TYMP

Description		thymidine phosphorylase
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GO Annotations	Cellular Component	Cytosol
	Molecular Function	1,4-alpha-oligoglucan Phosphorylase Activity Protein Binding Growth Factor Activity Thymidine Phosphorylase Activity Pyrimidine-nucleoside Phosphorylase Activity Transferase Activity Glycosyltransferase Activity Pentosyltransferase Activity Protein Homodimerization Activity
	Biological Process	Angiogenesis Pyrimidine Nucleobase Metabolic Process Pyrimidine Nucleoside Metabolic Process Chemotaxis Signal Transduction Cell Differentiation Regulation Of Myelination DTMP Catabolic Process Regulation Of Transmission Of Nerve Impulse Nucleobase-containing Small Molecule Metabolic Process Pyrimidine-containing Compound Metabolic Process Carbohydrate Derivative Metabolic Process Regulation Of Gastric Motility
Pathways		Pyrimidine salvage Pyrimidine catabolism
Drugs		Tipiracil
Diseases		Mitochondrial DNA depletion syndrome (MDS)
GWAS		Blood protein levels ( 30072576) Chronic lymphocytic leukemia ( 28165464) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 20139978 27863252 29403010 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Red blood cell count ( 27863252 32888494) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		4 interacting genes: ERBB2 LINC01554 MESD ZMYND12
Entrez ID		1890
HPRD ID		08833
Ensembl ID		ENSG00000025708
Uniprot IDs		B2RBL3 E5KRG5 P19971
PDB IDs		1UOU 2J0F 2WK5 2WK6
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Immature T Cell Proliferation In Thymus RNA Polymerase I Core Binding Negative Regulation Of Immature T Cell Proliferation ErbB-3 Class Receptor Binding ERBB3:ERBB2 Complex ERBB2-ERBB3 Signaling Pathway Protein Localization To Cell Periphery ERBB3 Signaling Pathway Immature T Cell Proliferation In Thymus ERBB2-EGFR Signaling Pathway ERBB2-ERBB4 Signaling Pathway ERBB4 Signaling Pathway Protein Localization To Membrane Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of T Cell Differentiation In Thymus
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