IDO1 and DDX24

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		IDO1	DDX24
Gene Name		indoleamine 2,3-dioxygenase 1	DEAD (Asp-Glu-Ala-Asp) box helicase 24
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Smooth Muscle Contractile Fiber Stereocilium Bundle	Nucleolus Membrane
	Molecular Function	Tryptophan 2,3-dioxygenase Activity Electron Carrier Activity Heme Binding Indoleamine 2,3-dioxygenase Activity Metal Ion Binding	RNA Helicase Activity ATP Binding Poly(A) RNA Binding
	Biological Process	Cytokine Production Involved In Inflammatory Response Positive Regulation Of T Cell Tolerance Induction Positive Regulation Of Chronic Inflammatory Response Positive Regulation Of Type 2 Immune Response Tryptophan Catabolic Process Female Pregnancy Tryptophan Catabolic Process To Kynurenine Response To Lipopolysaccharide Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Multicellular Organismal Response To Stress Kynurenic Acid Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Swimming Behavior Negative Regulation Of T Cell Proliferation Small Molecule Metabolic Process Regulation Of Activated T Cell Proliferation Oxidation-reduction Process Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process	RNA Metabolic Process
Pathways		Tryptophan catabolism Metabolism of amino acids and derivatives
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: APP DDX24 PPP1R16A TERF2IP	31 interactors: BCS1L BRCA1 C9orf9 CSNK2A1 EIF3E EP300 FADD GIT1 GLRA2 HSP90AB1 HSPA5 IDO1 ITGB3BP MKS1 MRPL4 NRXN2 PAFAH1B3 PIN1 POLA2 PRF1 PTPN23 RAE1 SPTAN1 SUMO1 TERF1 TERF2 TERF2IP TMEM9B TPI1 TRDMT1 VDAC3
Entrez ID		3620	57062
HPRD ID		00935	05860
Ensembl ID			ENSG00000089737
Uniprot IDs		P14902	G3V529 Q4V9L5 Q9GZR7
PDB IDs		2D0T 2D0U
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Recombination At Telomere Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Protection From Non-homologous End Joining At Telomere Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Telomere Capping Protein Localization To Chromosome, Telomeric Region Axon Choice Point Recognition Neuron Remodeling Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Double-strand Break Repair Via Homologous Recombination Cellular Copper Ion Homeostasis Regulation Of Telomere Maintenance RNA Metabolic Process RNA-dependent DNA Replication Copper Ion Homeostasis Suckling Behavior Negative Regulation Of DNA Recombination Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Double-strand Break Repair Protein Localization To Chromosome Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Telomere Maintenance Via Telomere Lengthening Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Neuron Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Regulation Of DNA Repair Visual Behavior Neuron Death Heterocycle Metabolic Process	Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Chromosome Organization Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomere Maintenance RNA-dependent DNA Replication Telomeric Loop Formation Age-dependent Telomere Shortening Regulation Of Chromosome Organization Telomere Maintenance Via Telomere Shortening Protection From Non-homologous End Joining At Telomere Regulation Of Organelle Organization Telomere Capping DNA Replication Protein Localization To Chromosome, Telomeric Region Cell Cycle Regulation Of Cell Cycle Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Replicative Cell Aging Response To Stimulus Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Component Organization Cellular Response To Cytokine Stimulus Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Apoptotic Process Mitotic Cell Cycle Process Programmed Cell Death Regulation Of Protein Metabolic Process Response To Cytokine Organelle Organization Cell Cycle Process DNA Metabolic Process Cell Death Death Regulation Of Cytokine-mediated Signaling Pathway Response To External Stimulus Negative Regulation Of DNA Metabolic Process Developmental Process Regulation Of Cell Division Mitotic Cell Cycle Regulation Of Apoptotic Process Regulation Of Signal Transduction
Tagcloud ?		anthracycline assignment bcs carboplatin cb ccl5 cd21 cd80 cd8a ctla4 cxcl13 cxcl9 foxp3 geparsixto hierarchic histopathologic igkc immunogenicity immunologic immunologically infiltrating lpbc ors pmcb standardization taxane tils tn univariable	abrogation box consequent consistently dead degradation elicit helicase interacts mdm2 mediates networks nonproteolytic nucleolar polyubiquitylation pre preribosomal processing promoted proteasomal ribonucleoprotein rrna rrnp stabilization steps triggers ubiquitylation unexpected unexpectedly
Tagcloud (Difference) ?		anthracycline assignment bcs carboplatin cb ccl5 cd21 cd80 cd8a ctla4 cxcl13 cxcl9 foxp3 geparsixto hierarchic histopathologic igkc immunogenicity immunologic immunologically infiltrating lpbc ors pmcb standardization taxane tils tn univariable	abrogation box consequent consistently dead degradation elicit helicase interacts mdm2 mediates networks nonproteolytic nucleolar polyubiquitylation pre preribosomal processing promoted proteasomal ribonucleoprotein rrna rrnp stabilization steps triggers ubiquitylation unexpected unexpectedly
Tagcloud (Intersection) ?