TMEM252 and LBX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM252	LBX1
Description		transmembrane protein 252	ladybird homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process		Heart Looping Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Muscle Organ Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Spinal Cord Motor Neuron Differentiation Cell Differentiation Neuron Fate Commitment Neuron Fate Determination Negative Regulation Of Glutamatergic Neuron Differentiation Glutamatergic Neuron Differentiation
Pathways
Drugs
Diseases
GWAS			Adolescent idiopathic scoliosis ( 26211971 30395268 31417091) Metabolite levels ( 23823483) Refractive error ( 32231278) Scoliosis ( 22019779) Severe insulin-resistant type 2 diabetes ( 34737425)
Interacting Genes		5 interacting genes: LBX1 NEDD4 SLC10A6 TMEM147 YAP1	23 interacting genes: AIPL1 DES EFEMP2 EIF5A FAM221B FAM9B IQGAP1 KANK2 KIF5B KIFC3 KRTAP5-6 KRTAP9-2 MAB21L3 PHF1 PRPF31 QRICH1 RBL2 TBCEL TMEM252 TSSK3 UBTFL1 WNK3 ZNF483
Entrez ID		169693	10660
HPRD ID		18569	09178
Ensembl ID		ENSG00000181778	ENSG00000138136
Uniprot IDs		Q8N6L7	P52954
PDB IDs
Enriched GO Terms of Interacting Partners?		Proline-rich Region Binding Tube Morphogenesis Mesenchyme Development Formation Of Structure Involved In A Symbiotic Process Enterocyte Differentiation Embryonic Heart Tube Morphogenesis Negative Regulation Of Glutamatergic Neuron Differentiation Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Epithelial Tube Morphogenesis Channel Inhibitor Activity Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Sodium Ion Transport Cellular Response To Radiation Phosphothreonine Residue Binding Lateral Mesoderm Development TEAD-YAP Complex Cardiac Muscle Tissue Regeneration Protein Localization To Nuclear Inner Membrane Nuclear Receptor-mediated Corticosteroid Signaling Pathway Bile Acid:sodium Symporter Activity Phosphoserine Residue Binding Beta-2 Adrenergic Receptor Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Transcription Regulator Complex Bud Elongation Involved In Lung Branching Sodium Channel Inhibitor Activity Paraxial Mesoderm Development Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Potassium Ion Export Across Plasma Membrane Progesterone Receptor Signaling Pathway Endocardial Cushion Development Potassium Channel Inhibitor Activity Branch Elongation Of An Epithelium Intestinal Epithelial Cell Development Regulation Of Nephron Tubule Epithelial Cell Differentiation Notochord Development Female Germ Cell Nucleus Intestinal Epithelial Cell Differentiation Morphogenesis Of An Epithelium Multi-pass Transmembrane Protein Insertion Into ER Membrane Multi-pass Translocon Complex Neuron Fate Determination Negative Regulation Of Sodium Ion Transport Protein Localization To Nuclear Envelope Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Columnar/cuboidal Epithelial Cell Development Interleukin-6-mediated Signaling Pathway Glutamatergic Neuron Differentiation
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