NKX2-3 and SRF

Number of citations of the paper that reports this interaction (PMID 11457859)
4

Data Source:
HPRD (in vivo)

		NKX2-3	SRF
Gene Name		NK2 homeobox 3	serum response factor (c-fos serum response element-binding transcription factor)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Nucleus	Nuclear Chromatin Nucleus Cytoplasm
	Molecular Function	Molecular_function Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Serum Response Element Binding Chromatin DNA Binding Protein Homodimerization Activity
	Biological Process	Leukocyte Homeostasis Plasma Cell Differentiation Transcription, DNA-templated Triglyceride Metabolic Process Biological_process Gland Morphogenesis Macrophage Differentiation Regulation Of Cell Proliferation Odontogenesis Of Dentin-containing Tooth CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Lymph Node Development Spleen Development Peyer's Patch Development Post-embryonic Digestive Tract Morphogenesis Leukocyte Migration	Patterning Of Blood Vessels Response To Hypoxia Mesoderm Formation Neuron Migration Trophectodermal Cell Differentiation Heart Looping Morphogenesis Of An Epithelial Sheet Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Transcription From RNA Polymerase II Promoter Cell-matrix Adhesion Heart Development Long-term Memory Negative Regulation Of Cell Proliferation Associative Learning Response To Toxic Substance Response To Hormone Epithelial Structure Maintenance Positive Regulation Of Transcription Via Serum Response Element Binding Hippocampus Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Contractile Actin Filament Bundle Assembly Regulation Of Cell Adhesion Platelet Activation Platelet Formation Negative Regulation Of Cell Migration Neuron Projection Development Regulation Of Water Loss Via Skin Response To Cytokine Megakaryocyte Development Dorsal Aorta Morphogenesis MRNA Transcription From RNA Polymerase II Promoter Stress Fiber Assembly Skin Morphogenesis Positive Thymic T Cell Selection Sarcomere Organization Positive Regulation Of Cell Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Transcription By Glucose Muscle Cell Cellular Homeostasis Developmental Growth Neuron Development Erythrocyte Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Filopodium Assembly Cardiac Myofibril Assembly Angiogenesis Involved In Wound Healing Hematopoietic Stem Cell Differentiation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Long Term Synaptic Depression Heart Trabecula Formation Cardiac Vascular Smooth Muscle Cell Differentiation Eyelid Development In Camera-type Eye Tight Junction Assembly Cellular Response To Glucose Stimulus Primitive Streak Formation Epithelial Cell-cell Adhesion Cellular Senescence Negative Regulation Of Beta-amyloid Clearance
Pathways
Drugs
Diseases
GWAS		Crohn's disease ( 18587394 17554261 22412388 17554300 21102463) Dental caries ( 23064961) Inflammatory bowel disease ( 23128233) Red blood cell traits ( 23222517) Ulcerative colitis ( 20228798 20228799)
Protein-Protein Interactions		3 interactors: GTF2A1L SRF ZNF212	72 interactors: ALDH3A1 ASCC1 ASCC2 ASCC3 ATF6 BARX2 CAMK2A CASP3 CASP6 CASP7 CASP8 CASP9 CD63 CEBPB CIRBP CNTN2 CREB1 CREBBP CRIP2 CSNK2A1 ELK1 ELK4 ETV4 FHL1 FHL2 FHL3 FHL5 FLI1 GATA4 GTF2F1 GTF2I HDAC4 HMGA1 HOPX KAT5 KDM6A MAPKAPK2 MINPP1 MKL1 MKL2 MYOCD MYOD1 MYOG NCOA1 NCOA6 NCOR2 NFKB1 NFYA NKX2-3 NKX2-5 NKX3-1 OGT PML PRKDC PRRX1 PYCARD RARG REL RELA RPS6KA1 RXRA RXRG SHBG SP1 SRC SRFBP1 SSRP1 TCF3 TEAD1 TRIM63 UBE2I ZIC3
Entrez ID		159296	6722
HPRD ID		05992	02788
Ensembl ID		ENSG00000119919	ENSG00000112658
Uniprot IDs		Q8TAU0	F5H6V4 P11831
PDB IDs			1HBX 1K6O 1SRS
Enriched GO Terms of Interacting Partners?		Contractile Actin Filament Bundle Assembly Negative Regulation Of Beta-amyloid Clearance Cognition Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Positive Regulation Of Transcription By Glucose Regulation Of Beta-amyloid Clearance Cardiac Vascular Smooth Muscle Cell Differentiation Regulation Of Transcription By Glucose Tangential Migration From The Subventricular Zone To The Olfactory Bulb Transcription, DNA-templated Carbon Catabolite Regulation Of Transcription RNA Biosynthetic Process Dorsal Aorta Morphogenesis Dorsal Aorta Development Positive Thymic T Cell Selection Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Primitive Streak Formation MRNA Transcription From RNA Polymerase II Promoter Hematopoietic Stem Cell Differentiation Cardiac Muscle Cell Myoblast Differentiation Stress Fiber Assembly Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter MRNA Transcription Positive Regulation Of Transcription Via Serum Response Element Binding Coronary Vasculature Development Cardioblast Differentiation Megakaryocyte Development Heart Trabecula Formation Long Term Synaptic Depression Eyelid Development In Camera-type Eye Positive Regulation Of DNA-templated Transcription, Initiation Regulation Of Smooth Muscle Cell Differentiation Angiogenesis Involved In Wound Healing Vascular Smooth Muscle Cell Differentiation Regulation Of Water Loss Via Skin Epithelial Structure Maintenance RNA Metabolic Process Cell Migration Involved In Sprouting Angiogenesis Platelet Formation Platelet Morphogenesis Regulation Of DNA-templated Transcription, Initiation Thymic T Cell Selection Megakaryocyte Differentiation Cardiac Myofibril Assembly Gene Expression Aorta Morphogenesis Trophectodermal Cell Differentiation Muscle Cell Cellular Homeostasis Positive Regulation Of Smooth Muscle Contraction	Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Organ Development Cell Differentiation Developmental Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Tissue Development Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Response To Lipid Anatomical Structure Development Regulation Of Cellular Process Anatomical Structure Morphogenesis System Development Response To Hormone Cellular Response To Organic Substance Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Heart Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Multicellular Organismal Development Negative Regulation Of Gene Expression Response To Steroid Hormone Intracellular Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process
Tagcloud ?			ali bellan biol chem classes coactivator coexpression concluded cooperate creb element finding glutathione harel homologue hybrid mammalian potentiated pull ramirez robin src sre steroid synergistically transactivations transferase trouche yeast
Tagcloud (Difference) ?			ali bellan biol chem classes coactivator coexpression concluded cooperate creb element finding glutathione harel homologue hybrid mammalian potentiated pull ramirez robin src sre steroid synergistically transactivations transferase trouche yeast
Tagcloud (Intersection) ?