DGKQ and NBPF19

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DGKQ	NBPF19
Description		diacylglycerol kinase theta	NBPF member 19
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Vesicle Membrane Membrane Nuclear Matrix Nuclear Speck Synapse Presynapse Postsynapse Glutamatergic Synapse	Cytoplasm
	Molecular Function	Nucleotide Binding ATP-dependent Diacylglycerol Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Kinase Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding Phospholipase Binding Metal Ion Binding Alkylglycerol Kinase Activity DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of Gluconeogenesis Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Platelet Activation Intracellular Signal Transduction Diacylglycerol Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation Response To CAMP Thrombin-activated Receptor Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Regulation Of Cholesterol Metabolic Process Regulation Of Synaptic Vesicle Endocytosis Cellular Response To Bile Acid Regulation Of TORC1 Signaling Regulation Of Cortisol Biosynthetic Process Regulation Of Progesterone Biosynthetic Process
Pathways		Effects of PIP2 hydrolysis
Drugs		alpha-Tocopherol succinate
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) Idiopathic inflammatory myopathy ( 26362759) Limited cutaneous systemic scleroderma ( 29293537) Parkinson's disease ( 20070850 32310270 28892059 25064009 22451204 22438815) Parkinson's disease (familial) ( 18985386) Primary biliary cholangitis ( 26394269) Sjögren's syndrome ( 24097067) Systemic lupus erythematosus ( 28714469 33272962) Systemic sclerosis ( 29293537 31672989) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Triglyceride levels ( 32203549) Waist circumference ( 31928498) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Serum uric acid levels ( 30993211)
Interacting Genes		4 interacting genes: HOXA1 NBPF19 NOTCH2NLA RHOA	229 interacting genes: ADAM12 ADAMTSL4 AGXT ALDH16A1 ALPP ANKS1A AQP1 ATG9A ATP5F1D BCAM BMP7 BRME1 CARHSP1 CATSPER1 CCER1 CD164 CELF5 CERK CHCHD3 CHIC2 CHRD CHRNG CNNM3 COL8A1 CREB5 CRH CRY2 CST2 CST9L CTNNBIP1 CTSZ CXCL16 CYP21A2 CYSRT1 DAGLB DALRD3 DBH DGKQ DHRS1 DMRT3 DOCK2 DRD5 EMC7 F10 FADS2 FAM221A FAM90A1 FBXW5 FRS3 FTHL17 FZD10 GARIN6 GLP1R GLYAT GNE GSTP1 HAPLN2 HBA1 HBA2 HBZ HCK HHEX HOXA1 HOXB9 HOXC8 HPCAL1 HSPA12B ICAM4 IGSF8 IL10 INO80B INS ITGB2 ITGB4 ITGB5 JOSD1 KCNS2 KCTD15 KLHL38 KLK8 KPRP KRT83 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP13-3 KRTAP13-4 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LMNTD2 LNX1 LRFN4 LYVE1 MACO1 MAPKBP1 MELTF MOS MRGBP MRPL40 MTA1 MXD3 MXI1 MYO15B MYPOP NECTIN2 NECTIN3 NEDD9 NMU NPDC1 NR1D2 NTM NTN4 NUFIP2 OLFM2 OTX1 P2RX4 P2RX7 P2RY6 PCSK5 PGAP6 PHLDA1 PIGS PLEKHN1 PRF1 PRR19 PRR35 PSMA1 PTK7 PTPMT1 PVR R3HDM2 RAB3IL1 RAMP3 RASD1 RECK RNF111 RPS19BP1 RTN4RL1 SCNM1 SEMA3B SEMA4C SHFL SLC22A5 SLC23A1 SLC43A2 SLC5A5 SLC68A1 SLC6A20 SMCP SPATA24 SPATA8 SPG7 SPPL2C SPRY1 STAC STK16 TAPBPL TCAF1 THAP7 TLE5 TMEFF2 TMEM150A TMIE TNIP3 TNS2 TRAPPC14 TRIM42 TROAP TSPAN4 TTPA UTP23 UXT VASN WDR25 ZDHHC1 ZFTRAF1 ZNF124 ZNF319 ZNF330 ZNF408 ZNF414 ZNF417 ZNF440 ZNF446 ZNF497 ZNF580 ZNF581 ZNF587 ZNF648 ZNF672 ZNF786 ZNF837
Entrez ID		1609	101060226
HPRD ID		03127
Ensembl ID		ENSG00000145214	ENSG00000271383
Uniprot IDs		A0A140VKC1 P52824 Q59FF7	A0A087WUL8
PDB IDs
Enriched GO Terms of Interacting Partners?		Aortic Valve Formation Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Mitotic Cleavage Furrow Formation Skeletal Muscle Satellite Cell Migration Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Beta Selection Apolipoprotein A-I-mediated Signaling Pathway Positive Regulation Of Lipase Activity Cleavage Furrow Formation Tube Morphogenesis Regulation Of Systemic Arterial Blood Pressure By Endothelin Bone Trabecula Morphogenesis Negative Regulation Of Cell Size Apical Junction Assembly Ossification Involved In Bone Maturation Negative Regulation Of Cellular Respiration Roundabout Signaling Pathway Negative Regulation Of Oxidative Phosphorylation Forebrain Radial Glial Cell Differentiation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Outer Ear Morphogenesis Embryonic Neurocranium Morphogenesis Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Podosome Assembly Negative Regulation Of Motor Neuron Apoptotic Process Endothelial Tube Morphogenesis Heart Valve Formation Radial Glial Cell Differentiation Regulation Of Modification Of Postsynaptic Structure Motor Neuron Apoptotic Process Regulation Of Podosome Assembly Regulation Of Motor Neuron Apoptotic Process Cellular Response To Chemokine Positive Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Establishment Of Epithelial Cell Apical/basal Polarity Apical Junction Complex Establishment Of Apical/basal Cell Polarity Regulation Of Aerobic Respiration Establishment Of Monopolar Cell Polarity Regulation Of Osteoblast Proliferation Establishment Or Maintenance Of Monopolar Cell Polarity Androgen Receptor Signaling Pathway Regulation Of Modification Of Synaptic Structure T Cell Selection Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell	Intermediate Filament Keratin Filament Protein Binding Keratinization Epidermis Development Hair Cycle Tissue Development Nitric Oxide Transport Carbon Dioxide Transport
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