DRP2 and DAG1

Number of citations: 0 (PubMedID 11430802)
Data Source: HPRD (two hybrid, in vivo)

		DRP2	DAG1
Name		dystrophin related protein 2	dystroglycan 1
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Postsynaptic Density Membrane Dendrite Cell Projection Perikaryon Synapse Glutamatergic Synapse	Golgi Membrane Extracellular Region Basement Membrane Extracellular Space Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Lumen Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Focal Adhesion External Side Of Plasma Membrane Cell Surface Dystrophin-associated Glycoprotein Complex Dystroglycan Complex Membrane Basolateral Plasma Membrane Lamellipodium Filopodium Extracellular Matrix Node Of Ranvier Nuclear Periphery Sarcolemma Costamere Plasma Membrane Raft Membrane Raft Synapse Postsynaptic Membrane Extracellular Exosome Contractile Ring Photoreceptor Ribbon Synapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse Postsynaptic Cytosol
	Molecular Function	Zinc Ion Binding Metal Ion Binding	Virus Receptor Activity Dystroglycan Binding Actin Binding Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Tubulin Binding Vinculin Binding SH2 Domain Binding Laminin Binding Laminin-1 Binding Protein-containing Complex Binding Alpha-actinin Binding
	Biological Process	Central Nervous System Development Synapse Organization Synaptic Signaling	Positive Regulation Of Cell-matrix Adhesion Morphogenesis Of An Epithelium Morphogenesis Of An Epithelial Sheet Heart Morphogenesis Membrane Protein Ectodomain Proteolysis Axon Guidance Heart Development Schwann Cell Differentiation Schwann Cell Development Response To Muscle Activity Response To Denervation Involved In Regulation Of Muscle Adaptation Protein Transport Muscle Attachment Calcium-dependent Cell-matrix Adhesion Nerve Development Nerve Maturation Myelination In Peripheral Nervous System Extracellular Matrix Organization Negative Regulation Of Cell Migration Axon Regeneration Positive Regulation Of Myelination Microtubule Anchoring Skeletal Muscle Tissue Regeneration Negative Regulation Of MAPK Cascade Response To Peptide Hormone Symbiont Entry Into Host Cell Regulation Of Synaptic Plasticity Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Synapse Organization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Involved In Wound Healing Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Cellular Response To Mechanical Stimulus Cellular Response To Cholesterol Commissural Neuron Axon Guidance Basement Membrane Organization Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 DAG1 core M2 glycosylations DAG1 core M3 glycosylations DAG1 core M1 glycosylations Regulation of expression of SLITs and ROBOs EGR2 and SOX10-mediated initiation of Schwann cell myelination Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Matriglycan biosynthesis on DAG1
Diseases		None	Limb-girdle muscular dystrophy (LGMD)
GWAS		No GWAS studies recorded	A body shape index ( 34021172 ) Body mass index ( 26426971 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Estimated glomerular filtration rate ( 31152163 ) Extremely high intelligence ( 29520040 ) Gut microbiota (functional units) ( 27694959 ) Inflammatory bowel disease ( 28067908 ) Intelligence (MTAG) ( 29326435 ) Mood instability ( 31168069 ) Pediatric autoimmune diseases ( 26301688 ) Plateletcrit ( 32888494 ) Refractive error ( 32231278 ) Regular attendance at a religious group ( 29970889 ) Resting heart rate ( 27798624 ) Sleep duration (short sleep) ( 30846698 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 28067908 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		4 interacting genes: DAG1 DTNA PRX UTRN	26 interacting genes: AGR2 AGR3 AGRN BGN CAV1 CAV3 DMD DRP2 FYN GRB2 HMGB1 ITGB1 LAMA1 LAMA2 LAMA5 MAGI1 MAP2 NCK1 RAPSN SHC1 SRC TLN1 TUBA1A UTRN WWP1 WWP2
Entrez ID		1821	1605
HPRD ID		02083	00546
Ensembl ID		ENSG00000102385	ENSG00000173402
Uniprot IDs		Q13474	Q14118
PDB IDs		Not available	1EG4 2MK7 5GGP 5LLK 6JJY 7E9K 7E9L
GO Terms Enriched among Interactors		Sarcolemma Contractile Ring Vinculin Binding Dystrophin-associated Glycoprotein Complex Synaptic Signaling Positive Regulation Of Cell-matrix Adhesion Cell-cell Signaling Filopodium Signaling Axon Ensheathment Muscle Attachment Cell Communication Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Calcium-dependent Cell-matrix Adhesion Synapse Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex Nerve Maturation Muscle Contraction Regulation Of Cell-substrate Adhesion Postsynaptic Membrane Dystroglycan Complex Response To Denervation Involved In Regulation Of Muscle Adaptation Trans-synaptic Signaling By Trans-synaptic Complex Laminin-1 Binding Schwann Cell Differentiation Photoreceptor Ribbon Synapse Muscle System Process Response To Muscle Inactivity Peripheral Nervous System Myelin Maintenance Trans-synaptic Signaling Dystroglycan Binding Protein-containing Complex Binding Response To Inactivity Branching Involved In Salivary Gland Morphogenesis Actin Binding Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Costamere Cellular Response To Sterol Positive Regulation Of Cell Adhesion Node Of Ranvier Laminin Binding Schwann Cell Development Nuclear Periphery Skeletal Muscle Tissue Regeneration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Commissural Neuron Axon Guidance Angiogenesis Involved In Wound Healing Axon Regeneration Morphogenesis Of An Epithelial Sheet	Dystroglycan Binding Neuromuscular Junction Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Ephrin Receptor Binding Sarcolemma Muscle Organ Development Muscle Structure Development Regulation Of Cellular Component Organization Integrin Binding Developmental Process Plasma Membrane Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Membrane Raft Nitric-oxide Synthase Binding T Cell Costimulation Regulation Of Metal Ion Transport Positive Regulation Of Cell-cell Adhesion Vinculin Binding Extracellular Matrix Structural Constituent Regulation Of Cell Migration Symbiont Entry Into Host Cell Regulation Of Multicellular Organismal Process Cytoskeleton Organization Regulation Of Cell Motility Dystrophin-associated Glycoprotein Complex Signaling Receptor Binding Transmembrane Transporter Binding Regulation Of Monoatomic Ion Transport Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Activation Regulation Of Monoatomic Cation Transmembrane Transport Negative Regulation Of Anoikis Cell Projection Organization Animal Organ Development Positive Regulation Of Leukocyte Cell-cell Adhesion Cell Adhesion Biological Process Involved In Interaction With Host Receptor Internalization Plasma Membrane Bounded Cell Projection Organization Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of MAPK Cascade Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Organelle Organization Regulation Of Anoikis