MAGEB6 and APBA2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MAGEB6	APBA2
Name		MAGE family member B6	amyloid beta precursor protein binding family A member 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Plasma Membrane Dendritic Spine Schaffer Collateral - CA1 Synapse Presynapse
	Molecular Function	Protein Binding	Amyloid-beta Binding Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II	In Utero Embryonic Development Chemical Synaptic Transmission Nervous System Development Locomotory Behavior Regulation Of Gene Expression Protein Transport Multicellular Organism Growth Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways		None	Neurexins and neuroligins
GWAS		No GWAS studies recorded	Longevity (100 years and older) ( 33948810 ) Response to mTOR inhibitor (rapamycin) ( 24009623 ) SAPHO syndrome ( 33816493 ) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583 ) Temperament ( 22832960 )
Interacting Genes		7 interacting genes: APBA2 ATXN1 HACL1 HTT PHC2 ROBO1 SUPV3L1	16 interacting genes: APP ARF3 ARF4 CLSTN1 CLSTN3 HUNK LRP1 LRP2 LRP8 MAGEB6 MAPK6 NECAB3 NRXN1 RELA STXBP1 USP20
Entrez ID		158809	321
HPRD ID		06628	04090
Ensembl ID		ENSG00000176746	ENSG00000034053
Uniprot IDs		Q8N7X4	Q59G28 Q99767
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Identical Protein Binding Mitochondrial RNA Surveillance Mitochondrial NcRNA Surveillance Mitochondrial MRNA Surveillance 2-hydroxyacyl-CoA Lyase Activity 2-hydroxyphytanoyl-CoA Lyase Activity Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Aggrephagy Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Lipophagy Learning Positive Regulation Of CAMKK-AMPK Signaling Cascade Negative Regulation Of Negative Chemotaxis Axon Midline Choice Point Recognition Regulation Of Negative Chemotaxis Roundabout Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration POZ Domain Binding Positive Regulation Of Mitochondrial RNA Catabolic Process Mitochondrial Degradosome Mitochondrial MRNA Catabolic Process Methyl-branched Fatty Acid Metabolic Process Phytanic Acid Metabolic Process Locomotory Behavior Vocal Learning LRR Domain Binding Heart Induction Axon Choice Point Recognition Negative Regulation Of Chemokine-mediated Signaling Pathway Poly(G) Binding Mitochondrial RNA 3'-end Processing Mitochondrial RNA Catabolic Process 3'-5' RNA Helicase Activity Fatty Acid Alpha-oxidation Thiamine Pyrophosphate Binding Observational Learning Positive Regulation Of Neurogenesis Regulation Of Heart Morphogenesis Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Carbon-carbon Lyase Activity Brain Development Profilin Binding Protein Targeting To Peroxisome Axon Guidance Receptor Activity Learning Or Memory Endocardial Cushion Formation Positive Regulation Of Nervous System Development Nuclear Inclusion Body	Regulation Of Synapse Organization Positive Regulation Of Synaptic Transmission Vesicle-mediated Transport Positive Regulation Of Nervous System Development Glutamatergic Synapse Low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Establishment Of Protein Localization Calcium Ion Binding Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Cargo Receptor Activity Regulation Of Nervous System Development Protein Transport Modulation Of Chemical Synaptic Transmission Astrocyte Activation Involved In Immune Response Chemical Synaptic Transmission Intracellular Protein Localization Positive Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Developmental Process Golgi Apparatus Trans-synaptic Signaling NMDA Selective Glutamate Receptor Signaling Pathway Synaptic Signaling Regulation Of Synapse Assembly Positive Regulation Of Protein Catabolic Process In The Vacuole Positive Regulation Of Synapse Assembly Receptor Complex Clathrin-coated Pit Endocytosis Retinoid Metabolic Process Regulation Of Lysosomal Protein Catabolic Process Diterpenoid Metabolic Process Positive Regulation Of Multicellular Organismal Process Acetylcholine Receptor Binding Amyloid-beta Binding Terpenoid Metabolic Process Regulation Of Cell Junction Assembly Neuron Projection Morphogenesis Cell Projection Morphogenesis Cellular Response To Growth Factor Stimulus Isoprenoid Metabolic Process Positive Regulation Of Catabolic Process Heparan Sulfate Proteoglycan Binding Astrocyte Activation Positive Regulation Of Cell Junction Assembly Platelet Alpha Granule Transcytosis Regulation Of Amyloid-beta Clearance Cell-cell Signaling