CELA1 and PI3

Number of citations of the paper that reports this interaction (PMID 8794736)
23

Data Source:
HPRD (in vivo)

		CELA1	PI3
Gene Name		chymotrypsin-like elastase family, member 1	peptidase inhibitor 3, skin-derived
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Proteinaceous Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Metal Ion Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Proteolysis Inflammatory Response Post-embryonic Development Wnt Signaling Pathway Exocrine Pancreas Development Multicellular Organism Growth Regulation Of Cell Proliferation Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Pancreas Morphogenesis	Copulation Negative Regulation Of Endopeptidase Activity
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: A2M CSN2 LPA PI3 SERPINA1 SERPINA3	5 interactors: CELA1 CSTA EVPL KRT1 LOR
Entrez ID		1990	5266
HPRD ID		00553	15947
Ensembl ID		ENSG00000139610	ENSG00000124102
Uniprot IDs		Q9UNI1	P19957
PDB IDs			1FLE 2REL
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Acute-phase Response Platelet Degranulation Acute Inflammatory Response Response To Methanol Regulation Of Body Fluid Levels Secretion Negative Regulation Of Complement Activation, Lectin Pathway Response To Triglyceride Response To Chromate Platelet Activation Regulation Of Metabolic Process Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Serine-type Peptidase Activity Cullin Deneddylation Protein Deneddylation Exocytosis Vesicle-mediated Transport Blood Coagulation, Intrinsic Pathway Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Complement Activation Inflammatory Response Blood Coagulation Hemostasis Epithelial Structure Maintenance Copulation Secretion By Cell Response To Lead Ion Regulation Of Complement Activation Wound Healing Negative Regulation Of Innate Immune Response Cell Activation Response To Wounding Regulation Of Humoral Immune Response Mating	Skin Development Peptide Cross-linking Keratinocyte Differentiation Epidermal Cell Differentiation Epidermis Development Organ Development Keratinization Epithelial Cell Differentiation System Development Multicellular Organismal Development Anatomical Structure Development Developmental Process Protein Metabolic Process Epithelium Development Pancreas Morphogenesis Complement Activation, Lectin Pathway Exocrine Pancreas Development Tissue Development Establishment Of Skin Barrier Regulation Of Water Loss Via Skin Fibrinolysis
Tagcloud ?			antiapoptotic ark augmented ax1 axl cascades coincubation erk forebrain gas6 gn10 gnrh gt1 mek migrating olfactory pd98059 phosphoinositide postmigratory programmed protects rescued starved threonine tyro7 ufo windows withdrawal wortmannin
Tagcloud (Difference) ?			antiapoptotic ark augmented ax1 axl cascades coincubation erk forebrain gas6 gn10 gnrh gt1 mek migrating olfactory pd98059 phosphoinositide postmigratory programmed protects rescued starved threonine tyro7 ufo windows withdrawal wortmannin
Tagcloud (Intersection) ?