SIK3 and TRIP6

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SIK3	TRIP6
Gene Name		SIK family kinase 3	thyroid hormone receptor interactor 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Interleukin-1 Receptor Complex
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Interleukin-1 Receptor Binding Protein Binding Zinc Ion Binding Kinase Binding Poly(A) RNA Binding Thyroid Hormone Receptor Binding
	Biological Process	Endochondral Ossification Protein Phosphorylation Regulation Of Protein Localization Limb Morphogenesis Multicellular Organism Growth Cartilage Development Involved In Endochondral Bone Morphogenesis	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Cell Migration Focal Adhesion Assembly
Pathways
Drugs
Diseases
GWAS		Response to Vitamin E supplementation ( 22437554)	Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)
Protein-Protein Interactions		6 interactors: CRTC2 HDAC5 PRKACA TRAF1 TRIP6 YWHAZ	105 interactors: ABI2 ADAMTSL4 AQP1 ARNT2 ATN1 ATP5O ATXN1 BCAR1 BYSL CATSPER1 CBLC CCL5 CEP57L1 CNTF CREB5 CTAG2 DHX37 DMRT3 DTX2 EXOC3-AS1 FAM124B FAM154A FAM46C FASLG FHL3 FRS3 GDPD5 GFI1B GNAI2 GSE1 HLA-DPB1 HOXA1 HOXA9 HOXB9 HYKK ILF3 INCA1 KIAA1683 KIF1A KIR2DL4 KLK15 KRTAP26-1 LMO2 LOC149950 LPAR2 MAPKBP1 MEMO1 METTL17 MSRB3 MVP NCK2 NEDD9 NEU4 NUP210 ODF1 OIP5 OTUB2 PDGFRB PDLIM4 PIN1 POM121 POM121L4P PPP1R16A PRKAA1 PRKAA2 PTK2 PTPN13 PXN RAD23A RERE RFX3 RHOA RHOQ RNF213 RNF214 SCRIB SIK3 SLC15A3 SLC25A6 SMAD1 SON SRC STAC STK16 SVIL SYNGAP1 TAB1 TCAF1 TEKT4 THRB TLR2 TMSB4X TPM3 TPM4 TRAF3IP2 TRAPPC2L TRIM29 TTLL10 TXN2 TXNDC5 VCL WT1-AS XRCC6BP1 YPEL3 ZBP1
Entrez ID		23387	7205
HPRD ID		11121	04242
Ensembl ID		ENSG00000160584	ENSG00000087077
Uniprot IDs		A1A5A8 A1A5A9 H0Y494 J3KPC8 Q9Y2K2	F2ZC06 Q15654
PDB IDs			1X61 2DLO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Component Assembly Positive Regulation Of Intracellular Transport Histone H3-K9 Modification Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Blood Vessel Endothelial Cell Migration Gluconeogenesis Histone Modification Hexose Biosynthetic Process Regulation Of Intracellular Transport Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Cell Migration Regulation Of Endothelial Cell Migration Positive Regulation Of Nucleocytoplasmic Transport Chromatin Modification Regulation Of Cell Motility Gene Expression Regulation Of Osteoblast Differentiation Regulation Of Establishment Of Protein Localization Cell Activation Regulation Of Locomotion Regulation Of Cellular Component Movement Histone H3-K9 Acetylation Histone H3-T6 Phosphorylation Chromatin Organization Glucose Metabolic Process Regulation Of Epithelial Cell Migration Positive Regulation Of Transport Regulation Of Protein Binding Carbohydrate Biosynthetic Process Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Localization Intrinsic Apoptotic Signaling Pathway Golgi Reassembly Platelet Activation Regulation Of Ossification Cell Junction Assembly Glucose Homeostasis Hexose Metabolic Process Cell-cell Junction Organization Regulation Of Nucleocytoplasmic Transport Release Of Cytoplasmic Sequestered NF-kappaB Apoptotic Process Regulation Of Angiogenesis Programmed Cell Death Histamine Secretion By Mast Cell Chromosome Organization Regulation Of Cellular Localization Cell Death Death	Signal Complex Assembly Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Response To Organic Substance Regulation Of Signaling Actin Filament-based Process Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction ERBB Signaling Pathway Cell Communication Cellular Process Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Multicellular Organismal Development Regulation Of Apoptotic Process Response To Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Protein Phosphorylation Cellular Response To Stimulus Platelet Activation Response To Hormone Response To Stress Cellular Response To Growth Factor Stimulus Response To Wounding Regulation Of Protein Metabolic Process Regulation Of Cell Death Actin Cytoskeleton Organization Wound Healing Signaling Transforming Growth Factor Beta Receptor Signaling Pathway Organ Development Regulation Of Cell Motility Cell Motility Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process
Tagcloud ?		aicar ampk ampkbeta blunted brsk1 brsk2 c433s caax cys433 farnesylated farnesylation fertile imidazolecarboxamide knockin lkb1 lkb1c433s lkb1s431a mark4 mimetic myristoylation nuak nuak1 phenformin prenylated raises riboside s431a ser431 snf1	adaptors ap competition dimerization discrete domains enables enhances example exerts focal glucocorticoid gr interacts intriguing isoform lim med1 mediating mediator negatively orchestrating promoters recruitment tethering thought thrap3 transrepression
Tagcloud (Difference) ?		aicar ampk ampkbeta blunted brsk1 brsk2 c433s caax cys433 farnesylated farnesylation fertile imidazolecarboxamide knockin lkb1 lkb1c433s lkb1s431a mark4 mimetic myristoylation nuak nuak1 phenformin prenylated raises riboside s431a ser431 snf1	adaptors ap competition dimerization discrete domains enables enhances example exerts focal glucocorticoid gr interacts intriguing isoform lim med1 mediating mediator negatively orchestrating promoters recruitment tethering thought thrap3 transrepression
Tagcloud (Intersection) ?