SPINT1 and FAM46A

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SPINT1	FAM46A
Gene Name		serine peptidase inhibitor, Kunitz type 1	family with sequence similarity 46, member A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development	Regulation Of Gene Expression Regulation Of Blood Coagulation
Pathways
Drugs
Diseases
GWAS		Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Breast cancer ( 22976474) Corneal structure ( 23291589) Height ( 20881960 23563607)
Protein-Protein Interactions		4 interactors: FAM46A HGFAC ST14 UBQLN4	16 interactors: ATXN1 BAG6 BCCIP CD93 COL4A2 DYNC1H1 EGLN2 HDLBP HTRA1 KEAP1 NR2F2 PSG3 RNF14 SPINT1 TBX4 ZFYVE9
Entrez ID		6692	55603
HPRD ID		05494	13311
Ensembl ID		ENSG00000166145	ENSG00000112773
Uniprot IDs		O43278	Q96IP4
PDB IDs		1YC0 4ISL 4ISN 4ISO
Enriched GO Terms of Interacting Partners?			Embryo Development Placenta Blood Vessel Development Intracellular Receptor Signaling Pathway Blood Vessel Development Vasculature Development Lung Development Respiratory Tube Development Radial Pattern Formation Respiratory System Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Transcription Involved In Lymphatic Endothelial Cell Fate Commitment Anatomical Structure Development Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cardiovascular System Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cellular Response To Growth Factor Stimulus Transcription, DNA-templated Blood Vessel Morphogenesis Dentinogenesis Proteasomal Ubiquitin-independent Protein Catabolic Process Embryonic Placenta Development Response To Estradiol RNA Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Process Tissue Development In Utero Embryonic Development Neuroendocrine Cell Differentiation Tail-anchored Membrane Protein Insertion Into ER Membrane Epithelium Development
Tagcloud ?			al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel ppp2r4 reannotation reserve scc sprr2d stxbp5 tongue tumorigenic validate
Tagcloud (Difference) ?			al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel ppp2r4 reannotation reserve scc sprr2d stxbp5 tongue tumorigenic validate
Tagcloud (Intersection) ?