IGF1 and IGFALS

Number of citations of the paper that reports this interaction (PMID 10823924)
18

Data Source:
HPRD (in vivo)

		IGF1	IGFALS
Gene Name		insulin-like growth factor 1 (somatomedin C)	insulin-like growth factor binding protein, acid labile subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Insulin-like Growth Factor Binding Protein Complex Platelet Alpha Granule Lumen	Extracellular Region Extracellular Space Nucleoplasm Extracellular Vesicular Exosome
	Molecular Function	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity	Insulin-like Growth Factor Binding
	Biological Process	Skeletal System Development Cell Activation Blood Vessel Remodeling Platelet Degranulation DNA Replication Movement Of Cell Or Subcellular Component Signal Transduction Ras Protein Signal Transduction Muscle Organ Development Blood Coagulation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Heat Glycolate Metabolic Process Glial Cell Differentiation Regulation Of Gene Expression Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Muscle Hypertrophy Myotube Cell Development Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Water Homeostasis Proteoglycan Biosynthetic Process Platelet Activation Mammary Gland Development Exocrine Pancreas Development Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Protein Import Into Nucleus, Translocation Negative Regulation Of Smooth Muscle Cell Apoptotic Process Multicellular Organism Growth Bone Mineralization Involved In Bone Maturation Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Myoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of DNA Replication Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Glucose Import Positive Regulation Of Ras Protein Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Positive Regulation Of Smooth Muscle Cell Proliferation Branching Morphogenesis Of An Epithelial Tube Inner Ear Development Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Myoblast Proliferation Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Oocyte Development Lung Vasculature Development Lung Lobe Morphogenesis Type I Pneumocyte Differentiation Type II Pneumocyte Differentiation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Prostate Gland Growth Prostate Gland Stromal Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Myoblast Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Cell Adhesion Signal Transduction Cellular Protein Metabolic Process
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Synthesis, secretion, and deacylation of Ghrelin SHC-related events triggered by IGF1R Platelet degranulation IGF1R signaling cascade IRS-related events triggered by IGF1R Peptide hormone metabolism Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Response to elevated platelet cytosolic Ca2+ Platelet activation, signaling and aggregation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Fasting glucose-related traits ( 20081858) Fasting insulin-related traits ( 20081858) Fasting insulin-related traits (interaction with BMI) ( 22581228) Height ( 19893584 20189936) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Insulin-like growth factors ( 21216879)
Protein-Protein Interactions		16 interactors: CTSB E2F1 IDE IGF1R IGFALS IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 IGSF1 NOV TF WISP2	4 interactors: IGF1 IGFBP3 IGFBP5 PDCD6
Entrez ID		3479	3483
HPRD ID		00936	03290
Ensembl ID		ENSG00000017427	ENSG00000099769
Uniprot IDs		P05019 Q13429 Q59GC5 Q5U743	P35858 Q8TAY0
PDB IDs		1B9G 1BQT 1GF1 1GZR 1GZY 1GZZ 1H02 1H59 1IMX 1PMX 1TGR 1WQJ 2DSP 2DSQ 2DSR 2GF1 3GF1 3LRI
Enriched GO Terms of Interacting Partners?		Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Growth Regulation Of Growth Regulation Of Cellular Component Organization Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Signal Transduction Cellular Response To Stimulus Response To Stimulus Cellular Response To Hormone Stimulus Signaling Cell Communication Regulation Of Smooth Muscle Cell Migration Cellular Response To Organic Substance Response To Hormone Regulation Of Cell Proliferation Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Response To Organic Substance Cellular Protein Metabolic Process Developmental Process Insulin Receptor Signaling Pathway Regulation Of Carbohydrate Metabolic Process Gland Morphogenesis Regulation Of Signal Transduction Cellular Response To Organonitrogen Compound Regulation Of Cellular Process Regulation Of Cell Death Cellular Response To Insulin Stimulus Regulation Of Signaling Negative Regulation Of Smooth Muscle Cell Proliferation Female Pregnancy Regulation Of Cell Migration Regulation Of Cell Motility Exocrine System Development Ubiquitin Homeostasis Inactivation Of MAPKK Activity Insulin Catabolic Process Protein Metabolic Process Negative Regulation Of Cell Proliferation Regulation Of Locomotion Response To Insulin Regulation Of Cellular Component Movement Regulation Of Steroid Biosynthetic Process Positive Regulation Of Signal Transduction Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Kinase B Signaling Cellular Response To Peptide Reproductive Process Positive Regulation Of Intracellular Signal Transduction	Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Migration Regulation Of Smooth Muscle Cell Proliferation Regulation Of Glucose Metabolic Process Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Protein Kinase B Signaling Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Carbohydrate Metabolic Process Type B Pancreatic Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Ossification Regulation Of Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase B Signaling Regulation Of Growth Regulation Of Protein Metabolic Process Negative Regulation Of Cell Proliferation Cell Proliferation Response To Heat Tissue Remodeling Positive Regulation Of Intracellular Signal Transduction Regulation Of Osteoblast Differentiation Regulation Of Signal Transduction Osteoblast Differentiation Positive Regulation Of Epithelial Cell Proliferation Apoptotic Process Gland Morphogenesis Regulation Of Signaling Programmed Cell Death Mammary Gland Development Cell Death Death Response To Temperature Stimulus Negative Regulation Of Cell Migration Regulation Of Ossification Prostate Gland Stromal Morphogenesis Glycolate Metabolic Process Skeletal Muscle Tissue Growth Negative Regulation Of Cell Motility Negative Regulation Of Cellular Component Movement Striated Muscle Cell Differentiation Positive Regulation Of Signal Transduction Negative Regulation Of Oocyte Development
Tagcloud ?		alphair3 augmenting blastocyst blastocysts cytoplasm embryo embryos entirely fallopian immunocytochemistry immunoreactive implantation inner intense ivf lining maternal maternally midcycle mimicking paracrine preimplantation reproductive supplementation transcripts tubal tube uterus	112g 11p15 1291delt 45m 6psi ccdc8 cul7 encompasses genetics ghi ghr height homozygous hypomethylation igf1 imprinting insensitive insensitivity ivs5ds justifying mupd7 obsl1 pseudoexon russell sds srs stat5b stature suspected
Tagcloud (Difference) ?		alphair3 augmenting blastocyst blastocysts cytoplasm embryo embryos entirely fallopian immunocytochemistry immunoreactive implantation inner intense ivf lining maternal maternally midcycle mimicking paracrine preimplantation reproductive supplementation transcripts tubal tube uterus	112g 11p15 1291delt 45m 6psi ccdc8 cul7 encompasses genetics ghi ghr height homozygous hypomethylation imprinting insensitive insensitivity ivs5ds justifying mupd7 obsl1 pseudoexon russell sds srs stat5b stature suspected
Tagcloud (Intersection) ?		igf1