 SLC35E2A SLC39A2 SLC39A7 SPN THAP4 TMEM154 TMEM179B TMEM51	29 interacting genes: AQP6 BIK CLCA4 CRCT1 ERCC6 GJA8 KCNF1 KRTAP1-3 KRTAP5-7 KRTAP9-2 LCE1A LCE1C LCE1F LCE2C LCE2D LCE4A LCE5A LELP1 RGS17 RSPO2 SHISAL1 SLC34A2 SMCP SPRY3 TMEM14B TNFRSF10D UNC93A WFDC12 YY1
Entrez ID		22802	7922
HPRD ID		16719	09028
Ensembl ID		ENSG00000016602	ENSG00000112473
Uniprot IDs		Q14CN2	A0A024RCX7 B4DZZ8 Q92504
PDB IDs		Not available	8GZE
GO Terms Enriched among Interactors		Membrane Transmembrane Transport Regulation Of Acute Inflammatory Response To Antigenic Stimulus Endoplasmic Reticulum Membrane Endoplasmic Reticulum Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Metal Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport	Keratinization Epidermis Development Tissue Development