SPINT1 and ST14

Number of citations of the paper that reports this interaction (PubMedID 10373425)
0

Data Source:
HPRD (in vitro, in vivo)

		SPINT1	ST14
Description		serine peptidase inhibitor, Kunitz type 1	ST14 transmembrane serine protease matriptase
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Membrane Extracellular Exosome	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Neural Tube Closure Embryonic Placenta Development Epidermis Development Extracellular Matrix Organization Positive Regulation Of Glial Cell Differentiation Epithelium Development Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Cellular Response To BMP Stimulus Negative Regulation Of Neural Precursor Cell Proliferation	Neural Tube Closure Proteolysis Protein Catabolic Process Keratinocyte Differentiation Epithelial Cell Differentiation Animal Organ Development Epithelial Cell Morphogenesis Involved In Placental Branching
Pathways		MET Receptor Activation Signaling by MST1	Formation of the cornified envelope Formation of the cornified envelope
Drugs			Urokinase Benzamidine Camostat
Diseases			Ichthyosis with hypotrichosis
GWAS		Blood protein levels ( 30072576) Malaria ( 31844061) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Adverse response to drug ( 30420678) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		23 interacting genes: ADAM33 AGR3 CLDN11 CLEC7A FAM3C HGFAC HMGB1 KRTAP1-3 MAL NLGN3 SLC38A7 SMCO4 ST14 TENT5A TF TMEM109 TMEM190 TMEM97 TSPAN33 UBQLN2 UBQLN4 UPK1B VAMP5	16 interacting genes: AKT1 APC CASP8 CDCP1 CDKN2C CHEK2 F2RL1 HGF PDGFC PHB1 PLAU RAD51 RGS16 SPINT1 STK11 TGFB1
Entrez ID		6692	6768
HPRD ID		05494	06005
Ensembl ID		ENSG00000166145	ENSG00000149418
Uniprot IDs		O43278	Q9Y5Y6
PDB IDs		1YC0 2MSX 4ISL 4ISN 4ISO 5EZD 5H7V	1EAW 1EAX 2GV6 2GV7 3BN9 3NCL 3NPS 3P8F 3P8G 3SO3 4IS5 4ISL 4ISN 4ISO 4JYT 4JZ1 4JZI 4O97 4O9V 4R0I 5LYO 6N4T 6T9T 8G1V 8G1W
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Wound Healing Cell Surface Positive Regulation Of Monocyte Chemotactic Protein-1 Production Basal Part Of Cell	Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Motility Regulation Of Cell Cycle Phase Transition Cell Population Proliferation Regulation Of Cell Cycle Regulation Of Locomotion Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Programmed Cell Death Response To Ionizing Radiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Cell Growth Response To Glycoside Cellular Response To Radiation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of ERK1 And ERK2 Cascade Response To Stress Regulation Of Cell Growth Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Population Proliferation Cellular Response To Ionizing Radiation Positive Regulation Of Protein Localization Response To Radiation Positive Regulation Of Cellular Component Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Innate Immune Response Negative Regulation Of Growth Negative Regulation Of Intracellular Signal Transduction Anoikis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Defense Response Positive Regulation Of MAPK Cascade
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