DRP2 and UTRN

Number of citations: 0 (PubMedID 10767429)
Data Source: HPRD (in vitro)

		DRP2	UTRN
Name		dystrophin related protein 2	utrophin
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Postsynaptic Density Membrane Dendrite Cell Projection Perikaryon Synapse Glutamatergic Synapse	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cilium Dystrophin-associated Glycoprotein Complex Membrane Filopodium Filopodium Membrane Neuromuscular Junction Protein-containing Complex Ciliary Basal Body Sarcolemma Synapse Postsynaptic Membrane Extracellular Exosome Contractile Ring
	Molecular Function	Zinc Ion Binding Metal Ion Binding	Actin Binding Integrin Binding Protein Binding Zinc Ion Binding Vinculin Binding Protein Kinase Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Central Nervous System Development Synapse Organization Synaptic Signaling	Positive Regulation Of Cell-matrix Adhesion Muscle Contraction Muscle Organ Development Synaptic Signaling Regulation Of Sodium Ion Transmembrane Transport
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	EGR2 and SOX10-mediated initiation of Schwann cell myelination Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		None	Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
GWAS		No GWAS studies recorded	Age at first sexual intercourse ( 34211149 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) Loneliness (multivariate analysis) ( 27629369 ) Multisite chronic pain ( 31194737 33830993 ) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954 ) Refractive error ( 32231278 ) Remission after SSRI treatment in MDD or openness ( 29559929 ) Response to fenofibrate (triglyceride levels) ( 27002377 ) Response to mepolizumab in severe asthma ( 29229094 ) Response to SSRI in MDD or openness ( 29559929 ) Restless legs syndrome in migraine without aura ( 32918390 )
Interacting Genes		4 interacting genes: DAG1 DTNA PRX UTRN	20 interacting genes: ACTA1 ACTN2 C1QTNF9 CALM1 DAG1 DISC1 DMD DRP2 DTNA DTNB ITGB1BP1 MARCHF5 PCNT PGM5 PTEN PTPN12 SASH1 SNTA1 SNTB1 SNTB2
Entrez ID		1821	7402
HPRD ID		02083	00547
Ensembl ID		ENSG00000102385	ENSG00000152818
Uniprot IDs		Q13474	P46939 Q5T097 Q6LBS5
PDB IDs		Not available	1BHD 1QAG 6M5G
GO Terms Enriched among Interactors		Sarcolemma Contractile Ring Vinculin Binding Dystrophin-associated Glycoprotein Complex Synaptic Signaling Positive Regulation Of Cell-matrix Adhesion Cell-cell Signaling Filopodium Signaling Axon Ensheathment Muscle Attachment Cell Communication Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Calcium-dependent Cell-matrix Adhesion Synapse Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex Nerve Maturation Muscle Contraction Regulation Of Cell-substrate Adhesion Postsynaptic Membrane Dystroglycan Complex Response To Denervation Involved In Regulation Of Muscle Adaptation Trans-synaptic Signaling By Trans-synaptic Complex Laminin-1 Binding Schwann Cell Differentiation Photoreceptor Ribbon Synapse Muscle System Process Response To Muscle Inactivity Peripheral Nervous System Myelin Maintenance Trans-synaptic Signaling Dystroglycan Binding Protein-containing Complex Binding Response To Inactivity Branching Involved In Salivary Gland Morphogenesis Actin Binding Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Costamere Cellular Response To Sterol Positive Regulation Of Cell Adhesion Node Of Ranvier Laminin Binding Schwann Cell Development Nuclear Periphery Skeletal Muscle Tissue Regeneration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Commissural Neuron Axon Guidance Angiogenesis Involved In Wound Healing Axon Regeneration Morphogenesis Of An Epithelial Sheet	Dystrophin-associated Glycoprotein Complex Sarcolemma Cytoskeleton Synapse Focal Adhesion Costamere Filopodium Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Synaptic Signaling PDZ Domain Binding Muscle Contraction Actin Binding Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Syntrophin Complex Cell Projection Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cell Communication Muscle System Process Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Cell-matrix Adhesion Structural Constituent Of Muscle Regulation Of Monoatomic Ion Transmembrane Transport Channel Activator Activity Protein-containing Complex Cell-substrate Junction Sarcomere Regulation Of System Process Regulation Of Metal Ion Transport Positive Regulation Of Cell-matrix Adhesion Dystroglycan Binding Structural Molecule Activity Cell-cell Signaling Cytoplasm Vinculin Binding Nitric-oxide Synthase Binding Calmodulin Binding Signaling Regulation Of Heart Contraction Titin Binding Anchoring Junction Regulation Of Monoatomic Ion Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Regulation Of Cell-substrate Adhesion Cytoskeleton Organization Regulation Of Membrane Potential Nuclear Periphery Muscle Cell Development Plasma Membrane