DGCR8

Description		DGCR8 microprocessor complex subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Postsynaptic Density Nuclear Body Site Of Double-strand Break Microprocessor Complex Glutamatergic Synapse
	Molecular Function	RNA Binding Double-stranded RNA Binding Protein Binding Heme Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Primary MiRNA Binding Protein-RNA Adaptor Activity
	Biological Process	DNA Damage Response Primary MiRNA Processing Regulation Of Stem Cell Proliferation Positive Regulation Of Pre-miRNA Processing
Pathways		MicroRNA (miRNA) biogenesis Transcriptional Regulation by MECP2
Drugs
Diseases
GWAS		Adult body size ( 32376654) Metabolite levels ( 23823483) Serum metabolite levels ( 23093944)
Interacting Genes		6 interacting genes: APP DROSHA MEOX2 RNF10 RNF168 USP51
Entrez ID		54487
HPRD ID		09913
Ensembl ID		ENSG00000128191
Uniprot IDs		Q8WYQ5
PDB IDs		1X47 2YT4 3LE4 5B16 6LXD 6LXE 6V5B 6V5C 7CNC 9ASM 9ASN 9ASO 9ASP 9ASQ
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Regulation Of Primary Metabolic Process Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Regulation Of MiRNA Metabolic Process Amylin Binding Regulation Of Macromolecule Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Defense Response To Gram-positive Bacterium Lipoprotein Particle Regulation Of Cellular Response To Stress Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Nervous System Process Microglia Development Defense Response To Gram-negative Bacterium Positive Regulation Of G Protein-coupled Receptor Internalization Microprocessor Complex Ribonuclease III Activity DNA Repair-dependent Chromatin Remodeling Histone Ubiquitin Ligase Activity Histone H2AK15 Ubiquitin Ligase Activity Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Cell Activation Involved In Immune Response Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Regulation Of Metabolic Process Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Somite Specification Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane
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