DNA2

Description		DNA replication helicase/nuclease 2
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Gamma DNA Polymerase Complex Mitochondrial Nucleoid
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity RNA Binding Catalytic Activity Helicase Activity Nuclease Activity Endonuclease Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity 5'-flap Endonuclease Activity Single-stranded DNA Helicase Activity Deoxyribonuclease (pyrimidine Dimer) Activity 5'-3' DNA Helicase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	DNA Replication Checkpoint Signaling Telomere Maintenance DNA Double-strand Break Processing DNA Replication Mitochondrial DNA Replication DNA Repair Base-excision Repair DNA Damage Response Telomere Maintenance Via Semi-conservative Replication DNA Geometric Change DNA Replication, Okazaki Fragment Processing DNA Replication, Removal Of RNA Primer Mitochondrial DNA Repair Positive Regulation Of DNA Replication Replication Fork Reversal T-circle Formation Mitotic Telomere Maintenance Via Semi-conservative Replication
Pathways		Removal of the Flap Intermediate from the C-strand HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation Removal of the Flap Intermediate G2/M DNA damage checkpoint Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		3 interacting genes: BLM RBBP8 TRAF6
Entrez ID		1763
HPRD ID		19123
Ensembl ID		ENSG00000138346
Uniprot IDs		P51530
PDB IDs		5EAY
Enriched GO Terms of Interacting Partners?		DNA Double-strand Break Processing Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Negative Regulation Of Cell Cycle G2/M Phase Transition DNA Damage Response Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Protein Serine/threonine Kinase Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Recombinational Repair Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Mitotic Cell Cycle Phase Transition Forked DNA-dependent Helicase Activity Regulation Of Protein Kinase Activity 8-hydroxy-2'-deoxyguanosine DNA Binding Double-strand Break Repair Telomeric G-quadruplex DNA Binding DNA/DNA Annealing Activity Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle DNA Recombination Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Kinase Activity RecQ Family Helicase-topoisomerase III Complex Telomeric D-loop Binding Y-form DNA Binding Negative Regulation Of Cell Cycle Process Cellular Response To Stress Cellular Response To Camptothecin Four-way Junction Helicase Activity BRCA1-C Complex Interleukin-17A-mediated Signaling Pathway Identical Protein Binding Regulation Of Mitotic Cell Cycle Phase Transition Intracellular Signal Transduction Negative Regulation Of Cell Cycle Telomere Maintenance Via Semi-conservative Replication DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Cellular Response To Hydroxyurea DNA Geometric Change Resolution Of DNA Recombination Intermediates Regulation Of Protein Phosphorylation Telomeric Loop Disassembly Regulation Of Phosphorylation Telomeric D-loop Disassembly Bubble DNA Binding G-quadruplex DNA Binding Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Nucleic Acid Metabolic Process Single-stranded DNA Endodeoxyribonuclease Activity CD40 Signaling Pathway
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