NKX2-3 and GTF2A1L

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		NKX2-3	GTF2A1L
Description		NK2 homeobox 3	general transcription factor IIA subunit 1 like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Male Germ Cell Nucleus Nucleus Transcription Factor TFIIA Complex Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Transcription Coactivator Activity Protein Binding
	Biological Process	Cell Fate Specification Leukocyte Homeostasis Plasma Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Triglyceride Metabolic Process Immune Response Post-embryonic Development Gene Expression Gland Morphogenesis Cell Differentiation B Cell Differentiation Macrophage Differentiation Odontogenesis Of Dentin-containing Tooth CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Saliva Secretion Lymph Node Development Spleen Development Mucosa-associated Lymphoid Tissue Development Peyer's Patch Development Digestive Tract Development Post-embryonic Digestive Tract Morphogenesis Regulation Of Epithelial Cell Proliferation Leukocyte Migration	Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of DNA-templated Transcription Cognition
Pathways
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Autoimmune thyroid disease ( 32581359) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal cancer ( 25990418 24737748 30529582) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 17554300 17554261 28067908 25489960 22412388 21102463 18587394) Dental caries ( 23064961) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hypothyroidism ( 27182965) Inflammatory bowel disease ( 28067908 23128233) Leukocyte telomere length ( 31171785) Mean corpuscular hemoglobin ( 27863252) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Pediatric autoimmune diseases ( 26301688) Red blood cell traits ( 23222517) Ulcerative colitis ( 28067908 20228799 20228798)	Adult body size ( 32376654) Hepcidin/ferritin ratio ( 27846281) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Joint mobility (Beighton score) ( 27182965) Laterality in neovascular age-related macular degeneration ( 28775256) Polycystic ovary syndrome ( 21151128)
Interacting Genes		3 interacting genes: GTF2A1L SRF ZNF212	25 interacting genes: ASCL3 ATF4 CEBPE CSNK2A1 CSNK2A2 EMX1 EMX2 GAB1 GTF2A2 HMG20A HOXA5 HOXC11 HOXC9 ID3 MAFF MAFG NKX2-3 PAX9 RBFOX2 SIX6 SUB1 TBP TLX2 TLX3 ZBTB3
Entrez ID		159296	11036
HPRD ID		05992	05640
Ensembl ID		ENSG00000119919	ENSG00000242441
Uniprot IDs		Q8TAU0	Q9UNN4
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-templated Transcription Cognition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By Glucose DNA Binding Vascular Associated Smooth Muscle Cell Differentiation Trachea Cartilage Development Regulation Of Transcription By Glucose Negative Regulation Of Amyloid-beta Clearance Serum Response Element Binding Bronchus Cartilage Development Cardiac Vascular Smooth Muscle Cell Differentiation Carbon Catabolite Regulation Of Transcription Dorsal Aorta Morphogenesis Positive Regulation Of RNA Metabolic Process Primitive Streak Formation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cardiac Muscle Cell Myoblast Differentiation System Process Primary MiRNA Binding Positive Regulation Of DNA-templated Transcription Lung Smooth Muscle Development Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nervous System Process Tangential Migration From The Subventricular Zone To The Olfactory Bulb General Adaptation Syndrome, Behavioral Process Transcription Factor TFIIA Complex Skin Morphogenesis Positive Thymic T Cell Selection Heart Trabecula Formation Positive T Cell Selection Eyelid Development In Camera-type Eye Neuron Projection Development Cardiac Myofibril Assembly Cardioblast Differentiation Long-term Synaptic Depression Face Development Angiogenesis Involved In Wound Healing Trophectodermal Cell Differentiation Positive Regulation Of Biosynthetic Process Regulation Of Amyloid-beta Clearance Platelet Formation Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Filopodium Assembly Smooth Muscle Tissue Development Epithelial Cell-cell Adhesion Thymic T Cell Selection Morphogenesis Of An Epithelial Sheet	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific Double-stranded DNA Binding Regulation Of RNA Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Regulation Of Primary Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Nucleus Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Animal Organ Development Developmental Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Protein Kinase CK2 Complex System Development Positive Regulation Of Metabolic Process Anatomical Structure Morphogenesis Transcription Factor TFIIA Complex DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cerebral Cortex Regionalization Regionalization RNA Polymerase II General Transcription Initiation Factor Binding Central Nervous System Development Nucleoplasm Anterior/posterior Pattern Specification RNA Metabolic Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Neuron Differentiation Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Embryonic Skeletal System Morphogenesis
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