VPS37D and CEP55

Number of citations of the paper that reports this interaction (PubMedID 17853893)
52

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		VPS37D	CEP55
Description		VPS37D subunit of ESCRT-I	centrosomal protein 55
Image		No pdb structure
GO Annotations	Cellular Component	ESCRT I Complex Endosome Endosome Membrane Membrane Late Endosome Membrane Extracellular Exosome	Cytoplasm Centrosome Centriole Cytoskeleton Membrane Midbody Cleavage Furrow Intercellular Bridge Flemming Body
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Protein Targeting To Membrane Protein Targeting To Vacuole Protein Transport Macroautophagy Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission	Mitotic Cytokinesis Nucleus Organization Mitotic Metaphase Chromosome Alignment Establishment Of Protein Localization Cell Division Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Midbody Abscission Cranial Skeletal System Development
Pathways		Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs
Diseases
GWAS		Coffee consumption (cups per day) ( 25288136) Gamma glutamyl transferase levels ( 29403010) Hypertriglyceridemia ( 23505323) Malaria ( 31844061) Serum albumin levels ( 29403010) Serum uric acid levels ( 29403010)	High density lipoprotein cholesterol levels ( 30498476) Metabolite levels ( 23823483)
Interacting Genes		5 interacting genes: ARMC7 CEP55 HGS SNCA TSG101	94 interacting genes: AIRIM AKAP9 ANXA11 ARHGEF15 BAG4 C1orf216 CBY2 CCBE1 CCDC120 CCHCR1 CDC37 CDC45 CDK1 CDSN CEP57L1 CFTR COL8A1 CPSF7 DTNB ECSIT EIF1AD ENKD1 ESS2 EXOSC5 FAM161B FAM90A1 FBF1 FXR2 GOLGA2 GOLGA8DP HAUS1 HGS HNRNPA0 HSF2BP KANK2 KIFC3 KRT31 LENG1 LGALS4 LRRC23 MAPK1 MAPK1IP1L MFAP1 MIA3 MORF4L2 NDEL1 NEDD4L NOS3 NTAQ1 NXF1 OGT PCNT PDCD6IP PEF1 PIN1 PLEKHG6 PLK1 POLM POM121 PPP1R16B PRPF6 PSEN2 PSMC2 PTPN23 PWWP3A RAB3D RBM14 RBM17 RBM22 RBM42 RBPMS RCOR3 RNF32 SDCBP SF1 SFPQ SNRPB SNRPN SNW1 SS18L1 SUPT5H TCL1A TEAD4 TEX11 TFG TFIP11 TP53BP2 TSG101 UBC VPS37C VPS37D WASHC1 WASHC3 ZNF48
Entrez ID		155382	55165
HPRD ID		19106	12569
Ensembl ID		ENSG00000176428	ENSG00000138180
Uniprot IDs		Q86XT2	Q53EZ4
PDB IDs			3E1R 3WUT 3WUU 3WUV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Exocytosis Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Membrane Organization Regulation Of Exocytosis Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Flemming Body Multivesicular Body Organization Multivesicular Body Assembly Late Endosome To Vacuole Transport Positive Regulation Of Secretion By Cell Endosome Transport Via Multivesicular Body Sorting Pathway Positive Regulation Of Secretion Membrane Fission Multivesicular Body Sorting Pathway Establishment Of Protein Localization To Vacuole Regulation Of MAP Kinase Activity Receptor Internalization Organelle Localization Response To Desipramine Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Protein Localization To Vacuole Endosome Organization Regulation Of Vesicle-mediated Transport Regulation Of Phosphorus Metabolic Process Regulation Of Secretion By Cell Ubiquitin Binding Establishment Of Vesicle Localization Regulation Of Secretion Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Vesicle Localization Lysosomal Transport Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Ubiquitin-dependent Endocytosis Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Positive Regulation Of Endocytosis Negative Regulation Of Chaperone-mediated Autophagy Macroautophagy Positive Regulation Of Viral Budding Via Host ESCRT Complex ESCRT-0 Complex	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Protein Binding Spliceosomal Complex Centrosome MRNA Processing Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway RNA Splicing Nucleoplasm MRNA Metabolic Process Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Catalytic Step 2 Spliceosome Cytoskeleton Multivesicular Body Assembly Multivesicular Body Organization Positive Regulation Of Exosomal Secretion Late Endosome To Vacuole Transport Organelle Organization Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Endosome Transport Via Multivesicular Body Sorting Pathway RNA Processing Calcium-dependent Protein Binding RNA Binding Viral Budding Via Host ESCRT Complex Multivesicular Body Sorting Pathway Positive Regulation Of Exocytosis Viral Budding MRNA Binding Protein Localization To Vacuole Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cellular Component Assembly Nucleic Acid Metabolic Process Microtubule Nucleation Cytosol Establishment Of Protein Localization To Vacuole ESCRT I Complex Centriole Cytoplasm Spindle Nucleic Acid Binding U4/U6 X U5 Tri-snRNP Complex Microtubule Cytoskeleton Organization Involved In Mitosis MRNA Cis Splicing, Via Spliceosome SnRNP Binding Endosome Organization Microtubule Organizing Center Organization Membrane Fission Microtubule-based Process Organelle Assembly
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