SPINT1 and HGFAC

Number of citations of the paper that reports this interaction (PMID 11013244)
12

Data Source:
HPRD (in vivo, in vitro)

		SPINT1	HGFAC
Gene Name		serine peptidase inhibitor, Kunitz type 1	HGF activator
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Serine-type Endopeptidase Activity Serine-type Peptidase Activity
	Biological Process	Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development	Proteolysis
Pathways
Drugs
Diseases
GWAS		Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		4 interactors: FAM46A HGFAC ST14 UBQLN4	5 interactors: F2 HGF KLKB1 SPINT1 SPINT2
Entrez ID		6692	3083
HPRD ID		05494	05184
Ensembl ID		ENSG00000166145	ENSG00000109758
Uniprot IDs		O43278	D6RAR4 Q04756
PDB IDs		1YC0 4ISL 4ISN 4ISO	1YBW 1YC0 2R0K 2R0L 2WUB 2WUC 3K2U
Enriched GO Terms of Interacting Partners?			Regulation Of Protein Processing Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Fibrinolysis Regulation Of Proteolysis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Fibrinolysis Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Peptidase Activity Negative Regulation Of Blood Coagulation Blood Coagulation Hemostasis Negative Regulation Of Coagulation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Wound Healing Acute Inflammatory Response Regulation Of Body Fluid Levels Regulation Of Phosphatidylinositol 3-kinase Signaling Wound Healing Regulation Of Blood Coagulation Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Wounding Negative Regulation Of Cellular Metabolic Process Regulation Of Wound Healing Negative Regulation Of Catalytic Activity Factor XII Activation Protein Activation Cascade Platelet Activation Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Myoblast Proliferation Positive Regulation Of Fibrinolysis Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Plasminogen Activation Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Positive Regulation Of Myelination Plasma Kallikrein-kinin Cascade Branching Involved In Labyrinthine Layer Morphogenesis Negative Regulation Of Fibrinolysis Positive Regulation Of Neuron Projection Regeneration Movement Of Cell Or Subcellular Component Extracellular Matrix Organization
Tagcloud ?			ascertain biovu chance clinician cngb3 compelling convulsions emr f5 gpr98 homozygotes inferred inheritance macular maf mendelian nssnp nssnps omim permuted platforms refine rs13157270 rs16844401 rs3735972 rs6031 synonymous twleve vanderbilt
Tagcloud (Difference) ?			ascertain biovu chance clinician cngb3 compelling convulsions emr f5 gpr98 homozygotes inferred inheritance macular maf mendelian nssnp nssnps omim permuted platforms refine rs13157270 rs16844401 rs3735972 rs6031 synonymous twleve vanderbilt
Tagcloud (Intersection) ?