CELA1 and SERPINA3

Number of citations: 0 (PubMedID 2456771)
Data Source: HPRD (in vitro)

		CELA1	SERPINA3
Name		chymotrypsin like elastase 1	serpin family A member 3
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Nucleus Extracellular Matrix Platelet Alpha Granule Lumen Secretory Granule Lumen Azurophil Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Proteolysis Inflammatory Response Post-embryonic Development Wnt Signaling Pathway Exocrine Pancreas Development Multicellular Organism Growth Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Tissue Remodeling Digestive System Development Elastin Catabolic Process Pancreas Morphogenesis	Acute-phase Response Inflammatory Response Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium Response To Cytokine
Pathways		None	Platelet degranulation Neutrophil degranulation
Drugs		N,N-dimethylformamide Cumidine Mdl 101,146 2-[5-Methanesulfonylamino-2-(4-Aminophenyl)-6-Oxo-1,6-Dihydro-1-Pyrimidinyl]-N-(3,3,3-Trifluoro-1-Isopropyl-2-Oxopropyl)Acetamide N-{4-[(Carboxymethyl)carbamoyl]benzoyl}-L-valyl-N-[(3S)-1,1,1-trifluoro-4-methyl-2-oxo-3-pentanyl]-L-prolinamide N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-alanyl-L-alaninamide N-[2-(1-Formyl-2-Methyl-Propyl)-1-(4-Piperidin-1-Yl-but-2-Enoyl)-Pyrrolidin-3-Yl]-Methanesulfonamide Freselestat (3R)-3-ethyl-N-[(4-methylphenyl)sulfonyl]-L-aspartic acid (TERT-BUTYLOXYCARBONYL)-ALANYL-AMINO ETHYL-FORMAMIDE (2-BROMOETHYL)(2-'FORMYL-4'-AMINOPHENYL) ACETATE [1-(3-CHLORO-2-FORMYL-PHENYLCARBAMOYL)-2-METHYL-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER METHYL(2-ACETOXY-2-(2-CARBOXY-4-AMINO-PHENYL))ACETATE (2R)-3-{[(BENZYLAMINO)CARBONYL]AMINO}-2-HYDROXYPROPANOIC ACID 3-[[(METHYLAMINO)SULFONYL]AMINO]-2-OXO-6-PHENYL-N-[3,3,3-TRIFLUORO-1-(1-METHYLETHYL)-2-OXOPHENYL]-1(2H)-PYRIDINE ACETAMIDE (2S,3S)-3-FORMYL-2-({[(4-METHYLPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID (2S,3S)-3-FORMYL-2-({[(4-NITROPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID	Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
GWAS		Neutrophil count ( 32888494 ) Obesity-related traits ( 23251661 )	Blood protein levels ( 30072576 ) Body mass index ( 23669352 ) Prostate-specific antigen levels ( 28139693 ) Serum total protein levels ( 29403010 )
Interacting Genes		6 interacting genes: A2M CSN2 LPA PI3 SERPINA1 SERPINA3	29 interacting genes: ABCC5 ADAMTS4 ADH1B APP CELA1 CFTR CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 HSP90AA1 KLK13 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 POLR1H SGCD
Entrez ID		1990	12
HPRD ID		00553	00120
Ensembl ID		ENSG00000139610	ENSG00000196136
Uniprot IDs		Q9UNI1	P01011
PDB IDs		Not available	1AS4 1QMN 2ACH 3CAA 3DLW 4CAA 6HGE 9C2T 9D7K
GO Terms Enriched among Interactors		Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Endopeptidase Inhibitor Activity Extracellular Region Platelet Alpha Granule Lumen Extracellular Space Extracellular Matrix Acute-phase Response Growth Factor Binding Acute Inflammatory Response Plasma Lipoprotein Particle Negative Regulation Of Complement Activation, Lectin Pathway Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Copulation Protease Binding Interleukin-8 Binding Blood Microparticle Positive Regulation Of Chromatin Organization Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Neuregulin Receptor Activity X Chromosome ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Histone Kinase Activity Tumor Necrosis Factor Binding Interleukin-1 Binding Protection From Non-homologous End Joining At Telomere Schwann Cell Differentiation Regulation Of Heterochromatin Formation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Peptidase Activity Extracellular Matrix Disassembly Secretory Granule Proteolysis Extracellular Region Endopeptidase Activity Hydrolase Activity Extracellular Matrix Organization Extracellular Structure Organization Extracellular Space Protein Metabolic Process Macromolecule Metabolic Process Extracellular Matrix Protein Maturation Protein Processing Amelogenesis Defense Response To Fungus ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Defense Response To Bacterium Response To Fungus Neutrophil-mediated Killing Of Bacterium Glial Cell Development Angiotensin Maturation Protein-containing Complex Localization Response To Yeast Platelet Alpha Granule Protein Catabolic Process Response To Bacterium Neutrophil Mediated Immunity Protein-folding Chaperone Binding Basolateral Plasma Membrane Amyloid-beta Complex Monoatomic Ion Homeostasis Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Monoatomic Cation Homeostasis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Biofilm Matrix Disassembly Killing By Host Of Symbiont Cells Glycoprotein Catabolic Process Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Positive Regulation Of MAP Kinase Activity Regulation Of Protein Serine/threonine Kinase Activity Myelin Sheath