CTXN3 and CLDN14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CTXN3	CLDN14
Description		cortexin 3	claudin 14
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Endoplasmic Reticulum Plasma Membrane Bicellular Tight Junction Membrane Anchoring Junction
	Molecular Function	Protein Binding	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process		Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Protein-containing Complex Assembly Bicellular Tight Junction Assembly
Pathways			Tight junction interactions
Drugs
Diseases			Deafness, autosomal recessive
GWAS		Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457)	Blood urea nitrogen levels ( 31152163) Bone mineral density ( 24249740) Estimated glomerular filtration rate ( 31015462 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 30598549) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Kidney stones ( 26272126 31729369 19561606) Obsessive-compulsive traits ( 33531474) Red blood cell count ( 32888494) Serum parathyroid hormone levels ( 27927781) Urate levels ( 31578528) Urinary electrolytes (magnesium/calcium ratio) ( 27915449) Urolithiasis ( 30975718)
Interacting Genes		59 interacting genes: ADGRG3 AQP6 AQP9 ATP1B3 BIK BTN2A1 CD300E CD53 CD79A CERS4 CLDN14 CLEC17A CLEC7A CLRN1 COQ9 CPLX4 CREB3L1 CTLA4 EDA ERGIC3 FAM209A FFAR3 FUT7 GJA8 GJB1 GJB5 GPR152 GPR42 GPR61 IFNLR1 KASH5 KIR3DL3 KLRC1 LAPTM4B LDLRAD1 LHFPL5 LSMEM2 MFF MGST2 MTIF3 NCAPH2 OPRD1 OPRM1 PACC1 PLPP5 PVR SCN3B SLC10A2 SPACA1 STOM TLCD4 TM4SF19 TMEM106C TMEM167B TMEM179B TMEM31 TMPRSS2 TMX2 TSPAN12	4 interacting genes: CTXN3 MAL PLEKHA1 PLLP
Entrez ID		613212	23562
HPRD ID		18888	05727
Ensembl ID		ENSG00000205279	ENSG00000159261
Uniprot IDs		Q4LDR2	O95500
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Protein Binding PH-gated Chloride Channel Activity Connexin Complex Gap Junction Channel Activity Gap Junction Immune Response-activating Cell Surface Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Opioid Receptor Activity G Protein-coupled Receptor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway G Protein-coupled Opioid Receptor Signaling Pathway Immune System Process Immune Response-regulating Signaling Pathway	Structural Constituent Of Myelin Sheath Protein Insertion Into Plasma Membrane Myelination Axon Ensheathment Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Regulation Of Transcytosis Membrane Raft Polarization Positive Regulation Of Protein Folding Peptide-O-fucosyltransferase Activity Protein Localization To Paranode Region Of Axon Compact Myelin Peptidase Activator Activity Involved In Apoptotic Process Protein O-linked Glycosylation Via Fucose Membrane Raft Distribution Granular Component Protein Localization To Axon Schmidt-Lanterman Incisure Membrane Raft Membrane Raft Localization Regulation Of Protein Folding Fucosylation Fucosyltransferase Activity Luteinization Leydig Cell Differentiation
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