DPYD and HPCA

Data Source: HiPPIP (Novel)

		DPYD	HPCA
Name		dihydropyrimidine dehydrogenase	hippocalcin
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Cytosol Membrane Axon Dendrite Membrane Neuronal Cell Body Membrane Dendrite Cytoplasm Perikaryon Dendritic Spine Head Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Uracil Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Dihydropyrimidine Dehydrogenase (NADP+) Activity Protein Homodimerization Activity Metal Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Actin Binding Calcium Ion Binding Protein Binding Kinase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Purine Nucleobase Catabolic Process Pyrimidine Nucleobase Catabolic Process Thymine Catabolic Process Uracil Catabolic Process Thymidine Catabolic Process CMP Catabolic Process DCMP Catabolic Process Beta-alanine Biosynthetic Process UMP Catabolic Process DUMP Catabolic Process	Regulation Of Signal Transduction Calcium-mediated Signaling Inner Ear Development Retina Development In Camera-type Eye Cellular Response To Electrical Stimulus Cellular Response To Calcium Ion Positive Regulation Of Protein Targeting To Membrane Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Voltage-gated Calcium Channel Activity Response To Ketamine Response To L-glutamate Response To Aroclor 1254 Cellular Response To L-glutamate
Pathways		Pyrimidine catabolism	None
Drugs		(5S)-5-Iododihydro-2,4(1H,3H)-pyrimidinedione NADPH 6-Carboxymethyluracil Flavin adenine dinucleotide Flavin mononucleotide Uracil Eniluracil 5-Iodouracil Gimeracil Tegafur-uracil	None
Diseases		Dihydropyrimidine dehydrogenase deficiency	None
GWAS		Adult body size ( 32376654 ) Adverse response to drug ( 30420678 ) Anthropometric traits (multi-trait analysis) ( 30166351 ) Anxiety/tension (special factor of neuroticism) ( 30867560 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885 ) Body mass index ( 29273807 25673413 ) Borderline personality disorder ( 28632202 ) Chronotype ( 30696823 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Coronary artery disease ( 29212778 ) Daytime nap ( 33568662 ) Extremely high intelligence ( 29520040 ) Face memory ( 31596458 ) Feeling nervous ( 29500382 ) Gastroesophageal reflux disease ( 31527586 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Heel bone mineral density ( 30598549 ) Household income (MTAG) ( 31844048 ) Intelligence (MTAG) ( 29326435 ) Irritable mood ( 29500382 ) Menarche (age at onset) ( 25231870 ) Metabolite levels ( 23823483 ) Methadone dose in opioid dependence ( 28115739 ) Platelet count ( 21507922 ) Regular attendance at a pub or social club ( 29970889 ) Schizophrenia ( 30285260 29483656 25056061 23974872 22688191 ) Serum metabolite levels ( 33031748 ) Sleep duration ( 30531941 ) Sleep duration (short sleep) ( 30846698 ) Triglyceride levels ( 32154731 32203549 ) Waist-to-hip ratio adjusted for BMI ( 28552196 )	Daytime nap ( 33568662 )
Novel Interactors		8 novel interactors: CPB2 CSDE1 HPCA KCNJ4 OVGP1 RPS6KA3 SRC SULT2A1	12 novel interactors: APC BMP8B CSF3R DPYD E2F2 NDC80 NUDC RAE1 RUNX3 TMEM54 TNFRSF8 TUBA4A
Interacting Genes		3 interacting genes: CLK1 GOPC LXN	17 interacting genes: AP2B1 C1QTNF2 CKMT1A CKMT1B CREM DTX2 GATA5 IL36RN MLLT10 MYDGF NAIP NMT1 PRR35 SLC16A3 TEPSIN UQCRB VWC2
Entrez ID		1806	3208
HPRD ID		02036	00811
Ensembl ID		ENSG00000188641	ENSG00000121905
Uniprot IDs		Q12882	P84074
PDB IDs		Not available	5G4P 5G58 5M6C 7OWM
GO Terms Enriched among Interactors		None	Phosphocreatine Biosynthetic Process Creatine Kinase Activity