KRT16 and EPM2AIP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT16	EPM2AIP1
Description		keratin 16	EPM2A interacting protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome	Nucleus Cytoplasm Endoplasmic Reticulum Cytoplasmic Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis	Protein Binding Identical Protein Binding
	Biological Process	Morphogenesis Of An Epithelium Inflammatory Response Cytoskeleton Organization Keratinocyte Differentiation Negative Regulation Of Cell Migration Keratinization Hair Cycle Innate Immune Response Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Keratinocyte Migration Establishment Of Skin Barrier	Glycogen Biosynthetic Process Response To Insulin Positive Regulation Of Glycogen Biosynthetic Process
Pathways		Keratinization Formation of the cornified envelope
Drugs		Zinc Zinc acetate
Diseases		Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex Non-epidermolytic palmoplantar keratoderma (NEPPK)
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Subjective response to lithium treatment ( 26503763) Triglyceride levels ( 32203549)
Interacting Genes		53 interacting genes: AIRIM AMOT ARFIP2 C1orf216 CARD9 CCDC146 CCDC17 CCHCR1 CCNC CDK18 CYTH4 DRC4 EPM2AIP1 GNG10 HGS KIFC3 KLC4 KRT1 KRT6C KRT71 KRT72 KRT73 KRT74 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 LMO1 LNX1 MBD3 PKN1 POLL PPP1R18 PRKAA2 PRPH PUS10 SEMA4C SGF29 SMARCD1 SMARCE1 SNAPIN TCHP TSG101 TTC23 TXLNB USHBP1	47 interacting genes: ACTN1 APPL2 ARHGEF5 C1orf50 CBFA2T3 CCNB1IP1 CNTROB CPSF7 DTX3 EMP2 EPM2A FHL3 GFAP HSF2BP KCTD1 KCTD9 KRT16 KRT75 LDB2 LIN52 LNX1 MAD2L1 MEOX2 MX1 NOC4L OTUD7B PICK1 PRTFDC1 PSMA7 RBMY1F RBMY1J REL SERPINF1 SWSAP1 TFIP11 TNFAIP1 TNKS TRA2B TRIM50 TRIM54 USP54 VPS52 WEE2-AS1 ZBTB14 ZIM2 ZNF620 ZSCAN18
Entrez ID		3868	9852
HPRD ID		01018	07445
Ensembl ID		ENSG00000186832	ENSG00000178567
Uniprot IDs		P08779	Q7L775
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Organization Keratin Filament Structural Constituent Of Skin Epidermis Keratinization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Organization Organelle Organization Protein Binding Cytosol	Identical Protein Binding Positive Regulation Of MRNA Splicing, Via Spliceosome
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