GDF7 and BMP7

Number of citations of the paper that reports this interaction (PMID 12741987)
49

Data Source:
HPRD (in vitro)

		GDF7	BMP7
Gene Name		growth differentiation factor 7	bone morphogenetic protein 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Extracellular Region Extracellular Space Extracellular Matrix Membrane-bounded Vesicle
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Protein Homodimerization Activity	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Heparin Binding BMP Receptor Binding
	Biological Process	Axon Guidance Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Roof Plate Formation Spinal Cord Association Neuron Differentiation Gland Morphogenesis BMP Signaling Pathway Epithelial Cell Differentiation Midbrain Development Activin Receptor Signaling Pathway Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Cell Fate Commitment Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Cell Development Reproductive Structure Development Branching Morphogenesis Of An Epithelial Tube Forebrain Morphogenesis Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Morphogenesis Of An Epithelial Fold Positive Regulation Of Tendon Cell Differentiation	Skeletal System Development Ossification Metanephros Development Ureteric Bud Development Mesoderm Formation Mesonephros Development Epithelial To Mesenchymal Transition Axon Guidance Embryonic Pattern Specification Negative Regulation Of Striated Muscle Cell Apoptotic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Dendrite Development Extracellular Matrix Organization Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization BMP Signaling Pathway Epithelial Cell Differentiation Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Estradiol Response To Vitamin D Positive Regulation Of Heterotypic Cell-cell Adhesion Protein Localization To Nucleus Growth Negative Regulation Of Phosphorylation Negative Regulation Of NF-kappaB Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Negative Regulation Of MAP Kinase Activity Response To Peptide Hormone Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Camera-type Eye Morphogenesis Branching Morphogenesis Of An Epithelial Tube Mesenchymal Cell Differentiation Neuron Projection Morphogenesis Cartilage Development Embryonic Skeletal Joint Morphogenesis Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Branching Involved In Salivary Gland Morphogenesis Mesenchyme Development Negative Regulation Of Cell Death Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Monocyte Aggregation Cellular Response To Hypoxia Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Negative Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Mesenchyme Morphogenesis Nephrogenic Mesenchyme Morphogenesis Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Positive Regulation Of Dendrite Development Positive Regulation Of Hyaluranon Cable Assembly Regulation Of Removal Of Superoxide Radicals
Pathways			Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS		Response to statin therapy ( 20339536)	Response to citalopram treatment ( 19846067) White blood cell types ( 21738478)
Protein-Protein Interactions		1 interactors: BMP7	21 interactors: ACTN4 ACVR1 ACVR2A ACVR2B BMPR1A BMPR1B BMPR2 CHRDL2 ENG GDF7 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP5-9 MTUS2 NCOA3 NOG NOTCH2NL SOSTDC1 TRIM27
Entrez ID		151449	655
HPRD ID		06873	00212
Ensembl ID			ENSG00000101144
Uniprot IDs		Q75RY1 Q7Z4P5	A8K571 P18075
PDB IDs			1BMP 1LX5 1LXI 1M4U
Enriched GO Terms of Interacting Partners?		Monocyte Aggregation Negative Regulation Of Glomerulus Development Positive Regulation Of Hyaluranon Cable Assembly Negative Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Negative Regulation Of Cell Proliferation Involved In Kidney Development Nephrogenic Mesenchyme Morphogenesis Regulation Of Glomerular Mesangial Cell Proliferation Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Positive Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Cell Proliferation Involved In Metanephros Development Regulation Of Prostatic Bud Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Regulation Of Removal Of Superoxide Radicals Cell Proliferation Involved In Kidney Development Negative Regulation Of Striated Muscle Cell Apoptotic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Mesenchymal Cell Proliferation Metanephric Mesenchyme Development Negative Regulation Of NF-kappaB Import Into Nucleus Embryonic Skeletal Joint Morphogenesis Embryonic Skeletal Joint Development Regulation Of Stem Cell Maintenance Negative Regulation Of Embryonic Development Regulation Of Response To Reactive Oxygen Species Response To Vitamin D Branching Involved In Salivary Gland Morphogenesis Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Muscle Cell Apoptotic Process Embryonic Camera-type Eye Morphogenesis Positive Regulation Of Bone Mineralization Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Salivary Gland Morphogenesis Embryonic Eye Morphogenesis Salivary Gland Development Negative Regulation Of Mitotic Nuclear Division Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Organ Formation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Muscle Cell Apoptotic Process SMAD Protein Signal Transduction	BMP Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Tissue Development Regulation Of Osteoblast Differentiation Pattern Specification Process Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Activin Receptor Signaling Pathway Regulation Of BMP Signaling Pathway Regulation Of Ossification Positive Regulation Of Ossification Embryonic Morphogenesis Organ Morphogenesis Tube Development Epithelium Development Mesoderm Development Skeletal System Development Enzyme Linked Receptor Protein Signaling Pathway Gastrulation Regulation Of Transcription From RNA Polymerase II Promoter Tissue Morphogenesis Tube Morphogenesis Regulation Of Protein Phosphorylation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Differentiation Embryo Development Signal Transduction By Phosphorylation Organ Development Regulation Of Signaling Positive Regulation Of Cell Differentiation Anatomical Structure Morphogenesis Regulation Of Phosphorylation Protein Phosphorylation Signal Transduction Developmental Process Regulation Of Phosphorus Metabolic Process Epithelial Tube Morphogenesis Signaling Cartilage Development Venous Blood Vessel Development Cell Communication Endothelial Cell Differentiation Developmental Process Involved In Reproduction Positive Regulation Of Protein Phosphorylation Multicellular Organismal Development
Tagcloud ?			antisecretory belonging cd133 celebrex concomittant downregulated esomeprasol favourably feed heterodimer imply indomethacin list master microarrays micrornas niche nsaid nsaids oct4 oncomirs peroperative preservation prominin1 served sox2 stemness suppressors switchoff
Tagcloud (Difference) ?			antisecretory belonging cd133 celebrex concomittant downregulated esomeprasol favourably feed heterodimer imply indomethacin list master microarrays micrornas niche nsaid nsaids oct4 oncomirs peroperative preservation prominin1 served sox2 stemness suppressors switchoff
Tagcloud (Intersection) ?