DNMT3A and RPS8

Number of citations of the paper that reports this interaction (PMID 15616584)
77

Data Source:
BioGRID (pull down)

		DNMT3A	RPS8
Gene Name		DNA (cytosine-5-)-methyltransferase 3 alpha	ribosomal protein S8
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Euchromatin XY Body Nucleus Nucleoplasm Nuclear Heterochromatin Cytoplasm Nuclear Matrix	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Cytosolic Small Ribosomal Subunit Ribonucleoprotein Complex Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Chromatin Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding DNA-methyltransferase Activity Identical Protein Binding Unmethylated CpG Binding Metal Ion Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates	Structural Constituent Of Ribosome Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Chromatin Organization Methylation-dependent Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Spermatogenesis DNA Methylation On Cytosine Within A CG Sequence Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Hypermethylation Of CpG Island Negative Regulation Of Gene Expression, Epigenetic S-adenosylhomocysteine Metabolic Process S-adenosylmethioninamine Metabolic Process Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process
Pathways		Chromatin modifying enzymes Chromatin organization Epigenetic regulation of gene expression PRC2 methylates histones and DNA RMTs methylate histone arginines DNA methylation	Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Crohn's disease ( 21102463) Height ( 18391951) Type 1 diabetes ( 21980299)
Protein-Protein Interactions		31 interactors: CBX1 DNMT1 DNMT3B DNMT3L EED EHMT1 EHMT2 EZH2 F8A1 HDAC1 HIST1H3A HIST1H3E MYC NRIP1 PIAS1 PRMT5 PTGES3 RB1 RPS8 SETDB1 SP100 SPI1 SUMO1 SUV39H1 TCL1A TERF2IP UBE2I UHRF1 USP7 ZBTB17 ZBTB18	4 interactors: CALM1 DNMT3A NDRG1 RPS4X
Entrez ID		1788	6202
HPRD ID		04141	15969
Ensembl ID		ENSG00000119772	ENSG00000142937
Uniprot IDs		Q9Y6K1	P62241 Q5JR94 Q5JR95
PDB IDs		2QRV 3A1A 3A1B 3LLR 3SVM	3J3A
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Chromosome Organization Chromatin Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic DNA Methylation On Cytosine Chromatin Modification DNA Methylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Nucleobase-containing Compound Metabolic Process Methylation DNA Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Organelle Organization Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Gene Expression DNA Metabolic Process Peptidyl-lysine Modification RNA Biosynthetic Process Histone Methylation Regulation Of Metabolic Process Transcription, DNA-templated Histone H3-K9 Modification Protein Methylation Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of Chromosome Organization Macromolecule Biosynthetic Process Histone H3-K9 Methylation Maintenance Of DNA Methylation Cellular Metabolic Process Histone Lysine Methylation Peptidyl-lysine Methylation Chromatin Silencing Peptidyl-amino Acid Modification	Membrane Organization S-adenosylmethioninamine Metabolic Process Hypermethylation Of CpG Island Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity DNA Methylation On Cytosine Within A CG Sequence Regulation Of High Voltage-gated Calcium Channel Activity C-5 Methylation Of Cytosine Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction S-adenosylhomocysteine Metabolic Process Positive Regulation Of Spindle Checkpoint Response To Metal Ion Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Methylation-dependent Chromatin Silencing DNA Methylation Involved In Embryo Development Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Cell Cycle Checkpoint Multicellular Organismal Development Detection Of Calcium Ion DNA Methylation On Cytosine Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Response To Inorganic Substance Regulation Of Cell Cycle Process Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Developmental Process Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Peripheral Nervous System Myelin Maintenance Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Regulation Of DNA Methylation Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity DNA Methylation Involved In Gamete Generation Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Spindle Checkpoint Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Cell Activation Regulation Of Gene Expression By Genetic Imprinting Nitric Oxide Metabolic Process Myelin Maintenance
Tagcloud ?		cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed	aquaticus eubacteria identities intergenic l14 l15 l18 l24 l30 l5 l6 maritima mesophile operon operons overlapped rpl14 rpl15 rps14 rps17 s10 s14 s17 spacer spc thermophile thermophilus thermotoga thermus
Tagcloud (Difference) ?		cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed	aquaticus eubacteria identities intergenic l14 l15 l18 l24 l30 l5 l6 maritima mesophile operon operons overlapped rpl14 rpl15 rps14 rps17 s10 s14 s17 spacer spc thermophile thermophilus thermotoga thermus
Tagcloud (Intersection) ?