CELA1 and SERPINA3

Number of citations of the paper that reports this interaction (PMID 2456771)
0

Data Source:
HPRD (in vitro)

		CELA1	SERPINA3
Gene Name		chymotrypsin-like elastase family, member 1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Extracellular Region Extracellular Space Intracellular Nucleus Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Metal Ion Binding	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Proteolysis Inflammatory Response Post-embryonic Development Wnt Signaling Pathway Exocrine Pancreas Development Multicellular Organism Growth Regulation Of Cell Proliferation Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Pancreas Morphogenesis	Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Body mass index ( 23669352)
Protein-Protein Interactions		6 interactors: A2M CSN2 LPA PI3 SERPINA1 SERPINA3	25 interactors: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 ZNRD1
Entrez ID		1990	12
HPRD ID		00553	00120
Ensembl ID		ENSG00000139610	ENSG00000196136
Uniprot IDs		Q9UNI1	G3V5I3 P01011
PDB IDs			1AS4 1QMN 2ACH 3CAA 3DLW 4CAA
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Acute-phase Response Platelet Degranulation Acute Inflammatory Response Response To Methanol Regulation Of Body Fluid Levels Secretion Negative Regulation Of Complement Activation, Lectin Pathway Response To Triglyceride Response To Chromate Platelet Activation Regulation Of Metabolic Process Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Serine-type Peptidase Activity Cullin Deneddylation Protein Deneddylation Exocytosis Vesicle-mediated Transport Blood Coagulation, Intrinsic Pathway Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Complement Activation Inflammatory Response Blood Coagulation Hemostasis Epithelial Structure Maintenance Copulation Secretion By Cell Response To Lead Ion Regulation Of Complement Activation Wound Healing Negative Regulation Of Innate Immune Response Cell Activation Response To Wounding Regulation Of Humoral Immune Response Mating	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Proteolysis Protein Metabolic Process Killing By Host Of Symbiont Cells Defense Response Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Inflammatory Response Metabolic Process Regulation Of Protein Metabolic Process Neutrophil Mediated Immunity Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Stress Killing Of Cells Of Other Organism Wound Healing Negative Regulation Of Growth Of Symbiont In Host Regulation Of Growth Defense Response To Fungus Central Nervous System Development Interaction With Symbiont Leukocyte Mediated Cytotoxicity Peptide Hormone Processing Response To Wounding Negative Regulation Of Cytokine Biosynthetic Process Response To Fungus Blood Coagulation Inflammatory Response Hemostasis Defense Response To Bacterium Negative Regulation Of Interleukin-12 Biosynthetic Process Interleukin-1 Beta Biosynthetic Process Neuromuscular Junction Development Response To Bacterium Regulation Of Angiogenesis Protein Processing Negative Regulation Of Growth Collagen Catabolic Process Facial Nucleus Development Leading Strand Elongation Factor XII Activation Synaptic Growth At Neuromuscular Junction Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Platelet Degranulation Regulation Of Body Fluid Levels Regulation Of Translation Acute Inflammatory Response
Tagcloud ?			add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment proteases question remodeling resultsthe submitted supported
Tagcloud (Difference) ?			add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment proteases question remodeling resultsthe submitted supported
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