CFD and SERPINF2

Number of citations of the paper that reports this interaction (PMID 12080056)
3

Data Source:
HPRD (in vitro)

		CFD	SERPINF2
Gene Name		complement factor D (adipsin)	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Extracellular Vesicular Exosome	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Platelet Degranulation Proteolysis Complement Activation Complement Activation, Alternative Pathway Blood Coagulation Platelet Activation Innate Immune Response	Regulation Of Blood Vessel Size By Renin-angiotensin Platelet Degranulation Acute-phase Response Blood Coagulation Response To Organic Substance Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Platelet Activation Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Alternative complement activation Complement cascade Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Initial triggering of complement Innate Immune System	Response to elevated platelet cytosolic Ca2+ Platelet degranulation Dissolution of Fibrin Clot Platelet activation, signaling and aggregation
Drugs		Isatoic Anhydride 3,4-Dichloroisocoumarin	Ocriplasmin
Diseases
GWAS			Calcium levels ( 20705733) Serum albumin level ( 23022100)
Protein-Protein Interactions		2 interactors: HDHD2 SERPINF2	17 interactors: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2
Entrez ID		1675	5345
HPRD ID		00600	02029
Ensembl ID			ENSG00000167711
Uniprot IDs		P00746	P08697
PDB IDs		1BIO 1DFP 1DIC 1DST 1DSU 1FDP 1HFD 2XW9 2XWA 2XWB 4D9R
Enriched GO Terms of Interacting Partners?		Regulation Of Blood Vessel Size By Renin-angiotensin Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Plasminogen Activation Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Positive Regulation Of Transforming Growth Factor Beta Production Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Fibrinolysis Positive Regulation Of Blood Coagulation Regulation Of Collagen Metabolic Process Acute-phase Response Positive Regulation Of Coagulation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Wound Healing Positive Regulation Of Actin Filament Bundle Assembly Negative Regulation Of Blood Coagulation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Coagulation Collagen Fibril Organization Regulation Of Stress Fiber Assembly Negative Regulation Of Wound Healing Platelet Degranulation Regulation Of Blood Vessel Size Regulation Of Tube Size Acute Inflammatory Response Regulation Of Systemic Arterial Blood Pressure Renal System Process Regulation Of Blood Coagulation Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of JNK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Wound Healing Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Regulation Of Blood Pressure Regulation Of Stress-activated MAPK Cascade Regulation Of ERK1 And ERK2 Cascade Platelet Activation Positive Regulation Of Cytoskeleton Organization	Extracellular Matrix Disassembly Proteolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Wound Healing Negative Regulation Of Wound Healing Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Response To Wounding Blood Coagulation Hemostasis Protein Metabolic Process Regulation Of Blood Coagulation Regulation Of Wound Healing Regulation Of Body Fluid Levels Positive Regulation Of Fibrinolysis Platelet Activation Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Response To Stress Vesicle-mediated Transport Regulation Of Fibrinolysis Mitochondrial Calcium Ion Homeostasis Cobalamin Metabolic Process Exocytosis Killing Of Cells Of Other Organism Defense Response To Fungus Fibrinolysis Protein Activation Cascade Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cell-substrate Adhesion Response To Fungus Secretion By Cell Immune System Process Peptide Cross-linking Protein Processing Tissue Regeneration Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Blood Coagulation, Common Pathway Blood Coagulation, Common Pathway Regulation Of Cell Adhesion Secretion Collagen Catabolic Process Cellular Calcium Ion Homeostasis Cell Activation Calcium Ion Homeostasis Cellular Homeostasis Positive Regulation Of Signal Transduction Collagen Metabolic Process
Tagcloud ?		293t adjust bypassing compact concatenated constrictions cutting deal deploy deterministic device devices fabricated flowing geometric hek hydrodynamic immobilization inherent mathematical microfluidic path pdms saving serpentine tens thousands trapping works
Tagcloud (Difference) ?		293t adjust bypassing compact concatenated constrictions cutting deal deploy deterministic device devices fabricated flowing geometric hek hydrodynamic immobilization inherent mathematical microfluidic path pdms saving serpentine tens thousands trapping works
Tagcloud (Intersection) ?