CLCA4 and TMEM179B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLCA4	TMEM179B
Description		chloride channel accessory 4	transmembrane protein 179B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Apical Plasma Membrane	Nucleolus Plasma Membrane Membrane Nuclear Speck Secretory Granule Membrane Azurophil Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Metalloendopeptidase Activity Intracellularly Calcium-gated Chloride Channel Activity Chloride Channel Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding	Protein Binding
	Biological Process	Proteolysis Chloride Transport Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways		Stimuli-sensing channels	Neutrophil degranulation
Drugs
Diseases
GWAS		Fasting glucose ( 34074324)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		23 interacting genes: AQP2 BDKRB2 ELOVL4 ERGIC3 FAM209A FCER1G FKBP7 GPR42 LMNA MCFD2 MGST3 PANX1 RETREG3 SCN3B SLC22A23 SLC35E2A SLC39A2 SLC39A7 SPN THAP4 TMEM154 TMEM179B TMEM51	47 interacting genes: ADIPOQ BTN2A2 C1QL4 C2CD2L C3orf52 CCDC167 CCL3L3 CCL4 CCL4L2 CD68 CLCA4 CLCN7 CLDN1 CLDN6 CTXN3 CYB561 DERL3 ERGIC3 FAM163A FATE1 FCER1G FXYD3 GALNT15 GKN1 GPR151 GUCA2A IGFBP5 KRTAP12-2 KTN1 LRP10 LYG1 MARCHF2 MFSD6 PLN SERP2 SLC1A1 SLC22A1 SLC52A1 SLC61A1 STX8 TM4SF19 TMEM14A TMEM236 TMEM237 TMEM242 TMEM47 TRARG1
Entrez ID		22802	374395
HPRD ID		16719	14186
Ensembl ID		ENSG00000016602	ENSG00000185475
Uniprot IDs		Q14CN2	G3V185 Q7Z7N9
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Regulation Of Acute Inflammatory Response To Antigenic Stimulus Endoplasmic Reticulum Membrane Endoplasmic Reticulum Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Metal Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport	Membrane Inorganic Anion Transport
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