CLCA4 and MCFD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLCA4	MCFD2
Description		chloride channel accessory 4	multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Apical Plasma Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus ER To Golgi Transport Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Metalloendopeptidase Activity Intracellularly Calcium-gated Chloride Channel Activity Chloride Channel Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding	Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Proteolysis Chloride Transport Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport	Gene Expression Protein Transport Vesicle-mediated Transport
Pathways		Stimuli-sensing channels	COPII-mediated vesicle transport Cargo concentration in the ER Transport to the Golgi and subsequent modification
Drugs			Antihemophilic factor, human recombinant Lonoctocog alfa Moroctocog alfa
Diseases			Combined deficiency of factors V and VIII (F5F8D)
GWAS		Fasting glucose ( 34074324)	Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Mean reticulocyte volume ( 32888494) Response to statin therapy ( 20339536)
Interacting Genes		23 interacting genes: AQP2 BDKRB2 ELOVL4 ERGIC3 FAM209A FCER1G FKBP7 GPR42 LMNA MCFD2 MGST3 PANX1 RETREG3 SCN3B SLC22A23 SLC35E2A SLC39A2 SLC39A7 SPN THAP4 TMEM154 TMEM179B TMEM51	11 interacting genes: APP CLCA4 CMTM5 F8 IL1RL1 LMAN1 P2RY6 PNLIPRP1 SCD SLC35A1 SYS1
Entrez ID		22802	90411
HPRD ID		16719	09693
Ensembl ID		ENSG00000016602	ENSG00000180398
Uniprot IDs		Q14CN2	B4DF17 Q8NI22
PDB IDs			2VRG 3A4U 3LCP 3WHT 3WHU 3WNX 4YGB 4YGC 4YGD 4YGE 8JP4 8JP5 8JP6 8JP7 8JP8 8JP9 8JPG
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Regulation Of Acute Inflammatory Response To Antigenic Stimulus Endoplasmic Reticulum Membrane Endoplasmic Reticulum Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Metal Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport	Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway COPII-coated ER To Golgi Transport Vesicle G Protein-coupled UDP Receptor Activity Cellular Response To Pyrimidine Ribonucleotide Monounsaturated Fatty Acid Biosynthetic Process Interleukin-33 Binding CMP-N-acetylneuraminate Transmembrane Transporter Activity CMP-N-acetylneuraminate Transmembrane Transport Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Chemokine Production Regulation Of Chemokine Production Golgi Lumen Platelet Alpha Granule Lumen Regulation Of Type II Interferon Production Trans-Golgi Network Membrane Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Coagulation Blood Coagulation Hemostasis Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane G Protein-coupled UTP Receptor Activity G Protein-coupled ADP Receptor Activity Chloride Transport Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Fatty Acid Biosynthetic Process Palmitoyl-CoA 9-desaturase Activity Stearoyl-CoA 9-desaturase Activity Interleukin-33 Receptor Activity CMP-N-acetylneuraminate Metabolic Process CMP-N-acetylneuraminate Biosynthetic Process Intermediate-density Lipoprotein Particle
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