CXADR and AP3B1

		CXADR	AP3B1
Description		CXADR cell adhesion molecule	adaptor related protein complex 3 subunit beta 1
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GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Intercalated Disc Membrane Basolateral Plasma Membrane Apicolateral Plasma Membrane Cell Junction Filopodium Growth Cone Neuromuscular Junction Protein-containing Complex Neuron Projection Cell Body Membrane Raft Anchoring Junction	Mitochondrion Lysosomal Membrane Early Endosome Golgi Apparatus Membrane Membrane Coat AP-3 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Axon Cytoplasm Microvesicle
	Molecular Function	Virus Receptor Activity Signaling Receptor Binding Integrin Binding Protein Binding Beta-catenin Binding PDZ Domain Binding Identical Protein Binding Cell Adhesion Molecule Binding Connexin Binding Cell Adhesive Protein Binding Involved In AV Node Cell-bundle Of His Cell Communication	Protein Binding Protein Phosphatase Binding GTP-dependent Protein Binding
	Biological Process	Mitochondrion Organization Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Heart Development Germ Cell Migration Epithelial Structure Maintenance Actin Cytoskeleton Organization Neutrophil Chemotaxis Homotypic Cell-cell Adhesion Cell-cell Junction Organization Gamma-delta T Cell Activation Symbiont Entry Into Host Cell Defense Response To Virus Cardiac Muscle Cell Development Transepithelial Transport AV Node Cell To Bundle Of His Cell Communication AV Node Cell-bundle Of His Cell Adhesion Involved In Cell Communication Regulation Of AV Node Cell Action Potential	Cell Morphogenesis Toll-like Receptor Signaling Pathway Hematopoietic Progenitor Cell Differentiation Respiratory System Process Protein Targeting Protein Targeting To Lysosome Intracellular Zinc Ion Homeostasis Intracellular Protein Transport Inflammatory Response Lysosome Organization Spermatogenesis Single Fertilization Blood Coagulation Anterograde Axonal Transport Protein Transport Vesicle-mediated Transport Antigen Processing And Presentation Lung Development Granulocyte Differentiation Melanosome Organization Protein Localization To Cell Surface Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Protein Modification Process MRNA Transcription By RNA Polymerase II Pigmentation Positive Regulation Of Transcription By RNA Polymerase II Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Anterograde Synaptic Vesicle Transport Homeostasis Of Number Of Cells Positive Regulation Of NK T Cell Differentiation Platelet Dense Granule Organization Lung Morphogenesis Membrane Organization Establishment Of Protein Localization To Mitochondrial Membrane Involved In Mitochondrial Fission Skin Epidermis Development Melanosome Assembly
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall	Golgi Associated Vesicle Biogenesis Signaling by BRAF and RAF1 fusions
Drugs
Diseases			Hermansky-Pudlak syndrome (HPS)
GWAS		Neutrophil count ( 32888494) Serum alkaline phosphatase levels ( 33547301)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body size at age 10 ( 32376654) Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) FEV1 ( 30804560) Hip circumference adjusted for BMI ( 34021172) Insulin resistance/response ( 21901158) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609 30804560) Metabolite levels ( 23823483) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Triglycerides ( 26780889) Type 2 diabetes ( 31049640)
Interacting Genes		11 interacting genes: ANKRD46 EWSR1 FAM3C JAML LNX1 LNX2 MAL NCOA1 NCOR1 OGT VKORC1	13 interacting genes: AP3S2 ARF1 ARF5 ARF6 ARR3 ATM ATR BUB1 BUB1B CLTC CSNK1A1 GKAP1 SLC30A3
Entrez ID		1525	8546
HPRD ID		11804	04551
Ensembl ID		ENSG00000154639	ENSG00000132842
Uniprot IDs		P78310	A0A0S2Z5J4 A0A8Q3SIM7 O00203
PDB IDs		1EAJ 1F5W 1JEW 1KAC 1P69 1P6A 1RSF 2J12 2J1K 2NPL 2W9L 2WBW 3J6L 3J6M 3J6N 3J6O 7DPZ 7DQ1 7VXZ 7VYK 7VYL 7VYM 7W14	9C58 9C59 9C5A 9C5B 9C5C
Enriched GO Terms of Interacting Partners?		Carbon Catabolite Regulation Of Transcription Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Glycolytic Process Cellular Response To Nutrient Granulocyte Differentiation MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Nuclear Receptor Binding Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Protein Localization To Lysosome Rhythmic Process MRNA Transcription Regulation Of Carbohydrate Catabolic Process Regulation Of Body Fluid Levels Regulation Of ATP Metabolic Process Establishment Of Protein Localization To Mitochondrial Membrane Involved In Mitochondrial Fission Labyrinthine Layer Morphogenesis Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Regulation Of Purine Nucleotide Metabolic Process PDZ Domain Binding Membrane Raft Polarization Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Localization To Vacuole Protein O-acetylglucosaminyltransferase Activity Cellular Response To Thyroglobulin Triiodothyronine Positive Regulation Of Female Receptivity Protein Localization To Paranode Region Of Axon Nuclear Speck Organization Chromatin Organization Positive Regulation Of NK T Cell Differentiation Coagulation Blood Coagulation Hemostasis	Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Histone H2AXS139 Kinase Activity Meiotic Sister Chromatid Cohesion, Centromeric Negative Regulation Of Mitotic Nuclear Division Nucleotide Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Regulation Of Mitotic Sister Chromatid Separation Protein Serine/threonine Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cellular Component Organization Meiotic Sister Chromatid Cohesion Negative Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Separation Regulation Of Cell Cycle Process Negative Regulation Of Chromosome Organization Cell Division Negative Regulation Of Cell Cycle Phase Transition Spindle DNA Strand Resection Involved In Replication Fork Processing Vesicle-mediated Transport Regulation Of Chromosome Organization Replicative Senescence Regulation Of Cellular Response To Heat Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Organelle Organization Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Kinase Activity Negative Regulation Of B Cell Proliferation Negative Regulation Of Cell Cycle Process Positive Regulation Of Chromosome Organization Intracellular Protein Transport Regulation Of Sister Chromatid Segregation Protein Localization To Chromosome Outer Kinetochore Intracellular Protein Localization Regulation Of Mitotic Nuclear Division Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Segregation Kinase Activity Protein Localization To Site Of Double-strand Break Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Component Organization Cellular Response To Gamma Radiation Chromosome Organization
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