IFIH1 and RNF135

Number of citations of the paper that reports this interaction (PubMedID 33373584)
78

Data Source:
BioGRID (enzymatic study)

		IFIH1	RNF135
Description		interferon induced with helicase C domain 1	ring finger protein 135
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Cytoplasm Cytosol Cytoplasmic Stress Granule Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Pattern Recognition Receptor Activity Identical Protein Binding Ribonucleoprotein Complex Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity RIG-I Binding Identical Protein Binding Ribonucleoprotein Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Signal Transduction MRNA Transcription Detection Of Virus Response To Virus Protein Sumoylation Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Type III Interferon Production MDA-5 Signaling Pathway Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Complex Oligomerization Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Cellular Response To Virus Antiviral Innate Immune Response	Protein Polyubiquitination Immune System Process Free Ubiquitin Chain Polymerization Protein Ubiquitination Positive Regulation Of Interferon-beta Production RIG-I Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Protein Homooligomerization Protein K63-linked Ubiquitination Antiviral Innate Immune Response
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses Modulation of host responses by IFN-stimulated genes	DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases		Type I diabetes mellitus
GWAS		Autoimmune thyroid disease ( 32581359) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 33020668) HDL cholesterol levels ( 32203549) Immunoglobulin A ( 20694011) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Psoriasis ( 23143594 25903422 25574825 20953190) Psoriasis vulgaris ( 26626624) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 26502338 28714469 27399966 19838195) Type 1 diabetes ( 17554260 30572963 25751624 21829393 19430480) Vitiligo ( 27723757 22561518) White blood cell count ( 32888494)	Height ( 18391951) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		9 interacting genes: APP CCDC50 KEAP1 RNF10 RNF135 TRIM40 TRIM65 USP3 ZCCHC3	10 interacting genes: CTBP2 ENOX2 GOLGA2 HSF2BP IFIH1 MAVS RIGI TEPSIN UBE2D2 UBE2N
Entrez ID		64135	84282
HPRD ID		09507	11506
Ensembl ID		ENSG00000115267	ENSG00000181481
Uniprot IDs		Q9BYX4	B3KV69 Q8IUD6
PDB IDs		2RQB 3B6E 3GA3 4GL2 7DNI 7DNJ 7JL0 7JL2	7JL1 7JL3 8G7T 8G7U 8G7V
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Innate Immune Response Positive Regulation Of Type I Interferon Production Protein Modification By Small Protein Conjugation Defense Response To Symbiont Defense Response To Other Organism Ubiquitin Protein Ligase Activity Regulation Of Type I Interferon Production Metal Ion Binding Protein Modification Process Positive Regulation Of Cytokine Production Response To Other Organism Positive Regulation Of Interferon-beta Production Immune Response Protein Metabolic Process Protein Ubiquitination Zinc Ion Binding Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Response To Stress Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response Response To External Biotic Stimulus Glycerol-3-phosphate Dehydrogenase (quinone) Activity Protein Polyubiquitination Defense Response To Virus Regulation Of Interferon-beta Production Protein K63-linked Ubiquitination Regulation Of Cytokine Production Regulation Of Defense Response Antiviral Innate Immune Response Acetylcholine Receptor Activator Activity Regulation Of Protein Catabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Glycerol-3-phosphate Shuttle Response To Virus PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Non-canonical NF-kappaB Signal Transduction Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Multicellular Organismal Process Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development	Antiviral Innate Immune Response Cellular Response To Exogenous DsRNA Cellular Response To DsRNA Positive Regulation Of Interferon-alpha Production Response To Exogenous DsRNA Positive Regulation Of Interferon-beta Production Detection Of Virus Response To DsRNA MRNA Transcription Regulation Of Type III Interferon Production Regulation Of Interferon-beta Production Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Positive Regulation Of Response To Cytokine Stimulus Defense Response To Virus Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Dendritic Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Immune Response-activating Signaling Pathway Regulation Of Dendritic Cell Cytokine Production Response To Virus Regulation Of Type I Interferon Production Immune Response-regulating Signaling Pathway Activation Of Immune Response DNA-templated Transcription Regulation Of Interleukin-6 Production Pattern Recognition Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor Production Innate Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Ubiquitin Conjugating Enzyme Activity Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Activation Of Innate Immune Response Pattern Recognition Receptor Activity Intracellular Receptor Signaling Pathway Regulation Of Defense Response To Virus By Host Single-stranded RNA Binding Innate Immune Response Negative Regulation Of Viral Genome Replication Positive Regulation Of Immune Response Type I Interferon-mediated Signaling Pathway Positive Regulation Of Interleukin-8 Production Positive Regulation Of IP-10 Production Coated Vesicle Membrane Defense Response To Symbiont Positive Regulation Of Innate Immune Response Regulation Of Defense Response To Virus Defense Response To Other Organism
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