E2F2 and HPCA

Data Source: HiPPIP (Novel)

		E2F2	HPCA
Name		E2F transcription factor 2	hippocalcin
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Rb-E2F Complex RNA Polymerase II Transcription Regulator Complex	Cytoplasm Cytosol Membrane Axon Dendrite Membrane Neuronal Cell Body Membrane Dendrite Cytoplasm Perikaryon Dendritic Spine Head Postsynapse Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Actin Binding Calcium Ion Binding Protein Binding Kinase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Sprouting Angiogenesis Lens Fiber Cell Apoptotic Process	Regulation Of Signal Transduction Calcium-mediated Signaling Inner Ear Development Retina Development In Camera-type Eye Cellular Response To Electrical Stimulus Cellular Response To Calcium Ion Positive Regulation Of Protein Targeting To Membrane Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Voltage-gated Calcium Channel Activity Response To Ketamine Response To L-glutamate Response To Aroclor 1254 Cellular Response To L-glutamate
Pathways		Oxidative Stress Induced Senescence Oncogene Induced Senescence Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	None
GWAS		Eosinophil count ( 27863252 32888494 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Lymphocyte count ( 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 32888494 27863252 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Neutrophil count ( 32888494 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 28957414 27863252 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Severe insulin-resistant type 2 diabetes ( 34737425 ) Sum eosinophil basophil counts ( 27863252 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) White blood cell count ( 32888494 27863252 )	Daytime nap ( 33568662 )
Novel Interactors		3 novel interactors: CD48 HPCA MUC1	12 novel interactors: APC BMP8B CSF3R DPYD E2F2 NDC80 NUDC RAE1 RUNX3 TMEM54 TNFRSF8 TUBA4A
Interacting Genes		20 interacting genes: ARID3A ATAD2 BCAR1 BRD2 CCNF CDK3 FHL2 GIT2 GNB5 GRB2 KMT5A RB1 RNF144A RYBP SP1 SPIB TFDP1 TFDP2 UCHL5 YY1	17 interacting genes: AP2B1 C1QTNF2 CKMT1A CKMT1B CREM DTX2 GATA5 IL36RN MLLT10 MYDGF NAIP NMT1 PRR35 SLC16A3 TEPSIN UQCRB VWC2
Entrez ID		1870	3208
HPRD ID		02692	00811
Ensembl ID		ENSG00000007968	ENSG00000121905
Uniprot IDs		Q14209	P84074
PDB IDs		1N4M	5G4P 5G58 5M6C 7OWM
GO Terms Enriched among Interactors		Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Chromatin Nucleoplasm Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Rb-E2F Complex Regulation Of Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Chromatin Organization G1/S Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Regulation Of Voltage-gated Calcium Channel Activity Ino80 Complex Positive Regulation Of Telomere Maintenance In Response To DNA Damage Cell Cycle G1/S Phase Transition Regulation Of DNA Strand Elongation Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Division Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Transcription Factor Binding Protein Localization To Chromosome DNA Damage Response PcG Protein Complex Transcription Coregulator Activity Positive Regulation Of Metabolic Process BHLH Transcription Factor Binding Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Chromosome Organization Cell Cycle Phase Transition Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle	Phosphocreatine Biosynthetic Process Creatine Kinase Activity