TYMP and ZMYND12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TYMP	ZMYND12
Description		thymidine phosphorylase	zinc finger MYND-type containing 12
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GO Annotations	Cellular Component	Cytosol	Cilium Motile Cilium Sperm Flagellum Cell Projection
	Molecular Function	1,4-alpha-oligoglucan Phosphorylase Activity Protein Binding Growth Factor Activity Thymidine Phosphorylase Activity Pyrimidine-nucleoside Phosphorylase Activity Transferase Activity Glycosyltransferase Activity Pentosyltransferase Activity Protein Homodimerization Activity	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Angiogenesis Pyrimidine Nucleobase Metabolic Process Pyrimidine Nucleoside Metabolic Process Chemotaxis Signal Transduction Cell Differentiation Regulation Of Myelination DTMP Catabolic Process Regulation Of Transmission Of Nerve Impulse Nucleobase-containing Small Molecule Metabolic Process Pyrimidine-containing Compound Metabolic Process Carbohydrate Derivative Metabolic Process Regulation Of Gastric Motility	Sperm Axoneme Assembly Flagellated Sperm Motility
Pathways		Pyrimidine salvage Pyrimidine catabolism
Drugs		Tipiracil
Diseases		Mitochondrial DNA depletion syndrome (MDS)
GWAS		Blood protein levels ( 30072576) Chronic lymphocytic leukemia ( 28165464) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 20139978 27863252 29403010 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Red blood cell count ( 27863252 32888494) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		4 interacting genes: ERBB2 LINC01554 MESD ZMYND12	80 interacting genes: ABI2 AIRIM ARHGAP8 ARMC8 ATOSB BMAL1 CCDC116 CCDC24 CHCHD2 CWF19L2 DMRT3 EVX2 FAM222B FAM50B FAM90A1 GPKOW GSTZ1 HAPLN2 HDAC4 HOXB5 HOXC9 HR HSF4 ILF2 INCA1 KANK2 LENG1 LMO2 LMO4 MAD2L2 MNS1 MOAP1 MSGN1 MSRB3 NAB2 NUDT22 ONECUT3 PATL1 PICK1 POM121 POU6F2 PPP1R18 PRKAA2 PRR35 PRR5-ARHGAP8 PRR5L PSMB8 QARS1 RIPPLY1 RUSC1 SAMD11 SAXO1 SAXO4 SCNM1 SDCBP SEC14L4 SH2D4A SHC3 SMARCD1 SMG9 SOHLH1 SPG21 STRA8 TEKT4 TEKT5 TEPSIN TFAP2D THOC1 THRSP TLE5 TSEN54 TSSK3 TTC29 TXN2 TYMP UNC5CL VEZF1 VPS37C ZNF148 ZNF414
Entrez ID		1890	84217
HPRD ID		08833	15740
Ensembl ID		ENSG00000025708	ENSG00000066185
Uniprot IDs		B2RBL3 E5KRG5 P19971	B4DX70 Q9H0C1
PDB IDs		1UOU 2J0F 2WK5 2WK6	8J07
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Immature T Cell Proliferation In Thymus RNA Polymerase I Core Binding Negative Regulation Of Immature T Cell Proliferation ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex ERBB2-ERBB3 Signaling Pathway Protein Localization To Cell Periphery ERBB3 Signaling Pathway Immature T Cell Proliferation In Thymus ERBB2-EGFR Signaling Pathway ERBB2-ERBB4 Signaling Pathway ERBB4 Signaling Pathway Protein Localization To Membrane Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of T Cell Differentiation In Thymus	Protein Binding Sperm Flagellum Axonemal A Tubule Inner Sheath Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Motile Cilium Regulation Of RNA Metabolic Process Nucleus Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Transcription Coregulator Activity
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