DGKQ

Name	diacylglycerol kinase theta
Structure	No pdb structure
Interactors	4 interactors: HOXA1 NBPF19 NOTCH2NLA RHOA
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Vesicle Membrane Membrane Nuclear Matrix Nuclear Speck Synapse Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding ATP-dependent Diacylglycerol Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Kinase Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding Phospholipase Binding Metal Ion Binding Alkylglycerol Kinase Activity DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of Gluconeogenesis Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Platelet Activation Intracellular Signal Transduction Diacylglycerol Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation Response To CAMP Thrombin-activated Receptor Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Regulation Of Cholesterol Metabolic Process Regulation Of Synaptic Vesicle Endocytosis Cellular Response To Bile Acid Regulation Of TORC1 Signaling Regulation Of Cortisol Biosynthetic Process Regulation Of Progesterone Biosynthetic Process
Pathways	Effects of PIP2 hydrolysis
Drugs	alpha-Tocopherol succinate
GWAS	Apolipoprotein A1 levels ( 32203549 ) HDL cholesterol levels ( 32203549 ) High density lipoprotein cholesterol levels ( 31928498 ) Idiopathic inflammatory myopathy ( 26362759 ) Limited cutaneous systemic scleroderma ( 29293537 ) Parkinson's disease ( 20070850 32310270 28892059 25064009 22451204 22438815 ) Parkinson's disease (familial) ( 18985386 ) Primary biliary cholangitis ( 26394269 ) Sjögren's syndrome ( 24097067 ) Systemic lupus erythematosus ( 28714469 33272962 ) Systemic sclerosis ( 29293537 31672989 ) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655 ) Triglyceride levels ( 32203549 ) Waist circumference ( 31928498 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Entrez ID	1609
HPRD ID	03127
Ensembl ID	ENSG00000145214
Uniprot IDs	A0A140VKC1 P52824 Q59FF7
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Aortic Valve Formation Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Mitotic Cleavage Furrow Formation Skeletal Muscle Satellite Cell Migration Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Beta Selection Apolipoprotein A-I-mediated Signaling Pathway Positive Regulation Of Lipase Activity Cleavage Furrow Formation Tube Morphogenesis Regulation Of Systemic Arterial Blood Pressure By Endothelin Bone Trabecula Morphogenesis Negative Regulation Of Cell Size Apical Junction Assembly Ossification Involved In Bone Maturation Negative Regulation Of Cellular Respiration Roundabout Signaling Pathway Negative Regulation Of Oxidative Phosphorylation Forebrain Radial Glial Cell Differentiation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Outer Ear Morphogenesis Embryonic Neurocranium Morphogenesis Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Podosome Assembly Negative Regulation Of Motor Neuron Apoptotic Process Endothelial Tube Morphogenesis Heart Valve Formation Radial Glial Cell Differentiation Regulation Of Modification Of Postsynaptic Structure Motor Neuron Apoptotic Process Regulation Of Podosome Assembly Regulation Of Motor Neuron Apoptotic Process Cellular Response To Chemokine Positive Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Establishment Of Epithelial Cell Apical/basal Polarity Apical Junction Complex Establishment Of Apical/basal Cell Polarity Regulation Of Aerobic Respiration Establishment Of Monopolar Cell Polarity Regulation Of Osteoblast Proliferation Establishment Or Maintenance Of Monopolar Cell Polarity Androgen Receptor Signaling Pathway Regulation Of Modification Of Synaptic Structure T Cell Selection Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell