DNA2 and RBBP8

Number of citations of the paper that reports this interaction (PubMedID 25909997)
38

Data Source:
BioGRID (affinity chromatography technology, pull down)

		DNA2	RBBP8
Description		DNA replication helicase/nuclease 2	RB binding protein 8, endonuclease
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Gamma DNA Polymerase Complex Mitochondrial Nucleoid	Nucleus Nucleoplasm Chromosome Transcription Repressor Complex Site Of Double-strand Break BRCA1-C Complex
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity RNA Binding Catalytic Activity Helicase Activity Nuclease Activity Endonuclease Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity 5'-flap Endonuclease Activity Single-stranded DNA Helicase Activity Deoxyribonuclease (pyrimidine Dimer) Activity 5'-3' DNA Helicase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding Damaged DNA Binding Transcription Corepressor Activity Nuclease Activity Endonuclease Activity Protein Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	DNA Replication Checkpoint Signaling Telomere Maintenance DNA Double-strand Break Processing DNA Replication Mitochondrial DNA Replication DNA Repair Base-excision Repair DNA Damage Response Telomere Maintenance Via Semi-conservative Replication DNA Geometric Change DNA Replication, Okazaki Fragment Processing DNA Replication, Removal Of RNA Primer Mitochondrial DNA Repair Positive Regulation Of DNA Replication Replication Fork Reversal T-circle Formation Mitotic Telomere Maintenance Via Semi-conservative Replication	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Blastocyst Hatching DNA Repair DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Homologous Recombination Mitotic G2/M Transition Checkpoint Negative Regulation Of DNA-templated Transcription Cell Division Meiotic Cell Cycle DNA Strand Resection Involved In Replication Fork Processing
Pathways		Removal of the Flap Intermediate from the C-strand HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation Removal of the Flap Intermediate G2/M DNA damage checkpoint Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2	HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Transcriptional Regulation by E2F6 Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs
Diseases			Seckel syndrome
GWAS		Hip circumference adjusted for BMI ( 34021172)	Eosinophil percentage of white cells ( 27863252) Estradiol levels ( 34255042) Height ( 18391951 25429064) Hip circumference adjusted for BMI ( 34021172) Intracranial aneurysm ( 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Late-onset myasthenia gravis ( 26562150) Lung function (FEV1) ( 30061609) Lymphocyte count ( 32888494) Scalp hair shape ( 26926045) Tuberculosis ( 20694014) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		3 interacting genes: BLM RBBP8 TRAF6	40 interacting genes: ATM BARD1 BRCA1 CLU CTBP1 CUL3 DNA2 FXR2 FZR1 HID1 IGFBP7 IKBKG IKZF1 IKZF3 KLHL15 LIMS1 LMO1 LMO2 LMO4 MAP2K4 NTAQ1 PAN2 PCNA PELI2 PIAS4 PIN1 PRRG4 RAF1 RB1 RBL1 RBL2 RGS17 RNF4 SIAH1 SIAH2 TGIF2 TMEM54 TOPBP1 UBE2I USP4
Entrez ID		1763	5932
HPRD ID		19123	04990
Ensembl ID		ENSG00000138346	ENSG00000101773
Uniprot IDs		P51530	Q99708
PDB IDs		5EAY	1Y98 2L4Z 4D2H 7BGF
Enriched GO Terms of Interacting Partners?		DNA Double-strand Break Processing Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Negative Regulation Of Cell Cycle G2/M Phase Transition DNA Damage Response Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Protein Serine/threonine Kinase Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Recombinational Repair Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Mitotic Cell Cycle Phase Transition Forked DNA-dependent Helicase Activity Regulation Of Protein Kinase Activity 8-hydroxy-2'-deoxyguanosine DNA Binding Double-strand Break Repair Telomeric G-quadruplex DNA Binding DNA/DNA Annealing Activity Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle DNA Recombination Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Kinase Activity RecQ Family Helicase-topoisomerase III Complex Telomeric D-loop Binding Y-form DNA Binding Negative Regulation Of Cell Cycle Process Cellular Response To Stress Cellular Response To Camptothecin Four-way Junction Helicase Activity BRCA1-C Complex Interleukin-17A-mediated Signaling Pathway Identical Protein Binding Regulation Of Mitotic Cell Cycle Phase Transition Intracellular Signal Transduction Negative Regulation Of Cell Cycle Telomere Maintenance Via Semi-conservative Replication DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Cellular Response To Hydroxyurea DNA Geometric Change Resolution Of DNA Recombination Intermediates Regulation Of Protein Phosphorylation Telomeric Loop Disassembly Regulation Of Phosphorylation Telomeric D-loop Disassembly Bubble DNA Binding G-quadruplex DNA Binding Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Nucleic Acid Metabolic Process Single-stranded DNA Endodeoxyribonuclease Activity CD40 Signaling Pathway	Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Mitotic Cell Cycle Post-translational Protein Modification Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Protein Modification Process BRCA1-B Complex Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Mitotic G2/M Transition Checkpoint Negative Regulation Of Biosynthetic Process Regulation Of Mitotic Cell Cycle Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Protein Ubiquitination Mitotic G2 DNA Damage Checkpoint Signaling Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Metabolic Process Homologous Recombination Nucleoplasm Regulation Of Apoptotic Signaling Pathway Protein Polyubiquitination DNA Strand Resection Involved In Replication Fork Processing
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