CFD and HDHD2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		CFD	HDHD2
Description		complement factor D	haloacid dehalogenase like hydrolase domain containing 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Cytoplasm Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Protein Binding Phosphatase Activity Enzyme Binding Metal Ion Binding
	Biological Process	Immune System Process Proteolysis Complement Activation Complement Activation, Alternative Pathway Response To Bacterium Zymogen Activation Innate Immune Response Protein Maturation
Pathways		Platelet degranulation Alternative complement activation Neutrophil degranulation
Drugs		2-Aminobenzyl alcohol 3,4-Dichloroisocoumarin
Diseases		Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency
GWAS		High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494)	Blood protein levels ( 30072576) Fruit consumption ( 32066663)
Interacting Genes		2 interacting genes: HDHD2 SERPINF2	12 interacting genes: ADGRB2 CFD CRMP1 DVL1 EPHB6 LUC7L2 MEOX2 MGST2 PIP5K1C SOD2 TARBP2 TRAPPC11
Entrez ID		1675	84064
HPRD ID		00600	13640
Ensembl ID		ENSG00000197766	ENSG00000167220
Uniprot IDs		A6XNE2 K7ERG9 P00746	Q9H0R4 V9HW73
PDB IDs		1BIO 1DFP 1DIC 1DST 1DSU 1FDP 1HFD 2XW9 2XWA 2XWB 4CBN 4CBO 4D9R 5FBE 5FBI 5FCK 5MT0 5MT4 5NAR 5NAT 5NAW 5NB6 5NB7 5NBA 5TCA 5TCC 6FTY 6FTZ 6FUG 6FUH 6FUI 6FUJ 6FUT 6QMR 6QMT 6VMJ 6VMK 8D95 8DEA 8DG6	3HLT
Enriched GO Terms of Interacting Partners?		Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Positive Regulation Of Transforming Growth Factor Beta Production Fibrinogen Complex Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Fibrinolysis Negative Regulation Of Plasminogen Activation Positive Regulation Of Blood Coagulation Negative Regulation Of Fibrinolysis Fibrinolysis Regulation Of Plasminogen Activation Negative Regulation Of Protein Processing Negative Regulation Of Protein Maturation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Collagen Biosynthetic Process Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Coagulation Acute-phase Response Regulation Of Collagen Biosynthetic Process Regulation Of Collagen Metabolic Process Regulation Of Systemic Arterial Blood Pressure Endopeptidase Inhibitor Activity Negative Regulation Of Coagulation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Collagen Fibril Organization Positive Regulation Of Wound Healing Platelet Alpha Granule Lumen Regulation Of Protein Processing Regulation Of Protein Maturation Positive Regulation Of Actin Filament Bundle Assembly Acute Inflammatory Response Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Phosphatase Activity Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Stress Fiber Assembly Blood Vessel Morphogenesis Positive Regulation Of JNK Cascade Protease Binding Peptidase Inhibitor Activity Renal System Process Blood Microparticle Extracellular Exosome Regulation Of Wound Healing
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