PPP4R2 and PPP4C

Number of citations of the paper that reports this interaction (PubMedID 18715871)
51

Data Source:
HPRD (in vivo, in vitro)

		PPP4R2	PPP4C
Description		protein phosphatase 4 regulatory subunit 2	protein phosphatase 4 catalytic subunit
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton Protein Phosphatase 4 Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Protein Phosphatase 4 Complex
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Protein-macromolecule Adaptor Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	MRNA Processing RNA Splicing Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Modification Process Regulation Of Double-strand Break Repair	Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways		Processing of DNA double-strand break ends	Processing of DNA double-strand break ends
Drugs
Diseases
GWAS		Mitochondrial DNA copy number (white blood cells) ( 30704525) Pulse pressure ( 30224653 30578418) Refractive error ( 32231278)	Adventurousness ( 30643258) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Eosinophil percentage of white cells ( 32888494) Mean corpuscular volume ( 29403010) Medication use (diuretics) ( 31015401) Schizophrenia ( 25056061 29483656)
Interacting Genes		3 interacting genes: CDK1 CEBPA PPP4C	21 interacting genes: CCDC6 DHX38 GPANK1 HDAC3 IGBP1 JUN NFKB1 PPP2R1A PPP2R5D PPP4R1 PPP4R2 PPP4R3B PPP4R4 REL RELA TIPRL TK1 TMSB4X TP53 TRAF6 UBE2D3
Entrez ID		151987	5531
HPRD ID		11453	03615
Ensembl ID		ENSG00000163605	ENSG00000149923
Uniprot IDs		C9IZF4 Q9NY27	A0A024R625 P60510
PDB IDs
Enriched GO Terms of Interacting Partners?		Thymidine Metabolic Process Pronuclear Fusion Cellular Response To Stress Response To Metal Ion Mitotic DNA-templated DNA Replication Golgi Disassembly Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Regulation Of Schwann Cell Differentiation Negative Regulation Of Cell Cycle Cyclin B1-CDK1 Complex Nuclear DNA Replication Cyclin A1-CDK1 Complex Thymidine Biosynthetic Process Cyclin A2-CDK1 Complex Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Cyclin-dependent Protein Kinase Activity Histone Kinase Activity CHOP-C/EBP Complex Response To Phenylpropanoid RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Protein Phosphatase 4 Complex Fat Cell Proliferation Positive Regulation Of Mitotic Sister Chromatid Segregation Nucleic Acid Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Ventricular Cardiac Muscle Cell Development Mitotic Nuclear Membrane Disassembly Cilium Disassembly Urea Cycle STAT Family Protein Binding Regulation Of DNA Metabolic Process Pyrimidine Nucleoside Metabolic Process Regulation Of Metaphase Plate Congression DNA Strand Resection Involved In Replication Fork Processing Protein Localization To Kinetochore Chromatin Binding Urea Metabolic Process HMG Box Domain Binding Nitrogen Cycle Metabolic Process DNA Repair Membrane Disassembly Nuclear Membrane Disassembly Transcription By RNA Polymerase I	Protein Phosphatase Regulator Activity Tumor Necrosis Factor-mediated Signaling Pathway Protein Phosphatase 4 Complex Non-canonical NF-kappaB Signal Transduction General Transcription Initiation Factor Binding Canonical NF-kappaB Signal Transduction Positive Regulation Of MiRNA Metabolic Process NF-kappaB P50/p65 Complex Protein Phosphatase Activator Activity Chromatin Response To Muscle Stretch Regulation Of MiRNA Metabolic Process Enzyme Binding NF-kappaB Complex DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Binding Transcription Coactivator Binding Cellular Response To Nicotine Positive Regulation Of MiRNA Transcription Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Transcription Repressor Complex Regulation Of Interleukin-12 Production Meiotic Sister Chromatid Cohesion Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Mechanical Stimulus Positive Regulation Of DNA-templated Transcription Initiation Regulation Of MiRNA Transcription Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Response To Interleukin-1 Regulation Of DNA-templated Transcription Initiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Metabolic Process Actinin Binding Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Cellular Response To Angiotensin Cellular Response To Interleukin-6 Protein Phosphatase Type 2A Complex Cytosol Transcription Regulator Complex Cytoplasm Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Chromatin Binding Transcription Cis-regulatory Region Binding
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