CELA1

Name	chymotrypsin like elastase 1
Structure	No pdb structure
Novel Interactors	2 novel interactors: CDK2 ERBB3
Interactors	6 interactors: A2M CSN2 LPA PI3 SERPINA1 SERPINA3
GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Proteolysis Inflammatory Response Post-embryonic Development Wnt Signaling Pathway Exocrine Pancreas Development Multicellular Organism Growth Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Tissue Remodeling Digestive System Development Elastin Catabolic Process Pancreas Morphogenesis
Drugs	N,N-dimethylformamide Cumidine Mdl 101,146 2-[5-Methanesulfonylamino-2-(4-Aminophenyl)-6-Oxo-1,6-Dihydro-1-Pyrimidinyl]-N-(3,3,3-Trifluoro-1-Isopropyl-2-Oxopropyl)Acetamide N-{4-[(Carboxymethyl)carbamoyl]benzoyl}-L-valyl-N-[(3S)-1,1,1-trifluoro-4-methyl-2-oxo-3-pentanyl]-L-prolinamide N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-alanyl-L-alaninamide N-[2-(1-Formyl-2-Methyl-Propyl)-1-(4-Piperidin-1-Yl-but-2-Enoyl)-Pyrrolidin-3-Yl]-Methanesulfonamide Freselestat (3R)-3-ethyl-N-[(4-methylphenyl)sulfonyl]-L-aspartic acid (TERT-BUTYLOXYCARBONYL)-ALANYL-AMINO ETHYL-FORMAMIDE (2-BROMOETHYL)(2-'FORMYL-4'-AMINOPHENYL) ACETATE [1-(3-CHLORO-2-FORMYL-PHENYLCARBAMOYL)-2-METHYL-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER METHYL(2-ACETOXY-2-(2-CARBOXY-4-AMINO-PHENYL))ACETATE (2R)-3-{[(BENZYLAMINO)CARBONYL]AMINO}-2-HYDROXYPROPANOIC ACID 3-[[(METHYLAMINO)SULFONYL]AMINO]-2-OXO-6-PHENYL-N-[3,3,3-TRIFLUORO-1-(1-METHYLETHYL)-2-OXOPHENYL]-1(2H)-PYRIDINE ACETAMIDE (2S,3S)-3-FORMYL-2-({[(4-METHYLPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID (2S,3S)-3-FORMYL-2-({[(4-NITROPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID
GWAS	Neutrophil count ( 32888494 ) Obesity-related traits ( 23251661 )
Entrez ID	1990
HPRD ID	00553
Ensembl ID	ENSG00000139610
Uniprot IDs	Q9UNI1
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Endopeptidase Inhibitor Activity Extracellular Region Platelet Alpha Granule Lumen Extracellular Space Extracellular Matrix Acute-phase Response Growth Factor Binding Acute Inflammatory Response Plasma Lipoprotein Particle Negative Regulation Of Complement Activation, Lectin Pathway Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Copulation Protease Binding Interleukin-8 Binding Blood Microparticle Positive Regulation Of Chromatin Organization Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Neuregulin Receptor Activity X Chromosome ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Histone Kinase Activity Tumor Necrosis Factor Binding Interleukin-1 Binding Protection From Non-homologous End Joining At Telomere Schwann Cell Differentiation Regulation Of Heterochromatin Formation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway