ASXL1 and HIST1H1C

Number of citations of the paper that reports this interaction (PMID 18258596)
25

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		ASXL1	HIST1H1C
Gene Name		additional sex combs like transcriptional regulator 1	histone cluster 1, H1c
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin PR-DUB Complex Extracellular Vesicular Exosome	Nucleosome Nucleus Nuclear Euchromatin
	Molecular Function	DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding	Protein Binding Chromatin DNA Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Response To Retinoic Acid Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Monoubiquitinated Histone H2A Deubiquitination Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Bone Development	Nucleosome Assembly Nucleosome Positioning
Pathways			DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Cellular Senescence Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: APP HIST1H1C SRPK1 STAT3	29 interactors: AEBP2 ASXL1 CDC73 CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 IL7R IRAK4 KPNA7 KPNB1 LEO1 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 RBM39 RBX1 VHL WDR12 WDR5 YBX1
Entrez ID		171023	3006
HPRD ID		16516	07514
Ensembl ID		ENSG00000171456	ENSG00000187837
Uniprot IDs		Q498B9 Q8IXJ9	P16403
PDB IDs
Enriched GO Terms of Interacting Partners?		Feeding Behavior Regulation Of Multicellular Organism Growth Sexual Reproduction Synaptic Growth At Neuromuscular Junction Reproduction DNA Packaging Intracellular Receptor Signaling Pathway Collateral Sprouting In Absence Of Injury Reproductive Process Defense Response Collateral Sprouting Axon Midline Choice Point Recognition DNA Conformation Change Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Nucleosome Positioning Axon Choice Point Recognition Negative Regulation Of Cell Development Negative Regulation Of Glycolytic Process Neuron Remodeling Sperm Chromatin Condensation Radial Glial Cell Differentiation Cell Development Phosphorylation MRNA Processing Interleukin-6-mediated Signaling Pathway MRNA Metabolic Process Cellular Copper Ion Homeostasis Viral Process RNA Processing JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Viral Genome Replication Behavior Copper Ion Homeostasis Suckling Behavior Regulation Of Growth Growth Hormone Receptor Signaling Pathway Temperature Homeostasis Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cellular Response To Growth Hormone Stimulus Cellular Response To Interleukin-6 Regulation Of Glycolytic Process Positive Regulation Of Notch Signaling Pathway Eating Behavior Spermatid Nucleus Differentiation Neuron Maturation Negative Regulation Of Neuron Migration MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity	Endodermal Cell Fate Commitment Protein Monoubiquitination Histone Monoubiquitination Positive Regulation Of Gene Expression Chromosome Organization Chromatin Modification Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Histone H2B Ubiquitination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Fate Commitment Involved In Formation Of Primary Germ Layer Regulation Of Nitrogen Compound Metabolic Process Chromatin Organization Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Endodermal Cell Differentiation Stem Cell Maintenance Histone Modification Negative Regulation Of Myeloid Cell Differentiation Histone Ubiquitination Positive Regulation Of Transcription, DNA-templated Regulation Of Myeloid Cell Differentiation Nitrogen Compound Metabolic Process Endoderm Formation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Stem Cell Development RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Wnt Signaling Pathway Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Endoderm Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Stem Cell Differentiation Gastrulation Regulation Of Cell Differentiation Regulation Of Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Cell Differentiation RNA Metabolic Process Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		abstract advancements ascribed attitude azacitidine challenging changing choices conditioning curative decitabine feasible haploidentical hematologists hypomethylating idh2 incurable optimize overview profoundly renders sf3b1 sibling spite stratify tet2 transplant video wider	allow arf cdkn2 chromosomal comprehensive correlates downregulation enable epigenetic epigenomic grades hox hypermethylation hypomethylation inactivates individualized meningioma meningiomas modifications object p14 pertaining profiling thorough timp3 tp73 tumorigenesis upregulation wnk2
Tagcloud (Difference) ?		abstract advancements ascribed attitude azacitidine challenging changing choices conditioning curative decitabine feasible haploidentical hematologists hypomethylating idh2 incurable optimize overview profoundly renders sf3b1 sibling spite stratify tet2 transplant video wider	allow arf cdkn2 chromosomal comprehensive correlates downregulation enable epigenetic epigenomic grades hox hypermethylation hypomethylation inactivates individualized meningioma meningiomas modifications object p14 pertaining profiling thorough timp3 tp73 tumorigenesis upregulation wnk2
Tagcloud (Intersection) ?