CFD and SERPINF2

Number of citations of the paper that reports this interaction (PubMedID 12080056)
0

Data Source:
HPRD (in vitro)

		CFD	SERPINF2
Description		complement factor D	serpin family F member 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Protein Homodimerization Activity
	Biological Process	Immune System Process Proteolysis Complement Activation Complement Activation, Alternative Pathway Response To Bacterium Zymogen Activation Innate Immune Response Protein Maturation	Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Acute-phase Response Negative Regulation Of Plasminogen Activation Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Coagulation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Platelet degranulation Alternative complement activation Neutrophil degranulation	Platelet degranulation Dissolution of Fibrin Clot
Drugs		2-Aminobenzyl alcohol 3,4-Dichloroisocoumarin	Ocriplasmin Copper
Diseases		Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency	Alpha-2-plasmin inhibitor (a2-PI) deficiency
GWAS		High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494)	Calcium levels ( 20705733 24068962) Hodgkin's lymphoma ( 34216518) Serum albumin levels ( 23022100 29403010) Severe insulin-deficient type 2 diabetes ( 34737425) Urate levels ( 31578528)
Interacting Genes		2 interacting genes: HDHD2 SERPINF2	17 interacting genes: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2
Entrez ID		1675	5345
HPRD ID		00600	02029
Ensembl ID		ENSG00000197766	ENSG00000167711
Uniprot IDs		A6XNE2 K7ERG9 P00746	P08697
PDB IDs		1BIO 1DFP 1DIC 1DST 1DSU 1FDP 1HFD 2XW9 2XWA 2XWB 4CBN 4CBO 4D9R 5FBE 5FBI 5FCK 5MT0 5MT4 5NAR 5NAT 5NAW 5NB6 5NB7 5NBA 5TCA 5TCC 6FTY 6FTZ 6FUG 6FUH 6FUI 6FUJ 6FUT 6QMR 6QMT 6VMJ 6VMK 8D95 8DEA 8DG6
Enriched GO Terms of Interacting Partners?		Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Positive Regulation Of Transforming Growth Factor Beta Production Fibrinogen Complex Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Fibrinolysis Negative Regulation Of Plasminogen Activation Positive Regulation Of Blood Coagulation Negative Regulation Of Fibrinolysis Fibrinolysis Regulation Of Plasminogen Activation Negative Regulation Of Protein Processing Negative Regulation Of Protein Maturation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Collagen Biosynthetic Process Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Coagulation Acute-phase Response Regulation Of Collagen Biosynthetic Process Regulation Of Collagen Metabolic Process Regulation Of Systemic Arterial Blood Pressure Endopeptidase Inhibitor Activity Negative Regulation Of Coagulation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Collagen Fibril Organization Positive Regulation Of Wound Healing Platelet Alpha Granule Lumen Regulation Of Protein Processing Regulation Of Protein Maturation Positive Regulation Of Actin Filament Bundle Assembly Acute Inflammatory Response Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Phosphatase Activity Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Stress Fiber Assembly Blood Vessel Morphogenesis Positive Regulation Of JNK Cascade Protease Binding Peptidase Inhibitor Activity Renal System Process Blood Microparticle Extracellular Exosome Regulation Of Wound Healing	Serine-type Peptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Protein Processing Protein Maturation Extracellular Space Proteolysis Extracellular Region Zymogen Activation Blood Coagulation Coagulation Hydrolase Activity Hemostasis Extracellular Matrix Negative Regulation Of Blood Coagulation Plasminogen Activation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Protein Metabolic Process Platelet Alpha Granule Lumen Regulation Of Fibrinolysis Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Fibrinolysis Secretory Granule Positive Regulation Of Fibrinolysis Blood Microparticle Biological Process Involved In Interaction With Symbiont Regulation Of Body Fluid Levels Extracellular Exosome Regulation Of Wound Healing Extracellular Matrix Disassembly Protein-glutamine Gamma-glutamyltransferase Activity Regulation Of Response To Wounding Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Fibrinolysis Endopeptidase Activity Macromolecule Metabolic Process Peptide Cross-linking Protein Activation Cascade Negative Regulation Of Protein Maturation Positive Regulation Of Blood Coagulation Digestion Cell Surface Positive Regulation Of Coagulation Killing By Host Of Symbiont Cells Response To Bacterium Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Serine-type Aminopeptidase Activity
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