LRRC45 and MCC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LRRC45	MCC
Description		leucine rich repeat containing 45	MCC regulator of Wnt signaling pathway
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Ciliary Basal Body	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Lamellipodium Cell Projection
	Molecular Function	Protein Binding	Protein Binding Signaling Receptor Activity
	Biological Process		Signal Transduction Negative Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Establishment Of Protein Localization Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Neuroblastoma (pediatric) ( 32599975) Refractive error ( 32231278)	Adult body size ( 32376654) Brain cytoarchitecture ( 20308991) Cerebral amyloid angiopathy ( 25188341) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858) Nicotine dependence symptom count ( 25555482) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		10 interacting genes: ALAS1 CCDC89 KXD1 MCC MID2 SSX2 SSX2B SSX7 THAP11 ZDHHC17	77 interacting genes: ALDOB ANP32B APP BAAT C8orf33 C8orf48 CBX5 CBX8 CCDC112 CCDC146 CCDC180 CCDC185 CCDC187 CDC14B CDK8 CDKL3 CEP57L1 CEP95 CFAP58 CYLC2 DNAAF4 DYNC1I1 ELOA ERBIN ESRRG FAM161A FGF16 FRAT2 GTF2E2 HEMGN HSD17B3 KAT5 KEAP1 KIF3C KIFC3 LRRC45 MSANTD3 MTNR1A NANS NEK2 NFKBIB NOL12 PCCA PNKP POLL PRPF18 RASAL2 RCOR3 SEC61B SFRP4 SLTM SLU7 SYT17 SYT6 TCEA2 TCEANC TGFB1 THAP7 TRMO TRMT2A TSHZ2 TSTD2 TXLNA UTP14C ZBTB48 ZNF12 ZNF189 ZNF202 ZNF264 ZNF3 ZNF35 ZNF417 ZNF438 ZNF497 ZNF543 ZNF648 ZNF792
Entrez ID		201255	4163
HPRD ID		14476	01157
Ensembl ID		ENSG00000169683	ENSG00000171444
Uniprot IDs		Q96CN5	P23508
PDB IDs			6MTU 6MTV
Enriched GO Terms of Interacting Partners?			Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Centrosome
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