NDRG4 and NOL3

		NDRG4	NOL3
Description		NDRG family member 4	nucleolar protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Cell Projection Membrane	Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Membrane Sarcoplasm Sarcoplasmic Reticulum
	Molecular Function	Molecular_function Protein Binding	RNA Binding Signaling Receptor Binding Death Receptor Binding Calcium Ion Binding Protein Binding Death Effector Domain Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Caspase Binding
	Biological Process	Heart Looping Signal Transduction Visual Learning Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development Negative Regulation Of Smooth Muscle Cell Migration Cell Differentiation Embryonic Heart Tube Development Vesicle Docking Negative Regulation Of Smooth Muscle Cell Proliferation Cardiac Muscle Cell Proliferation Cell Migration Involved In Heart Development Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Endocytic Recycling	Response To Hypoxia Blood Vessel Remodeling Response To Ischemia MRNA Splice Site Recognition MRNA Processing Apoptotic Process RNA Splicing Negative Regulation Of Signal Transduction Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Striated Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Muscle Atrophy Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Injury Involved In Regulation Of Muscle Adaptation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Protein Complex Oligomerization Negative Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063) Liver enzyme levels (alanine transaminase) ( 33972514) Oily fish consumption ( 32066663) Pork consumption ( 32066663) QT interval ( 19305408 19305409 22726844) Schizophrenia ( 29483656)
Interacting Genes		37 interacting genes: AGTRAP APLNR ARFIP2 ARL6IP1 ATP5PF BCL2L13 CACFD1 CDR1 CIDEB CMTM5 COQ3 CPLX2 DERL3 DGAT2L6 ERGIC3 LEUTX LIME1 LRRC59 MAL2 MTIF3 PLP2 PRAF2 RABAC1 REEP6 RTN3 SCAMP1 SDR16C5 SFT2D2 SGK1 SIN3A SMPD2 SYNGR1 SYNGR3 SYP THAP4 TMEM208 YIF1A	17 interacting genes: BAX CASP2 CASP8 CSNK2A1 ETNK2 FADD NIF3L1 POT1 SIRPA SRSF9 TERF1 TERF2IP TFPT TINF2 TRAF6 UBQLN2 VASP
Entrez ID		65009	8996
HPRD ID		14817	05572
Ensembl ID		ENSG00000103034	ENSG00000140939
Uniprot IDs		A0A0S2Z5L7 A0A0S2Z5R7 B7Z9X4 Q9ULP0	O60936 Q5TZN6
PDB IDs			4UZ0
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Synaptic Vesicle Vesicle-mediated Transport Endoplasmic Reticulum Tubular Network Formation Cytoplasmic Vesicle Endoplasmic Reticulum Tubular Network Membrane Organization Synaptic Vesicle Membrane Regulation Of Synaptic Vesicle Priming Protein Binding Regulation Of Short-term Neuronal Synaptic Plasticity Endoplasmic Reticulum Organization Synaptic Vesicle Membrane Organization Endoplasmic Reticulum Membrane Organization	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Execution Phase Of Apoptosis Positive Regulation Of Telomere Maintenance Telomeric DNA Binding Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance G-rich Strand Telomeric DNA Binding Telomere Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Chromosome Organization Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Tumor Necrosis Factor Receptor Binding Regulation Of Chromosome Organization Positive Regulation Of Metabolic Process Death Effector Domain Binding Telomere Assembly Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cellular Component Organization Regulation Of Telomere Maintenance Via Telomerase Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Organelle Organization Regulation Of Cellular Response To Stress Ripoptosome CD95 Death-inducing Signaling Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Organelle Organization Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Death-inducing Signaling Complex Regulation Of Telomere Maintenance Via Telomere Lengthening Chromosome Organization Chromosome, Telomeric Region Positive Regulation Of Myeloid Leukocyte Differentiation TRAIL-activated Apoptotic Signaling Pathway Telomeric D-loop Disassembly Identical Protein Binding
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