DGKQ and NOTCH2NLA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DGKQ	NOTCH2NLA
Description		diacylglycerol kinase theta	notch 2 N-terminal like A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Vesicle Membrane Membrane Nuclear Matrix Nuclear Speck Synapse Presynapse Postsynapse Glutamatergic Synapse	Extracellular Region Cytoplasm
	Molecular Function	Nucleotide Binding ATP-dependent Diacylglycerol Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Kinase Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding Phospholipase Binding Metal Ion Binding Alkylglycerol Kinase Activity DNA-binding Transcription Factor Binding	Notch Binding Calcium Ion Binding Protein Binding
	Biological Process	Regulation Of Gluconeogenesis Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Platelet Activation Intracellular Signal Transduction Diacylglycerol Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation Response To CAMP Thrombin-activated Receptor Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Regulation Of Cholesterol Metabolic Process Regulation Of Synaptic Vesicle Endocytosis Cellular Response To Bile Acid Regulation Of TORC1 Signaling Regulation Of Cortisol Biosynthetic Process Regulation Of Progesterone Biosynthetic Process	Notch Signaling Pathway Cerebral Cortex Development Cell Differentiation Positive Regulation Of Notch Signaling Pathway
Pathways		Effects of PIP2 hydrolysis	NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus Expression of NOTCH2NL genes
Drugs		alpha-Tocopherol succinate
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) Idiopathic inflammatory myopathy ( 26362759) Limited cutaneous systemic scleroderma ( 29293537) Parkinson's disease ( 20070850 32310270 28892059 25064009 22451204 22438815) Parkinson's disease (familial) ( 18985386) Primary biliary cholangitis ( 26394269) Sjögren's syndrome ( 24097067) Systemic lupus erythematosus ( 28714469 33272962) Systemic sclerosis ( 29293537 31672989) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Triglyceride levels ( 32203549) Waist circumference ( 31928498) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		4 interacting genes: HOXA1 NBPF19 NOTCH2NLA RHOA	361 interacting genes: ACY3 ADAM12 ADAMTSL3 ADAMTSL4 ADAMTSL5 ADCK5 AGXT ALDH16A1 ALDH3B1 ALPI ALPP ANKS1A AQP1 AQP5 ARID3A ASPSCR1 ATG9A ATP5F1D BCAM BCL6B BLCAP BMP7 BRME1 C11orf87 CA6 CARHSP1 CATSPER1 CCDC26 CCDC93 CCER1 CD164 CDK5R1 CELF5 CERK CHCHD3 CHDH CHIC2 CHRD CHRNG CLDN2 CLEC18A CNNM3 COL8A1 CRACR2A CRCT1 CREB5 CRH CRY2 CSF1 CST2 CST9L CTNNBIP1 CTSG CTSZ CXCL16 CXCL5 CYP21A2 CYSRT1 DAGLB DALRD3 DBH DGCR6 DGKQ DHRS1 DMRT3 DNAL4 DOCK2 DRD5 EFNA3 EIF4E2 ELANE EMC7 EPHB6 ESR2 F10 FAAH FADS2 FAM124B FAM221A FAM74A4 FAM90A1 FARS2 FASLG FBXL18 FBXW5 FOXB1 FRS3 FTHL17 FZD10 GABRD GARIN5B GARIN6 GATA2 GEM GFOD1 GIP GLP1R GLRX3 GLYAT GNAI2 GNE GNMT GSTP1 GTF3C5 H2AC15 HAPLN2 HBA1 HBA2 HBZ HCK HHEX HOXA1 HOXB9 HOXC8 HPCAL1 HSBP1 HSD3B7 HSPA12B HSPBP1 HSPD1 ICAM4 IFI30 IGSF8 IL10 IL2RG INO80B INPP5D INS ITGB2 ITGB4 ITGB5 JOSD1 KCNS2 KCTD15 KIF1A KLHL38 KLK8 KPRP KRT20 KRT83 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP13-3 KRTAP13-4 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP3-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LIMS2 LIN7A LINC00526 LINC00656 LMNTD2 LMO2 LNX1 LONRF3 LRCH4 LRFN4 LYVE1 MACO1 MAPKBP1 MARK4 MATN3 MELTF MOS MRGBP MRPL40 MTA1 MVP MXD3 MXI1 MYO15B MYPOP NAB2 NAXD NECTIN2 NECTIN3 NEDD9 NEU2 NMU NMUR2 NPBWR2 NPDC1 NPPB NR1D2 NTM NTN4 NUBP2 NUFIP2 OLFM2 OTX1 P2RX4 P2RX7 P2RY6 PCED1A PCED1B PCSK5 PDE9A PGAP6 PGLS PHLDA1 PID1 PIGS PLEKHN1 PLPP2 PLSCR4 POLR2G POM121L8P POMGNT2 PRF1 PRKAA2 PRPF31 PRPS2 PRR19 PRR35 PSMA1 PSMG2 PTGER3 PTK7 PTPMT1 PTPN23 PVR QPRT R3HDM2 RAB3IL1 RAMP3 RASD1 RCHY1 RECK RET RGL2 RNF111 RPS19BP1 RPS28 RTN4RL1 SCNM1 SDCBP SELENOM SEMA3B SEMA4C SHANK3 SHFL SLC22A23 SLC22A5 SLC23A1 SLC25A10 SLC25A6 SLC43A2 SLC5A5 SLC68A1 SLC6A20 SMARCD2 SMARCE1 SMCP SMOC1 SNAI1 SPATA24 SPATA31J1 SPATA8 SPG7 SPINK2 SPPL2C SPRY1 STAC STK16 TAPBPL TBC1D10C TBC1D16 TEDC2 THAP7 THEMIS2 TINAGL1 TLE5 TMEFF2 TMEM150A TMEM231 TMEM41A TMIE TNIP3 TNK2 TNP2 TNS2 TRAPPC14 TRIM27 TRIM42 TROAP TRPV6 TSPAN4 TTPA TXNDC5 UBQLN4 UTP23 UXT VASN WDR25 WT1-AS XCL2 YIPF3 ZDHHC1 ZFTRAF1 ZFYVE21 ZNF124 ZNF319 ZNF32 ZNF330 ZNF408 ZNF414 ZNF417 ZNF439 ZNF440 ZNF446 ZNF497 ZNF580 ZNF581 ZNF587 ZNF648 ZNF672 ZNF688 ZNF786 ZNF837
Entrez ID		1609	388677
HPRD ID		03127	14833
Ensembl ID		ENSG00000145214	ENSG00000264343
Uniprot IDs		A0A140VKC1 P52824 Q59FF7	A0A8I5KR58 Q7Z3S9
PDB IDs
Enriched GO Terms of Interacting Partners?		Aortic Valve Formation Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Mitotic Cleavage Furrow Formation Skeletal Muscle Satellite Cell Migration Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Beta Selection Apolipoprotein A-I-mediated Signaling Pathway Positive Regulation Of Lipase Activity Cleavage Furrow Formation Tube Morphogenesis Regulation Of Systemic Arterial Blood Pressure By Endothelin Bone Trabecula Morphogenesis Negative Regulation Of Cell Size Apical Junction Assembly Ossification Involved In Bone Maturation Negative Regulation Of Cellular Respiration Roundabout Signaling Pathway Negative Regulation Of Oxidative Phosphorylation Forebrain Radial Glial Cell Differentiation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Outer Ear Morphogenesis Embryonic Neurocranium Morphogenesis Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Podosome Assembly Negative Regulation Of Motor Neuron Apoptotic Process Endothelial Tube Morphogenesis Heart Valve Formation Radial Glial Cell Differentiation Regulation Of Modification Of Postsynaptic Structure Motor Neuron Apoptotic Process Regulation Of Podosome Assembly Regulation Of Motor Neuron Apoptotic Process Cellular Response To Chemokine Positive Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Establishment Of Epithelial Cell Apical/basal Polarity Apical Junction Complex Establishment Of Apical/basal Cell Polarity Regulation Of Aerobic Respiration Establishment Of Monopolar Cell Polarity Regulation Of Osteoblast Proliferation Establishment Or Maintenance Of Monopolar Cell Polarity Androgen Receptor Signaling Pathway Regulation Of Modification Of Synaptic Structure T Cell Selection Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell	Intermediate Filament Keratin Filament Protein Binding Keratinization Epidermis Development Hair Cycle Identical Protein Binding Carbon Dioxide Transport Nitric Oxide Transport Purinergic Nucleotide Receptor Signaling Pathway
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