IDO1 and SLC20A2

		IDO1	SLC20A2
Description		indoleamine 2,3-dioxygenase 1	solute carrier family 20 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Smooth Muscle Contractile Fiber Stereocilium Bundle	Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Exosome
	Molecular Function	Tryptophan 2,3-dioxygenase Activity Electron Transfer Activity Oxidoreductase Activity Heme Binding Indoleamine 2,3-dioxygenase Activity Metal Ion Binding Dioxygenase Activity	Virus Receptor Activity Phosphate Transmembrane Transporter Activity Sodium:phosphate Symporter Activity Symporter Activity Signaling Receptor Activity
	Biological Process	Immune System Process Positive Regulation Of T Cell Tolerance Induction Positive Regulation Of Chronic Inflammatory Response Positive Regulation Of Type 2 Immune Response L-tryptophan Catabolic Process Inflammatory Response Female Pregnancy L-tryptophan Catabolic Process To Kynurenine Quinolinate Biosynthetic Process Response To Lipopolysaccharide Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Multicellular Organismal Response To Stress Kynurenic Acid Biosynthetic Process 'de Novo' NAD+ Biosynthetic Process From L-tryptophan Swimming Behavior T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process	Monoatomic Ion Transport Sodium Ion Transport Phosphate Ion Transport Positive Regulation Of Bone Mineralization Phosphate Ion Transmembrane Transport Sodium Ion Transmembrane Transport Symbiont Entry Into Host Cell
Pathways		Tryptophan catabolism	Sodium-coupled phosphate cotransporters Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)
Drugs		Nitric Oxide Cannabidiol Medical Cannabis Nabiximols
Diseases
GWAS			Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Glycated hemoglobin levels ( 28898252 34059833) Hematocrit ( 32888494) Hemoglobin levels ( 32327693) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 27863252 29403010) Pulse pressure ( 27841878 28135244 30578418) Red blood cell count ( 32888494)
Interacting Genes		5 interacting genes: APP DDX24 FBXL17 PPP1R16A TERF2IP	1 interacting genes: CCR5
Entrez ID		3620	6575
HPRD ID		00935	08865
Ensembl ID		ENSG00000131203	ENSG00000168575
Uniprot IDs		A0A348GSI3 P14902	A0A384MR38 B2RBR4 B4DJ71 Q08357
PDB IDs		2D0T 2D0U 4PK5 4PK6 4U72 4U74 5EK2 5EK3 5EK4 5ETW 5WHR 5WMU 5WMV 5WMW 5WMX 5WN8 5XE1 6AZU 6AZV 6AZW 6CXU 6CXV 6DPQ 6DPR 6E35 6E40 6E41 6E42 6E43 6E44 6E45 6E46 6F0A 6KOF 6KPS 6KW7 6MQ6 6O3I 6PU7 6PZ1 6R63 6UBP 6V52 6WJY 6WPE 6X5Y 7A62 7AH4 7AH5 7AH6 7B1O 7E0O 7E0P 7E0Q 7E0S 7E0T 7E0U 7M63 7M7D 7NGE 7P0N 7P0R 7RRB 7RRC 7RRD 7YXT 7Z2L 7ZV3 8ABX 8FUR 8I7L 8U5I 9ESB 9ESC 9ESE 9ESG
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Leukocyte Apoptotic Process Chemokine (C-C Motif) Ligand 5 Binding Kynurenic Acid Biosynthetic Process Indoleamine 2,3-dioxygenase Activity Swimming Behavior Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Quinolinate Biosynthetic Process Positive Regulation Of Chronic Inflammatory Response Smooth Muscle Contractile Fiber Tryptophan 2,3-dioxygenase Activity Quinolinate Metabolic Process L-tryptophan Catabolic Process To Kynurenine Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Inflammatory Response Negative Regulation Of Macrophage Apoptotic Process Kynurenine Metabolic Process L-tryptophan Catabolic Process Regulation Of Chronic Inflammatory Response 'de Novo' NAD+ Biosynthetic Process From L-tryptophan Positive Regulation Of T Cell Tolerance Induction Stereocilium Bundle Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Positive Regulation Of Tolerance Induction Regulation Of T Cell Tolerance Induction L-tryptophan Metabolic Process Positive Regulation Of T Cell Apoptotic Process Chemokine Receptor Activity Dendritic Cell Migration Dendritic Cell Chemotaxis Response To Cholesterol Response To Lipid Negative Regulation Of Programmed Cell Death C-C Chemokine Binding C-C Chemokine Receptor Activity Negative Regulation Of Apoptotic Process Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Sarcoplasmic Reticulum Calcium Ion Transport Negative Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Interleukin-10 Production Aromatic Amino Acid Family Catabolic Process Negative Regulation Of T Cell Apoptotic Process NAD+ Biosynthetic Process Regulation Of Tolerance Induction Positive Regulation Of Type 2 Immune Response Benzene-containing Compound Metabolic Process Pyridine Nucleotide Biosynthetic Process Positive Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Leukocyte Apoptotic Process Regulation Of Myeloid Cell Apoptotic Process
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