MIRLET7B and P3H1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIRLET7B	P3H1
Description		microRNA let-7b	prolyl 3-hydroxylase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex Extracellular Exosome Extracellular Vesicle	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Extracellular Matrix Protein-containing Complex Extracellular Exosome
	Molecular Function	MRNA Base-pairing Post-transcriptional Repressor Activity	Iron Ion Binding Protein Binding Collagen Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Procollagen-proline 3-dioxygenase Activity L-ascorbic Acid Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Reactive Oxygen Species MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of ERK1 And ERK2 Cascade Antibacterial Innate Immune Response Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Macrophage Apoptotic Process	Protein Folding Negative Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Projection Development Protein Hydroxylation Collagen Fibril Organization Regulation Of Ossification Negative Regulation Of Cell Growth Collagen Metabolic Process Regulation Of Protein Secretion Protein Stabilization Bone Development Negative Regulation Of Post-translational Protein Modification
Pathways			Collagen biosynthesis and modifying enzymes
Drugs			Ascorbic acid Proline
Diseases			Osteogenesis imperfecta
GWAS
Interacting Genes		99 interacting genes: ADARB1 AGO2 AIMP1 AIMP2 APOBEC3B ATXN2L C1QBP CELF1 CPSF1 CPSF6 CPSF7 CRTAP DARS1 DDX1 DDX21 DDX23 DDX3X DDX3Y DHX36 DHX37 EIF2AK2 ELAVL1 EPRS1 ERAL1 ESRP1 FAM98A FIP1L1 FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 P3H1 PDCD11 PGAM5 PLOD1 PTBP1 PUF60 PUM2 PURA QARS1 RARS1 RBFOX2 RBM12B RBM14 RBM4 RBM4B RTCA RTCB SF3A1 SF3B1 SF3B2 SF3B3 SFPQ SPOUT1 SYMPK SYNCRIP TAF15 TENT2 TRA2A TRA2B TUT7 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346	13 interacting genes: CDC42 MIR1-2 MIR107 MIR141 MIR18B MIR19A MIR19B1 MIR9-3 MIR92A1 MIRLET7A2 MIRLET7B MIRLET7I SLC2A4
Entrez ID		406884	64175
HPRD ID			11227
Ensembl ID		ENSG00000284520	ENSG00000117385
Uniprot IDs			Q32P28
PDB IDs			8K0E 8K0F 8K0I 8K0M 8K17 8KC9
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process MRNA Binding Nucleobase-containing Compound Metabolic Process RNA Splicing Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Macromolecule Metabolic Process Post-transcriptional Regulation Of Gene Expression Nucleus Ribonucleoprotein Complex Nucleoplasm MiRNA Binding Cytoplasmic Stress Granule MRNA Splicing, Via Spliceosome Aminoacyl-tRNA Synthetase Multienzyme Complex RNA Splicing, Via Transesterification Reactions Regulation Of Translation Regulation Of MRNA Processing Catalytic Step 2 Spliceosome Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Catabolic Process Spliceosomal Complex Negative Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Regulation Of RNA Stability Regulation Of MRNA Stability RNA Stabilization Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Translation MRNA Stabilization Regulation Of Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Metabolic Process Nucleolus MRNA Cleavage And Polyadenylation Specificity Factor Complex Double-stranded RNA Binding Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Gene Expression	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Extracellular Vesicle MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Negative Regulation Of Metabolic Process Negative Regulation Of Extracellular Matrix Organization MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Regulation Of Gene Expression Negative Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Macromolecule Biosynthetic Process Regulation Of Sprouting Angiogenesis Negative Regulation Of Inflammatory Response Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Translation Regulation Of Extracellular Matrix Organization Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Extracellular Matrix Assembly Regulation Of Matrix Metallopeptidase Secretion Cellular Response To Bacterial Lipopeptide Response To Bacterial Lipoprotein Negative Regulation Of Fibroblast Migration Regulation Of Macromolecule Metabolic Process Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death MRNA Destabilization Negative Regulation Of Defense Response Extracellular Space RNA Destabilization Negative Regulation Of Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process Regulation Of Angiogenesis Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Cell Migration Regulation Of Vasculature Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?