IFIH1 and USP3

Number of citations of the paper that reports this interaction (PMID 24366338)
1

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		IFIH1	USP3
Gene Name		interferon induced with helicase C domain 1	ubiquitin specific peptidase 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol	Nuclear Chromatin
	Molecular Function	DNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Ribonucleoprotein Complex Binding	Core Promoter Sequence-specific DNA Binding Chromatin Binding Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Zinc Ion Binding Histone Binding
	Biological Process	Detection Of Virus Response To Virus Viral Process Protein Sumoylation Negative Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of Type III Interferon Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus Regulation Of Apoptotic Process Innate Immune Response	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle DNA Repair Regulation Of Transcription, DNA-templated Histone Deubiquitination Regulation Of Protein Stability Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process
Pathways		TRAF3-dependent IRF activation pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Innate Immune System
Drugs
Diseases
GWAS		Immunoglobulin A ( 20694011) Inflammatory bowel disease ( 23128233) Psoriasis ( 20953190) Type 1 diabetes ( 19430480 17554260) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 22561518)	Heart failure ( 20445134)
Protein-Protein Interactions		2 interactors: APP USP3	3 interactors: DDX58 IFIH1 UBC
Entrez ID		64135	9960
HPRD ID		09507	05290
Ensembl ID		ENSG00000115267
Uniprot IDs		Q9BYX4	Q9Y6I4
PDB IDs		2RQB 3B6E 3GA3 4GL2
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Posttranscriptional Regulation Of Gene Expression Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Regulation Of Proteolysis Cellular Copper Ion Homeostasis Histone Deubiquitination Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Neuron Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron Death Platelet Degranulation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Process Controlling Balance Synapse Assembly MRNA 3'-end Processing Regulation Of ERBB Signaling Pathway Regulation Of Cellular Protein Metabolic Process Associative Learning Developmental Cell Growth Regulation Of Synapse Structure Or Activity Negative Regulation Of Cellular Metabolic Process Feeding Behavior Regulation Of Multicellular Organism Growth	Negative Regulation Of Type I Interferon Production Regulation Of Type III Interferon Production Detection Of Virus Positive Regulation Of Type I Interferon Production Regulation Of Type I Interferon Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Intracellular Receptor Signaling Pathway Negative Regulation Of Cytokine Production Regulation Of Innate Immune Response Cellular Response To Virus Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Cytokine Production Immune Response-regulating Signaling Pathway Regulation Of Interferon-beta Production Regulation Of Cytokine Production Viral Process Positive Regulation Of Immune Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Defense Response To Virus Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity RIG-I Signaling Pathway Response To Virus Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune System Process Viral Protein Processing Protein Modification By Small Protein Conjugation Positive Regulation Of Defense Response To Virus By Host Response To Other Organism Notch Receptor Processing Virion Assembly Response To Biotic Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Stress Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein Sumoylation Glycogen Biosynthetic Process Intracellular Transport Of Virus Regulation Of Defense Response To Virus By Host Positive Regulation Of Transcription Factor Import Into Nucleus
Tagcloud ?		adar1 beginning context corticospinal developmentally dysmyelination exome families genotypes helpful hereditary intellect interferon interferons interpreting isgs neuroimaging neurotoxin nonspecific nonsyndromic paraplegia reached rnaseh2b robust signature spastic undetermined unexplained upregulation
Tagcloud (Difference) ?		adar1 beginning context corticospinal developmentally dysmyelination exome families genotypes helpful hereditary intellect interferon interferons interpreting isgs neuroimaging neurotoxin nonspecific nonsyndromic paraplegia reached rnaseh2b robust signature spastic undetermined unexplained upregulation
Tagcloud (Intersection) ?