SHISA3 and TMEM147

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SHISA3	TMEM147
Description		shisa family member 3	transmembrane protein 147
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Nuclear Membrane Protein-containing Complex Multi-pass Translocon Complex
	Molecular Function	Protein Binding	Protein Binding Ribosome Binding
	Biological Process	Negative Regulation Of Canonical Wnt Signaling Pathway	Protein Localization To Nuclear Inner Membrane Multi-pass Transmembrane Protein Insertion Into ER Membrane
Pathways
Drugs
Diseases
GWAS		Anthracycline-induced cardiotoxicity in early breast cancer ( 32378780) Impulsivity (attentional) ( 30718321) Type 2 diabetes (age of onset) ( 28060188)	Alanine aminotransferase levels ( 33547301) Liver enzyme levels (alanine transaminase) ( 33972514)
Interacting Genes		7 interacting genes: ANKRD46 CLDN11 CMTM7 MAL MEOX2 PNMA1 TMEM147	61 interacting genes: ABHD16A ABI3 BIK CD40 CD79A CLDN7 CLN8 CLRN1 CREB3L1 CXCR2 CYB5R3 DPM3 EBP EFNA4 ENPP4 ERGIC3 F11R FAM209A FFAR2 FKBP7 GJA8 GLP1R GOLM1 GPR101 GPR37L1 GPR42 GPR61 HTR2C IL3RA KASH5 LDLRAD1 LEUTX LHFPL2 MTIF3 MUC1 PDCD1LG2 PSCA PVR RMDN3 RNF185 SAR1A SCAMP4 SHISA3 SLC10A1 SLC12A7 SLC13A4 SLC18A1 SLC22A1 SLC22A2 SLC35H1 SUSD3 SYNE4 TACR1 TEX29 TMEM14B TMEM237 TMEM248 TMEM252 TMEM42 TMEM52B TSPAN12
Entrez ID		152573	10430
HPRD ID		19108	17633
Ensembl ID		ENSG00000178343	ENSG00000105677
Uniprot IDs		A0PJX4	Q9BVK8
PDB IDs			6W6L 9C7U 9C7V
Enriched GO Terms of Interacting Partners?		Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Protein Insertion Into Membrane Axon Ensheathment B-1a B Cell Differentiation Membrane Raft Polarization Protein Localization To Nuclear Inner Membrane Protein Localization To Paranode Region Of Axon B-1 B Cell Differentiation Peptidase Activator Activity Involved In Apoptotic Process Somite Specification	Membrane Neurotransmitter Reuptake Norepinephrine Uptake Serotonin Uptake Norepinephrine Transport Neurotransmitter Uptake Monoamine Transmembrane Transporter Activity Plasma Membrane G Protein-coupled Receptor Activity Catecholamine Uptake Dopamine Uptake Serotonin Transport Pyrimidine Nucleoside Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Protein Binding Xenobiotic Transmembrane Transporter Activity Dopamine Transport Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Monoamine Transport Xenobiotic Transport Across Blood-brain Barrier Toxin Transmembrane Transporter Activity Polyamine Transmembrane Transport Actin-based Cell Projection Neurotransmitter Transport Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity Xenobiotic Transport Meiotic Nuclear Membrane Microtubule Tethering Complex Transmembrane Transport Amine Transport Organic Cation Transmembrane Transporter Activity Azole Transmembrane Transport Quaternary Ammonium Group Transport Prostaglandin Transport Pyrimidine-containing Compound Transmembrane Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
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