CFD and HDHD2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		CFD	HDHD2
Gene Name		complement factor D (adipsin)	haloacid dehalogenase-like hydrolase domain containing 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Extracellular Vesicular Exosome	Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity	Enzyme Binding Metal Ion Binding
	Biological Process	Platelet Degranulation Proteolysis Complement Activation Complement Activation, Alternative Pathway Blood Coagulation Platelet Activation Innate Immune Response	Biological_process
Pathways		Alternative complement activation Complement cascade Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Initial triggering of complement Innate Immune System
Drugs		Isatoic Anhydride 3,4-Dichloroisocoumarin
Diseases
GWAS
Protein-Protein Interactions		2 interactors: HDHD2 SERPINF2	12 interactors: BAI2 CFD CRMP1 DVL1 EPHB6 LUC7L2 MEOX2 MGST2 PIP5K1C SOD2 TARBP2 TRAPPC11
Entrez ID		1675	84064
HPRD ID		00600	13640
Ensembl ID			ENSG00000167220
Uniprot IDs		P00746	Q9H0R4
PDB IDs		1BIO 1DFP 1DIC 1DST 1DSU 1FDP 1HFD 2XW9 2XWA 2XWB 4D9R	3HLT
Enriched GO Terms of Interacting Partners?		Regulation Of Blood Vessel Size By Renin-angiotensin Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Plasminogen Activation Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Positive Regulation Of Transforming Growth Factor Beta Production Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Fibrinolysis Positive Regulation Of Blood Coagulation Regulation Of Collagen Metabolic Process Acute-phase Response Positive Regulation Of Coagulation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Wound Healing Positive Regulation Of Actin Filament Bundle Assembly Negative Regulation Of Blood Coagulation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Coagulation Collagen Fibril Organization Regulation Of Stress Fiber Assembly Negative Regulation Of Wound Healing Platelet Degranulation Regulation Of Blood Vessel Size Regulation Of Tube Size Acute Inflammatory Response Regulation Of Systemic Arterial Blood Pressure Renal System Process Regulation Of Blood Coagulation Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of JNK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Wound Healing Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Regulation Of Blood Pressure Regulation Of Stress-activated MAPK Cascade Regulation Of ERK1 And ERK2 Cascade Platelet Activation Positive Regulation Of Cytoskeleton Organization See more	Axon Guidance Neuron Development Axonogenesis Response To External Stimulus Axon Development Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Nervous System Development Erythrophore Differentiation Age-dependent Response To Reactive Oxygen Species Vasodilation By Acetylcholine Involved In Regulation Of Systemic Arterial Blood Pressure Neuron Projection Development Glutathione Metabolic Process Cell Projection Morphogenesis Generation Of Neurons Cell Part Morphogenesis Neurogenesis MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Cell Development Neurotransmitter Secretion Cell Morphogenesis Convergent Extension Involved In Neural Plate Elongation Targeting Of MRNA For Destruction Involved In RNA Interference Response To Silicon Dioxide Response To Magnetism System Development Secretion By Cell Cell Projection Organization Regulation Of Neurotransmitter Levels Collateral Sprouting Age-dependent Response To Oxidative Stress Production Of SiRNA Involved In RNA Interference Detection Of Oxygen Peptide Metabolic Process Locomotion Convergent Extension Involved In Organogenesis Somite Specification Response To Selenium Ion Ribonucleoprotein Complex Assembly Neurotransmitter Transport Secretion Multicellular Organismal Development Oxygen Homeostasis Pyrimidine Nucleobase Catabolic Process Protein Localization To Microtubule Platelet Activation RNA Interference See more
Tagcloud ?		293t adjust bypassing compact concatenated constrictions cutting deal deploy deterministic device devices fabricated flowing geometric hek hydrodynamic immobilization inherent mathematical microfluidic path pdms saving serpentine tens thousands trapping works
Tagcloud (Difference) ?		293t adjust bypassing compact concatenated constrictions cutting deal deploy deterministic device devices fabricated flowing geometric hek hydrodynamic immobilization inherent mathematical microfluidic path pdms saving serpentine tens thousands trapping works
Tagcloud (Intersection) ?