CLEC14A and MGST2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLEC14A	MGST2
Description		C-type lectin domain containing 14A	microsomal glutathione S-transferase 2
Image		No pdb structure
GO Annotations	Cellular Component	External Side Of Plasma Membrane Membrane Extracellular Matrix	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Carbohydrate Binding Extracellular Matrix Binding Extracellular Matrix Protein Binding	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Oxidoreductase Activity Transferase Activity Lyase Activity Identical Protein Binding Glutathione Binding
	Biological Process	Lymphangiogenesis Sprouting Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Cell Migration Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Vascular Endothelial Growth Factor Receptor-3 Signaling Pathway	Lipid Metabolic Process Leukotriene Metabolic Process Glutathione Biosynthetic Process Leukotriene Biosynthetic Process Response To Lipopolysaccharide Carboxylic Acid Biosynthetic Process Membrane Lipid Catabolic Process Positive Regulation Of Inflammatory Response Cellular Oxidant Detoxification
Pathways			Glutathione conjugation Aflatoxin activation and detoxification
Drugs		Resveratrol	Glutathione
Diseases
GWAS		Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Two-hour glucose ( 34059833) Type 2 diabetes ( 30297969 32499647) Type 2 diabetes (age of onset) ( 28060188)	Metabolite levels ( 23823483)
Interacting Genes		13 interacting genes: ATP6V0C CLDN19 CLDN4 CYB561D2 EMD LHFPL5 MALL MGST2 MS4A1 PMP22 TMEM243 TSPAN2 VAMP3	23 interacting genes: ASIC1 BCL2L10 BCL2L2 C3orf52 CCL3L3 CLEC14A CREB3 CREB3L1 CTXN3 DNAJC30 GIMAP5 GJA8 GPX8 HDHD2 PLN PNKP SEC22A SEC22B SGCB STX8 TMEM167B TMEM207 VAMP3
Entrez ID		161198	4258
HPRD ID		10711	03436
Ensembl ID		ENSG00000176435	ENSG00000085871
Uniprot IDs		Q86T13	Q99735
PDB IDs			6SSR 6SSS 6SSU 6SSW
Enriched GO Terms of Interacting Partners?		Membrane Paracellular Transport Myelination Axon Ensheathment Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Plasma Membrane Tight Junction Renal Absorption Bicellular Tight Junction Assembly Tight Junction Organization Tight Junction Assembly TMEM240-body	SNAP Receptor Activity Membrane Membrane Fusion
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