SPINT1 and ST14

Number of citations of the paper that reports this interaction (PMID 10373425)
43

Data Source:
HPRD (in vivo, in vitro)

		SPINT1	ST14
Gene Name		serine peptidase inhibitor, Kunitz type 1	suppression of tumorigenicity 14 (colon carcinoma)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Extracellular Vesicular Exosome	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Serine-type Endopeptidase Activity Serine-type Peptidase Activity
	Biological Process	Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development	Proteolysis Keratinocyte Differentiation
Pathways
Drugs			Urokinase Benzamidine
Diseases
GWAS		Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		4 interactors: FAM46A HGFAC ST14 UBQLN4	7 interactors: CDCP1 F2RL1 HGF PDGFC PLAU RGS16 SPINT1
Entrez ID		6692	6768
HPRD ID		05494	06005
Ensembl ID		ENSG00000166145	ENSG00000149418
Uniprot IDs		O43278	Q9Y5Y6
PDB IDs		1YC0 4ISL 4ISN 4ISO	1EAW 1EAX 2FMV 2GV6 2GV7 3BN9 3NCL 3NPS 3P8F 3P8G 3SO3 4IS5 4ISL 4ISN 4ISO
Enriched GO Terms of Interacting Partners?			Blood Coagulation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Hemostasis Regulation Of Phosphatidylinositol 3-kinase Signaling Interleukin-10 Secretion Negative Regulation Of Chemokine Secretion Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Regulation Of Blood Coagulation Regulation Of Body Fluid Levels Regulation Of Cell Migration Wound Healing Regulation Of Cell Motility Regulation Of Wound Healing Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Wounding Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Chemokine Secretion Chemokine (C-C Motif) Ligand 2 Secretion Positive Regulation Of Eosinophil Degranulation Positive Regulation Of DNA Metabolic Process Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Cell Migration Positive Regulation Of Phosphorylation Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Renin Secretion Into Blood Stream Myoblast Proliferation Interleukin-1 Beta Secretion Cell Motility Regulation Of Peptidyl-tyrosine Phosphorylation Interleukin-10 Production Regulation Of Catalytic Activity Positive Regulation Of Glomerular Filtration Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Cytokine Secretion Involved In Immune Response Mature Conventional Dendritic Cell Differentiation Interleukin-1 Secretion Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Interleukin-6 Secretion Negative Regulation Of Signal Transduction Negative Regulation Of Endopeptidase Activity Interferon-gamma Secretion Negative Regulation Of Peptidase Activity Activation Of Protein Kinase Activity Positive Regulation Of Cell Projection Organization Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling
Tagcloud ?			acetylation box coding compartment downregulates emt enables epcam epithelial esrp1 expected h358 h3k27 h3k9 h4 hdac hgf immunocytochemistry immunoprecipitation mesenchymal metastasis migratory note protease rab25 serine splicing stroma zeb1
Tagcloud (Difference) ?			acetylation box coding compartment downregulates emt enables epcam epithelial esrp1 expected h358 h3k27 h3k9 h4 hdac hgf immunocytochemistry immunoprecipitation mesenchymal metastasis migratory note protease rab25 serine splicing stroma zeb1
Tagcloud (Intersection) ?