DGCR8 and MEOX2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		DGCR8	MEOX2
Gene Name		DGCR8 microprocessor complex subunit	mesenchyme homeobox 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Microtubule Cytoskeleton	Nucleus Cytoplasm Nuclear Speck
	Molecular Function	Double-stranded RNA Binding Protein Binding Metal Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Gene Expression Primary MiRNA Processing Regulation Of Stem Cell Proliferation	Angiogenesis Somite Specification Transcription, DNA-templated Multicellular Organismal Development Skeletal Muscle Tissue Development Blood Circulation Positive Regulation Of Transcription From RNA Polymerase II Promoter Palate Development Limb Development Neuron Death
Pathways		Regulatory RNA pathways MicroRNA (miRNA) biogenesis
Drugs
Diseases
GWAS			Blood trace element (Zn levels) ( 23720494)
Protein-Protein Interactions		4 interactors: APP DROSHA MEOX2 SRPK1	207 interactors: ADAMTS12 AGPAT1 AHCYL1 AHSA2 ANP32B ARHGEF7 ARNT2 ATG5 ATXN1L BCL2L15 C19orf66 C1orf109 CARD9 CASP14 CCDC103 CCNC CDH9 CEP57L1 CHIC2 CHRD CIAPIN1 CIB3 CNTNAP2 COX1 CPNE6 CPSF4 CRCT1 CSDC2 CSF2 CTNNBL1 CXXC1 DGCR6 DGCR8 DOCK8 DYNLL2 EDF1 EFEMP2 EFNA3 EIF1AD EIF5A EPM2AIP1 ESR2 ESRRG FAM13C FAM3A FAM74A4 FBF1 FOXR1 FUCA2 FUT11 GABRB3 GAGE1 GLO1 GMCL1P1 GMPR2 GNG11 GOLGA8DP GOLGA8EP GOLGA8F GPATCH2L GPSM3 HAT1 HDHD2 HEXIM2 HGF HLA-A HNRNPD HP1BP3 HSPA2 HTR1E IGF2BP3 IGFN1 INPP1 IP6K2 ITM2A KAT5 KIZ KLC4 KLHL38 KRT80 KRT86 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-4 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KTN1 LAMTOR5 LCE1B LCE2A LCE4A LOC153684 LSM2 MAGED1 MAPKBP1 MKRN3 MLLT6 MMP3 MORN3 MRFAP1L1 MSI2 MT1DP MTMR10 MUM1 MVP MYBPC1 NAA10 NALCN NCALD NCK2 ND1 NLGN3 NTF3 OIT3 OSGIN1 P4HA3 PACSIN2 PAGE2 PARK2 PARVG PAX1 PAX3 PCDH9 PCSK5 PGBD1 PIN1 PKIG POM121C PRKAB2 PRR19 PSMB10 PSMC1 PSMD14 PTGER3 RARB RCHY1 RECK RHOJ RMND5A RND2 RPL15 RUNX1T1 SAMM50 SCNM1 SEPP1 SET SIRPB1 SLC48A1 SMAD3 SMARCE1 SPATA1 SPP1 SPRY1 SPRY2 SSX3 STK16 STX11 STX16 SYT17 TBCEL TBX6 TCEA2 TCL6 TCTEX1D1 TDO2 TGFB1 TICAM2 TMEM100 TP53BP1 TRAF6 TRIM41 TRIM42 TTC25 TTC39B TTC9C TULP2 TXLNA UBE3A UBL4A UBL4B UNC45A USE1 VEZF1 VIP WFDC9 XRCC2 ZBED4 ZMAT2 ZNF124 ZNF329 ZNF404 ZNF417 ZNF483 ZNF564 ZNF572 ZNF587 ZNF695
Entrez ID		54487	4223
HPRD ID		09913	02760
Ensembl ID		ENSG00000128191	ENSG00000106511
Uniprot IDs		Q8WYQ5	P50222
PDB IDs		1X47 2YT4 3LE4
Enriched GO Terms of Interacting Partners?		Neuron Death RNA Processing Synaptic Growth At Neuromuscular Junction RNA Metabolic Process Gene Expression Collateral Sprouting In Absence Of Injury Defense Response Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Primary MiRNA Processing Somite Specification Axon Choice Point Recognition Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Neuron Remodeling Sperm Chromatin Condensation RRNA Catabolic Process Regulation Of MiRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process MRNA Processing Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Posttranscriptional Regulation Of Gene Expression MiRNA Metabolic Process Pre-miRNA Processing Segment Specification MRNA Metabolic Process Nitrogen Compound Metabolic Process Cellular Copper Ion Homeostasis Production Of MiRNAs Involved In Gene Silencing By MiRNA Positive Regulation Of Viral Genome Replication Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Spermatid Nucleus Differentiation Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Gene Silencing By MiRNA Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To DsRNA Defense Response To Gram-negative Bacterium RNA Polyadenylation Neuron Recognition Sexual Reproduction Posttranscriptional Gene Silencing	Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cell Death Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Epithelium Development Positive Regulation Of Gene Expression Developmental Process Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Cell Death Regulation Of RNA Biosynthetic Process Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Death Apoptotic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Process Positive Regulation Of DNA Binding RNA Metabolic Process System Development Regulation Of Protein Ubiquitination Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of DNA Binding Myeloid Dendritic Cell Differentiation Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Metabolic Process Multicellular Organismal Development Positive Regulation Of Protein Ubiquitination Myeloid Dendritic Cell Activation
Tagcloud ?		azoospermia biogenesis coding defects dicer1 dissect emphasize endo endonuclease fine germ haploid inactivation infertile infertility meiotic micro mirnas oligo retaining rnas sirnas spermatocyte spermatocytes spermatogenesis spermatozoa terato testicular tuning	activates angiogenic biphasic colocalization colocalizes constructs depend ec ecs homeobox homeodomain homeoprotein hypothesize ikappabbeta immunofluorescence implicate ingrowth modulate modulates normally p65 proangiogenic promoters rela represses secrete stimulates transduced vessels
Tagcloud (Difference) ?		azoospermia biogenesis coding defects dicer1 dissect emphasize endo endonuclease fine germ haploid inactivation infertile infertility meiotic micro mirnas oligo retaining rnas sirnas spermatocyte spermatocytes spermatogenesis spermatozoa terato testicular tuning	activates angiogenic biphasic colocalization colocalizes constructs depend ec ecs homeobox homeodomain homeoprotein hypothesize ikappabbeta immunofluorescence implicate ingrowth modulate modulates normally p65 proangiogenic promoters rela represses secrete stimulates transduced vessels
Tagcloud (Intersection) ?