TEX44 and DERL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TEX44	DERL1
Description		testis expressed 44	derlin 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Early Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Protein Binding	Protease Binding Signal Recognition Particle Binding Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity MHC Class I Protein Binding Identical Protein Binding Protein-containing Complex Binding ATPase Binding Ubiquitin-specific Protease Binding
	Biological Process		Response To Unfolded Protein Proteasomal Protein Catabolic Process Protein Transport Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Ubiquitination Protein Destabilization Cellular Response To Stress Cellular Response To Unfolded Protein ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization Cellular Response To Misfolded Protein
Pathways			ABC-family proteins mediated transport N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective CFTR causes cystic fibrosis E3 ubiquitin ligases ubiquitinate target proteins AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483)
Interacting Genes		13 interacting genes: APOC1 APP C3orf33 CIDEB COX20 CPT1B DERL1 MICOS13 MPC2 RHBDD2 SYPL1 TIMM17B TMEM14B	32 interacting genes: ABHD4 AMFR APP AQP6 CFTR CIAO2A FCRL4 FFAR2 GAD2 HLA-A KASH5 LMNA LNX1 MELTF REEP4 RETREG3 RHO SCN3B SELENOS SLC10A1 SLC10A6 SLC30A8 SLC7A14 SLC7A8 TCF25 TEX44 TMED8 TMEM31 TMX2 TRIM32 UBXN6 VCP
Entrez ID		165100	79139
HPRD ID		14602	12302
Ensembl ID		ENSG00000177673	ENSG00000136986
Uniprot IDs		Q53QW1	E5RGY0 Q9BUN8
PDB IDs			5GLF 7CZB 7Y4W 7Y53 7Y59
Enriched GO Terms of Interacting Partners?		Mitochondrial Inner Membrane Signal Recognition Particle Binding Very-low-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Plasma Lipoprotein Particle Assembly Intracellular Transport Membrane Mitochondrion Mitochondrial Transmembrane Transport Protein-lipid Complex Assembly Lipoprotein Metabolic Process Mitochondrial Transport Regulation Of Triglyceride Metabolic Process Negative Regulation Of Phosphatidylcholine Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Localization Establishment Of Localization In Cell Endoplasmic Reticulum Unfolded Protein Response Lipid Transport Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Pyruvate Import Into Mitochondria Derlin-1-VIMP Complex Regulation Of Phosphatidylcholine Catabolic Process PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Carnitine O-palmitoyltransferase Activity ERAD Pathway Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Very-low-density Lipoprotein Particle Clearance Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation	Derlin-1 Retrotranslocation Complex Ubiquitin-specific Protease Binding BAT3 Complex Binding ERAD Pathway Bile Acid:sodium Symporter Activity Response To Endoplasmic Reticulum Stress Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Endoplasmic Reticulum Membrane Endoplasmic Reticulum Endoplasmic Reticulum Unfolded Protein Response Protein Binding Membrane Positive Regulation Of Chemokine Production Low-density Lipoprotein Particle Organic Anion Transport Golgi-associated Vesicle Membrane Retrograde Protein Transport, ER To Cytosol Early Endosome Membrane Positive Regulation Of Proteolysis Positive Regulation Of Insulin Secretion Very-low-density Lipoprotein Particle Endoplasmic Reticulum Tubular Network Organization Bile Acid And Bile Salt Transport Endoplasmic Reticulum Tubular Network
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