FAM9A and SETD8

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		FAM9A	SETD8
Gene Name		family with sequence similarity 9, member A	SET domain containing (lysine methyltransferase) 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus	Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	Protein Binding	P53 Binding Transcription Corepressor Activity Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity
	Biological Process		Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Transcription, DNA-templated Mitotic Nuclear Division Peptidyl-lysine Monomethylation Histone Lysine Methylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription, DNA-templated Cell Division
Pathways			Mitotic Prophase Condensation of Prophase Chromosomes Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: JMJD6 KDM1A PRMT1 SETD8 ZDHHC17	9 interactors: DTL E2F2 FAM9A HIST4H4 LEF1 PCNA TP53 TWIST1 UBE2I
Entrez ID		171482	387893
HPRD ID		06506	06254
Ensembl ID		ENSG00000183304	ENSG00000183955
Uniprot IDs		Q8IZU1	E3VVS3 Q9NQR1
PDB IDs			1ZKK 2BQZ 3F9W 3F9X 3F9Y 3F9Z 4IJ8
Enriched GO Terms of Interacting Partners?		Histone Modification Chromatin Modification Chromatin Organization Regulation Of Megakaryocyte Differentiation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Hematopoietic Progenitor Cell Differentiation Chromosome Organization Histone Demethylation Protein Demethylation Regulation Of Signal Transduction By P53 Class Mediator Cellular Protein Modification Process Demethylation Histone H3-R2 Demethylation Histone H4-R3 Demethylation Regulation Of Primitive Erythrocyte Differentiation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Cellular Protein Metabolic Process Histone Methylation Regulation Of Response To DNA Damage Stimulus Protein Methylation Regulation Of Myeloid Cell Differentiation Peptidyl-amino Acid Modification Protein Metabolic Process Negative Regulation Of Megakaryocyte Differentiation Myeloid Cell Differentiation Peptidyl-lysine Modification Peptidyl-lysine Monomethylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Organelle Organization Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Recognition Of Apoptotic Cell Histone H3-K4 Demethylation Leukocyte Differentiation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Megakaryocyte Differentiation Cellular Macromolecule Biosynthetic Process Positive Regulation Of Hormone Biosynthetic Process Macromolecule Biosynthetic Process Peptidyl-arginine N-methylation Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Histone H4-R3 Methylation Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Granulocyte Differentiation Phagocytosis, Recognition Regulation Of Intracellular Signal Transduction Histone Arginine Methylation	Cell Cycle Mitotic Cell Cycle Translesion Synthesis DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Postreplication Repair Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction By P53 Class Mediator Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Gene Expression Negative Regulation Of Striated Muscle Tissue Development Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Neural Crest Cell Migration Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Muscle Organ Development Positive Regulation Of Stem Cell Differentiation Regulation Of Cell Cycle Regulation Of Epithelial To Mesenchymal Transition Base-excision Repair Chromosome Organization T Cell Activation Involved In Immune Response Neural Crest Cell Development Cell Cycle Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Epithelium Development Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Telomere Maintenance Neural Crest Cell Differentiation Somitogenesis Positive Regulation Of Deoxyribonuclease Activity Cell Proliferation Involved In Heart Valve Development Positive Regulation Of Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Positive Regulation Of SUMO Transferase Activity
Tagcloud ?		aberrantly aberration ap1s2 brcc3 cpxcr1 cxorf45 ddx53 dmd fhl1 gabre gjb1 hdac8 hypermethylated hypomethylated hypomethylation hysterectomy irreversible leiomyoma leiomyomas myometrium nxf5 paired pcdh11x ream taf1 tag uterine vbp1 xist	5a battery biophysical catalyzes competitive comprehensive discovery extensively h4 h4k20 interesting kmt5a lysine methyltransferase methyltransferases monomethylates monomethylation pcna potencies proliferating pursued quinazoline sar scaffold set7 set8 substituents trends unc0379
Tagcloud (Difference) ?		aberrantly aberration ap1s2 brcc3 cpxcr1 cxorf45 ddx53 dmd fhl1 gabre gjb1 hdac8 hypermethylated hypomethylated hypomethylation hysterectomy irreversible leiomyoma leiomyomas myometrium nxf5 paired pcdh11x ream taf1 tag uterine vbp1 xist	5a battery biophysical catalyzes competitive comprehensive discovery extensively h4 h4k20 interesting kmt5a lysine methyltransferase methyltransferases monomethylates monomethylation pcna potencies proliferating pursued quinazoline sar scaffold set7 set8 substituents trends unc0379
Tagcloud (Intersection) ?